Intraoperative electrocorticography (ECoG) captures neural information from the surface of the cerebral cortex during surgeries such as resections for intractable epilepsy and tumors. Current clinical ECoG grids come in evenly spaced, millimeter‐sized electrodes embedded in silicone rubber. Their mechanical rigidity and fixed electrode spatial resolution are common shortcomings reported by the surgical teams. Here, advances in soft neurotechnology are leveraged to manufacture conformable subdural, thin‐film ECoG grids, and evaluate their suitability for translational research. Soft grids with 0.2 to 10 mm electrode pitch and diameter are embedded in 150 µm silicone membranes. The soft grids are compatible with surgical handling and can be folded to safely interface hidden cerebral surface such as the Sylvian fold in human cadaveric models. It is found that the thin‐film conductor grids do not generate diagnostic‐impeding imaging artefacts (<1 mm) nor adverse local heating within a standard 3T clinical magnetic resonance imaging scanner. Next, the ability of the soft grids to record subdural neural activity in minipigs acutely and two weeks postimplantation is validated. Taken together, these results suggest a promising future alternative to current stiff electrodes and may enable the future adoption of soft ECoG grids in translational research and ultimately in clinical settings.

中文翻译：

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用于转化研究的 MRI 兼容且适形皮质电图网格

术中皮层电图（ECoG）可在顽固性癫痫和肿瘤切除术等手术过程中捕获大脑皮层表面的神经信息。目前的临床 ECoG 网格采用嵌入硅橡胶中的均匀间隔、毫米大小的电极。它们的机械刚性和固定电极空间分辨率是手术团队报告的常见缺点。在这里，利用软神经技术的进步来制造舒适的硬膜下薄膜 ECoG 网格，并评估其对转化研究的适用性。电极间距和直径为 0.2 至 10 mm 的软网格嵌入 150 µm 硅胶膜中。软网格与手术操作兼容，并且可以折叠以安全地连接隐藏的大脑表面，例如人体尸体模型中的侧裂褶皱。研究发现，薄膜导体网格不会在标准 3T 临床磁共振成像扫描仪中产生妨碍诊断的成像伪影（<1 mm），也不会产生不利的局部加热。接下来，验证了软网格在小型猪中敏锐记录植入后两周硬膜下神经活动的能力。总而言之，这些结果表明了一种有前景的未来替代当前僵硬电极的方法，并且可能使软 ECoG 网格未来在转化研究中以及最终在临床环境中得到采用。