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Environmentally Adaptive Shape-Morphing Microrobots for Localized Cancer Cell Treatment
ACS Nano ( IF 15.8 ) Pub Date : 2021-10-19 , DOI: 10.1021/acsnano.1c06651 Chen Xin 1 , Dongdong Jin 2 , Yanlei Hu 1 , Liang Yang 3 , Rui Li 1 , Li Wang 4 , Zhongguo Ren 1 , Dawei Wang 1 , Shengyun Ji 1 , Kai Hu 1 , Deng Pan 1 , Hao Wu 1 , Wulin Zhu 1 , Zuojun Shen 4 , Yucai Wang 4 , Jiawen Li 1 , Li Zhang 2 , Dong Wu 1 , Jiaru Chu 1
ACS Nano ( IF 15.8 ) Pub Date : 2021-10-19 , DOI: 10.1021/acsnano.1c06651 Chen Xin 1 , Dongdong Jin 2 , Yanlei Hu 1 , Liang Yang 3 , Rui Li 1 , Li Wang 4 , Zhongguo Ren 1 , Dawei Wang 1 , Shengyun Ji 1 , Kai Hu 1 , Deng Pan 1 , Hao Wu 1 , Wulin Zhu 1 , Zuojun Shen 4 , Yucai Wang 4 , Jiawen Li 1 , Li Zhang 2 , Dong Wu 1 , Jiaru Chu 1
Affiliation
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Microrobots have attracted considerable attention due to their extensive applications in microobject manipulation and targeted drug delivery. To realize more complex micro-/nanocargo manipulation (e.g., encapsulation and release) in biological applications, it is highly desirable to endow microrobots with a shape-morphing adaptation to dynamic environments. Here, environmentally adaptive shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rates in a pH-responsive hydrogel. Due to a combination with magnetic propulsion, a shape-morphing microcrab (SMMC) is able to perform targeted microparticle delivery, including gripping, transporting, and releasing by “opening–closing” of a claw. As a proof-of-concept demonstration, a shape-morphing microfish (SMMF) is designed to encapsulate a drug (doxorubicin (DOX)) by closing its mouth in phosphate-buffered saline (PBS, pH ∼ 7.4) and release the drug by opening its mouth in a slightly acidic solution (pH < 7). Furthermore, localized HeLa cell treatment in an artificial vascular network is realized by “opening–closing” of the SMMF mouth. With the continuous optimization of size, motion control, and imaging technology, these magnetic SMMRs will provide ideal platforms for complex microcargo operations and on-demand drug release.
中文翻译：
用于局部癌细胞治疗的环境自适应变形微型机器人
微型机器人因其在微物体操作和靶向药物输送中的广泛应用而引起了广泛关注。实现更复杂的微/纳米货物操作（例如., 封装和释放）在生物应用中，非常需要赋予微型机器人形状变形适应动态环境的能力。在这里，通过在 pH 响应水凝胶中以编程方式编码不同的膨胀率，开发了环境自适应形状变形微型机器人 (SMMR)。由于与磁力推进相结合，变形微型蟹 (SMMC) 能够执行有针对性的微粒输送，包括通过爪的“开合”进行抓取、运输和释放。作为概念验证演示，形状变形微型鱼 (SMMF) 旨在通过在磷酸盐缓冲盐水 (PBS，pH ∼ 7.4) 中闭上嘴来封装药物（多柔比星 (DOX)），并通过以下方式释放药物在微酸性溶液 (pH < 7) 中张开嘴。此外，通过SMMF口的“开合”实现人工血管网络中的局部HeLa细胞治疗。随着尺寸、运动控制和成像技术的不断优化，这些磁性 SMMR 将为复杂的微型货物操作和按需药物释放提供理想的平台。
更新日期：2021-11-23
中文翻译：
用于局部癌细胞治疗的环境自适应变形微型机器人
微型机器人因其在微物体操作和靶向药物输送中的广泛应用而引起了广泛关注。实现更复杂的微/纳米货物操作（例如., 封装和释放）在生物应用中，非常需要赋予微型机器人形状变形适应动态环境的能力。在这里，通过在 pH 响应水凝胶中以编程方式编码不同的膨胀率，开发了环境自适应形状变形微型机器人 (SMMR)。由于与磁力推进相结合，变形微型蟹 (SMMC) 能够执行有针对性的微粒输送，包括通过爪的“开合”进行抓取、运输和释放。作为概念验证演示，形状变形微型鱼 (SMMF) 旨在通过在磷酸盐缓冲盐水 (PBS，pH ∼ 7.4) 中闭上嘴来封装药物（多柔比星 (DOX)），并通过以下方式释放药物在微酸性溶液 (pH < 7) 中张开嘴。此外，通过SMMF口的“开合”实现人工血管网络中的局部HeLa细胞治疗。随着尺寸、运动控制和成像技术的不断优化，这些磁性 SMMR 将为复杂的微型货物操作和按需药物释放提供理想的平台。
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