Abstract Tau protein neurofibrillary tangles (NFT) are closely linked to neuronal/synaptic loss and cognitive decline in Alzheimer's disease (AD) and related dementias. Our knowledge of the pattern of NFT progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in AD, is based on conventional 2D histology studies that only sample the brain sparsely. To address this limitation, ex vivo MRI and dense serial histological imaging in 18 human medial temporal lobe (MTL) specimens were used to construct 3D quantitative maps of NFT burden in the MTL at individual and group levels. These maps reveal significant variation in NFT burden along the anterior-posterior axis. While early NFT pathology is thought to be confined to the transentorhinal region, we find similar levels of NFT burden in this region and other MTL subregions, including amygdala, temporopolar cortex, and subiculum/CA1.

中文翻译：

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人内侧颞叶神经原纤维缠结的3D映射

摘要Tau蛋白神经原纤维缠结（NFT）与阿尔茨海默氏病（AD）和相关痴呆症的神经元/突触丧失和认知能力下降密切相关。我们对人脑中NFT进行模式的了解，对成​​像生物标志物的发展和AD体内成像研究的解释至关重要，是基于仅对大脑进行稀疏采样的常规2D组织学研究。为了解决这一局限性，我们使用18个人类内侧颞叶（MTL）标本中的离体MRI和密集系列组织学成像技术，在个体和组水平上构建了MTL中NFT负担的3D定量图。这些图揭示了NFT负担沿前后轴的显着变化。尽管人们认为早期的NFT病理仅限于跨肠上皮区，