The present work aimed to prepare new starch-based Pickering emulsions for topical application of resveratrol. A sustained-release profile was observed for up to 12 h. Superior stability was achieved for 60 days at 4 °C and 25 °C compared to −20 °C and 40 °C. Good centrifugal stability and dilution stability were shown at different conditions. The entrapment efficiency (EE) was maintained at over 85% in various situations. DPPH radical scavenging study confirmed that resveratrol-loaded starch-based Pickering emulsions had a more conspicuous sustained-release effect on resveratrol, and the antioxidant capacities of resveratrol were not affected. Compared to the resveratrol ethanol solution, the resveratrol-loaded starch-based Pickering emulsions showed a higher ability to improve skin permeation of resveratrol and significantly enhanced the distribution of resveratrol in the skin as well. These studies demonstrated that starch-based resveratrol-loaded Pickering emulsions might be a promising drug delivery system for topical application of resveratrol.

Graphical abstract

中文翻译：

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负载白藜芦醇的淀粉基 Pickering 乳液的皮肤靶向：制备、表征和评估

目前的工作旨在制备用于白藜芦醇局部应用的新型淀粉基 Pickering 乳液。观察到长达 12 小时的缓释曲线。与 -20 °C 和 40 °C 相比，在 4 °C 和 25 °C 下可保持 60 天的卓越稳定性。在不同条件下均表现出良好的离心稳定性和稀释稳定性。在各种情况下，包封率（EE）均保持在 85% 以上。DPPH自由基清除研究证实，负载白藜芦醇的淀粉基Pickering乳液对白藜芦醇具有更显着的缓释作用，而白藜芦醇的抗氧化能力不受影响。与白藜芦醇乙醇溶液相比，负载白藜芦醇的淀粉基 Pickering 乳液显示出更高的改善白藜芦醇皮肤渗透的能力，并显着增强了白藜芦醇在皮肤中的分布。这些研究表明，基于淀粉的白藜芦醇负载 Pickering 乳液可能是一种用于白藜芦醇局部应用的有前途的给药系统。

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