In this work, the solubility of amitriptyline hydrochloride (AMT) in 13 monosolvents was experimentally measured in the temperatures ranging from 283.15 to 323.15 K under atmospheric pressure with the aid of laser dynamic solubility monitor devices. The solubility as a function of temperature in different monosolvents was regressed using two activity coefficient models (Wilson and nonrandom two liquid (NRTL)) and three semiempirical equations (modified Apelblat, three-parameter Van’t Hoff, and λh), Based on the solubility data and the regression parameters of the Wilson model, the mixing thermodynamic properties (mixing Gibbs energy, mixing enthalpy, mixing entropy) as well as the activity coefficient and the reduced excess enthalpy at infinitesimal concentration were evaluated.

中文翻译：

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盐酸阿米替林在283.15–323.15 K温度下在13种纯溶剂中的溶解度测定和热力学模型

在这项工作中，借助于激光动态溶解度监测装置，在大气压下，在283.15至323.15 K的温度范围内，通过实验测量了阿米替林盐酸盐（AMT）在13种单溶剂中的溶解度。如在不同monosolvents温度的函数的溶解度使用两种活度系数模型（Wilson和非随机两液体（NRTL））和三个半经验公式（改性Apelblat，三参数范特霍夫，λ倒退ħ），基于评估了威尔逊模型的溶解度数据和回归参数，评估了混合热力学性质（混合吉布斯能量，混合焓，混合熵）​​以及在最小浓度下的活度系数和降低的过量焓。