Abstract

Purpose

Microwave ablation combined with concurrent biopsy has been used for lung cancer. Frozen section (FS) diagnosis is an important supplement for the final pathology (FP). Thus, a retrospective study was conducted to evaluate the concordance between FS examination and FP in the computed tomography (CT)-guided biopsy of lung cancer.

Materials and methods

Patients who underwent percutaneous transthoracic needle lung biopsies and were diagnosed using both intraoperative FS examination and FP were retrospectively enrolled. Concordance between FS findings and FP in the diagnosis of malignant lung cancer and the definitive histology types were recorded.

Results

Overall, 163 patients were enrolled. The concordance rate in the diagnosis of malignant tumors was 96.3%. The definitive histology types were concordant between FS examinations and FP in 112 patients (68.7%). Lung cancers undefined with FS but diagnosed as adenocarcinoma with FP were the most common type, observed in 18 patients. The concordance in the histology type was lower for those requiring immunohistochemistry for FP diagnoses (47.3 vs. 79.6%, p < 0.000). Concordance rates differed for the different histology types diagnosed using FP (adenocarcinoma vs. squamous cell carcinoma vs. small-cell lung cancer vs. others, 76.6 vs. 56.2 vs. 69.2 vs. 0.0%, p < 0.000).

Conclusions

FS was inferior to FP in the diagnosis of definitive histology types, but had a high concordance with FP in the diagnosis of malignant lung cancer.

中文翻译：

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同步活检和微波消融是否可靠？CT引导下肺癌活检中冰冻切片检查与最终病理的一致性

摘要

目的

微波消融联合同步活检已用于肺癌。冰冻切片（FS）诊断是最终病理学（FP）的重要补充。因此，进行了一项回顾性研究以评估计算机断层扫描 (CT) 引导的肺癌活检中 FS 检查和 FP 之间的一致性。

材料和方法

回顾性纳入接受经皮经胸针肺活检并使用术中 FS 检查和 FP 诊断的患者。记录了 FS 发现和 FP 在恶性肺癌诊断和确定的组织学类型中的一致性。

结果

总共招募了 163 名患者。恶性肿瘤诊断的符合率为96.3%。112 名患者 (68.7%) 的 FS 检查和 FP 的最终组织学类型一致。在 18 名患者中观察到的肺癌未定义为 FS 但被诊断为具有 FP 的腺癌是最常见的类型。对于需要免疫组织化学进行 FP 诊断的患者，组织学类型的一致性较低（47.3对79.6%，p  < 0.000）。使用 FP 诊断的不同组织学类型的一致性率不同（腺癌vs.鳞状细胞癌vs.小细胞肺癌vs.其他，76.6 vs. 56.2 vs. 69.2与0.0%，p  < 0.000）。

结论

FS 在明确组织学类型的诊断中不如 FP，但在恶性肺癌的诊断中与 FP 具有较高的一致性。