In this study, the novel poly (lactic-co-glycolic acid)-Hydroxyapatite nanoparticles (PLGA/HA) nanocomposite scaffolds were fabricated with solvent casting and particulate leaching (SCPL) method. The role of sodium chloride (NaCl) particles with diameters of 250-400 μm as porogen agent in the mechanical strength of the produced scaffolds was evaluated. The prepared scaffolds were characterized using Fourier transform infrared (FT-IR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA) and compressive tests. The results showed the high compressive strength and homogenous porous structures for PLGA/HA nanocomposite scaffolds compared to pure PLGA due to the presence of HA nanoparticles in nanocomposites. Furthermore, the compressive strength of nanocomposite scaffolds increased by varying the weight ratio of hydroxyapatite nanoparticles to polymer (0, 20, 40 wt%) at constant salt ratio and decreased by increasing the weight ratio of salt particles to polymer from 1 to 3 wt% due to more porosity in nanocomposite scaffolds. These results confirmed that not only the nanocomposite scaffolds exhibited high mechanical properties, homogenous structures, as well as good porosity but also, they could be useful for bone tissue application.

在这项研究中，采用溶剂浇铸和颗粒浸出（SCPL）方法制造了新型聚（乳酸-乙醇酸）-羟基磷灰石纳米粒子（PLGA/HA）纳米复合材料支架。氯化钠（NaCl）颗粒的作用，直径为 250-400 μm 作为致孔剂对所生产的支架的机械强度进行了评估。使用傅里叶变换红外（FT-IR）、X射线衍射（XRD）、扫描电子显微镜（SEM）、热重分析（TGA）和压缩测试对制备的支架进行表征。结果表明，由于纳米复合材料中存在 HA 纳米颗粒，PLGA/HA 纳米复合材料支架与纯 PLGA 相比具有高抗压强度和均匀的多孔结构。此外，纳米复合材料支架的抗压强度通过改变羟基磷灰石纳米颗粒与聚合物的重量比（0、20、40 wt%）在恒定的盐比下增加，并通过将盐颗粒与聚合物的重量比从 1% 增加到 3% 降低。由于纳米复合材料支架的孔隙率更高。