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A local multi-transmit coil combined with a high-density receive array for cerebellar fMRI at 7 T
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2021-07-06 , DOI: 10.1002/nbm.4586 Nikos Priovoulos 1 , Thomas Roos 1 , Özlem Ipek 2 , Ettore F Meliado 3 , Richard O Nkrumah 2 , Dennis W J Klomp 3 , Wietske van der Zwaag 1
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2021-07-06 , DOI: 10.1002/nbm.4586 Nikos Priovoulos 1 , Thomas Roos 1 , Özlem Ipek 2 , Ettore F Meliado 3 , Richard O Nkrumah 2 , Dennis W J Klomp 3 , Wietske van der Zwaag 1
Affiliation
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The human cerebellum is involved in a wide array of functions, ranging from motor control to cognitive control, and as such is of great neuroscientific interest. However, its function is underexplored in vivo, due to its small size, its dense structure and its placement at the bottom of the brain, where transmit and receive fields are suboptimal. In this study, we combined two dense coil arrays of 16 small surface receive elements each with a transmit array of three antenna elements to improve BOLD sensitivity in the human cerebellum at 7 T. Our results showed improved B1+ and SNR close to the surface as well as g-factor gains compared with a commercial coil designed for whole-head imaging. This resulted in improved signal stability and large gains in the spatial extent of the activation close to the surface (<3.5 cm), while good performance was retained deeper in the cerebellum. Modulating the phase of the transmit elements of the head coil to constructively interfere in the cerebellum improved the B1+, resulting in a temporal SNR gain. Overall, our results show that a dedicated transmit array along with the SNR gains of surface coil arrays can improve cerebellar imaging, at the cost of a decreased field of view and increased signal inhomogeneity.
中文翻译：
7 T 小脑 fMRI 的局部多发射线圈与高密度接收阵列相结合
人类小脑涉及广泛的功能，从运动控制到认知控制，因此具有极大的神经科学兴趣。然而，由于其体积小、结构致密以及位于大脑底部，其在体内的功能尚未得到充分探索，在大脑底部，发射和接收场不是最理想的。在这项研究中，我们将两个由 16 个小型表面接收元件组成的密集线圈阵列与一个由三个天线元件组成的发射阵列相结合，以提高人类小脑在 7 T 时的 BOLD 灵敏度。我们的结果显示接近表面的B 1 +和 SNR 得到改善以及g与为全头成像设计的商用线圈相比，系数增益。这导致信号稳定性得到改善，并且在靠近表面（<3.5 cm）的激活空间范围内获得了很大的增益，而在小脑更深处保持了良好的性能。调制头部线圈的发射元件的相位以建设性地干扰小脑改善了B 1 +，从而导致时间 SNR 增益。总体而言，我们的结果表明，专用发射阵列以及表面线圈阵列的 SNR 增益可以改善小脑成像，但代价是视野减小和信号不均匀性增加。
更新日期：2021-07-06
中文翻译：
7 T 小脑 fMRI 的局部多发射线圈与高密度接收阵列相结合
人类小脑涉及广泛的功能，从运动控制到认知控制，因此具有极大的神经科学兴趣。然而，由于其体积小、结构致密以及位于大脑底部，其在体内的功能尚未得到充分探索，在大脑底部，发射和接收场不是最理想的。在这项研究中，我们将两个由 16 个小型表面接收元件组成的密集线圈阵列与一个由三个天线元件组成的发射阵列相结合，以提高人类小脑在 7 T 时的 BOLD 灵敏度。我们的结果显示接近表面的B 1 +和 SNR 得到改善以及g与为全头成像设计的商用线圈相比，系数增益。这导致信号稳定性得到改善，并且在靠近表面（<3.5 cm）的激活空间范围内获得了很大的增益，而在小脑更深处保持了良好的性能。调制头部线圈的发射元件的相位以建设性地干扰小脑改善了B 1 +，从而导致时间 SNR 增益。总体而言，我们的结果表明，专用发射阵列以及表面线圈阵列的 SNR 增益可以改善小脑成像，但代价是视野减小和信号不均匀性增加。
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