Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. The key advantage of nano spray drying is the production of drug-loaded nanosized particles for various drug delivery applications. The recent developments in nano spray dryer technology and the market launch of the Nano Spray Dryer B-90 by Büchi Labortechnik AG in 2009 enabled the production of submicron spray-dried particles. This review focuses on nanosized drug delivery systems intended for oral administration produced by nano spray drying. First, the nano spray drying concept, the basic technologies implemented in the equipment, and the effects of the various process parameters on the final dry submicron powder properties are presented. Then, the topics of new formulation strategies of oral drugs are highlighted with examples that have entered the research literature in recent years. Next, the subjects of direct conversion of poorly water-soluble drugs, encapsulation of drugs, and drying of preformed nanoparticles are considered. Finally, topics such as morphology, particle size, size distribution, surface analysis, bioavailability, drug release, release kinetics, and solid-state characterization (by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, nuclear magnetic resonance) of oral drug delivery systems produced by nano spray drying are discussed. The review attempts to provide a comprehensive knowledge base with current literature and foresight to researchers working in the field of pharmaceutical technology and nanotechnology and especially in the field of nano spray drying.

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用于口服给药的纳米喷雾干燥药物：综述

喷雾干燥是一项快速、简单、可重复和可扩展的重要技术。它的应用范围很广，即在食品、化工、药品的封装中。该技术可分为常规喷雾干燥和纳米喷雾干燥。纳米喷雾干燥的主要优势是生产用于各种药物递送应用的载药纳米颗粒。纳米喷雾干燥器技术的最新发展以及 Büchi Labortechnik AG 于 2009 年向市场推出的纳米喷雾干燥器 B-90 使得亚微米喷雾干燥颗粒的生产成为可能。本综述重点关注通过纳米喷雾干燥生产的用于口服给药的纳米级药物递送系统。一、纳米喷雾干燥概念，设备中实施的基本技术，并介绍了各种工艺参数对最终干燥亚微米粉末性能的影响。然后，通过近年来进入研究文献的实例突出了口服药物新制剂策略的主题。接下来，考虑水溶性差的药物的直接转化、药物的封装和预制纳米颗粒的干燥等主题。最后，诸如形态、粒度、粒度分布、表面分析、生物利用度、药物释放、释放动力学和固态表征（通过差示扫描量热法、X射线衍射、傅里叶变换红外光谱、核磁共振）等主题讨论了通过纳米喷雾干燥生产的口服给药系统。