Laboratory mice are a crucial preclinical model system for investigating bone marrow adipocyte (BMAd)-bone and BMAd-hematopoiesis interactions. In this review, we evaluate the suitability of mice to model common human diseases related to osteopenia or hematopoietic disorders, point out consistencies and discrepancies among different studies, and provide insights into model selection. Species, age, sex, skeletal site, and treatment protocol should all be considered when designing future studies.

中文翻译：

---

研究骨髓脂肪细胞如何影响骨骼和造血细胞的临床前模型

实验室小鼠是研究骨髓脂肪细胞 (BMad)-骨和 BMAd-造血相互作用的关键临床前模型系统。在这篇综述中，我们评估了小鼠模拟与骨质减少或造血障碍相关的常见人类疾病的适用性，指出了不同研究之间的一致性和差异，并为模型选择提供了见解。在设计未来的研究时，应考虑物种、年龄、性别、骨骼部位和治疗方案。