Chronic non-healing wounds represent a major source of morbidity for patients and a significant economic burden. Current wound care treatments are generally passive and are unable to adapt to changes in the wound environment in real time. By integrating multimodal sensors and adding stimulators in a bandage, real-time physiological monitoring is possible and provides an opportunity for active intervention into the complex wound environment. Here, we develop a battery-free flexible bioelectronic system consisting of wirelessly powered, closed-loop sensing and stimulation circuits with tissue-interfacing tough conducting hydrogel electrodes for robust signal transduction, on-demand adhesion, and detachment. Using multiple pre-clinical models, we demonstrate the capability of our wound care system to continuously monitor skin impedance and temperature, to trigger directional electrical stimulation. The accelerated wound closure was confirmed to be due to the activation of pro-regenerative genes linked to accelerated wound closure, increased neovascularization, and enhanced dermal recovery.

中文翻译：

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用于慢性伤口管理和加速组织再生的无线闭环智能绷带

慢性不愈合伤口是患者发病率和经济负担的主要来源。目前的伤口护理治疗通常是被动的，无法实时适应伤口环境的变化。通过集成多模式传感器并在绷带中添加刺激器，实时生理监测成为可能，并为主动干预复杂的伤口环境提供了机会。在这里，我们开发了一种无电池的柔性生物电子系统，该系统由无线供电的闭环传感和刺激电路组成，具有组织接口的坚韧导电水凝胶电极，用于强大的信号转导、按需粘附和分离。使用多个临床前模型，我们展示了我们的伤口护理系统能够持续监测皮肤阻抗和温度，从而触发定向电刺激。加速伤口闭合被证实是由于促再生基因的激活，这些基因与加速伤口闭合、增加的新血管形成和增强的皮肤恢复有关。