Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-11-30 , DOI: 10.2174/1389557520666200729162510 Olagoke Zacchaeus Olatunde 1 , Jianping Yong 2 , Canzhong Lu 1
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Anticancer drugs based on the microtubules target are potent mitotic spindle poison agents, which interact directly with the microtubules, and were classified as microtubule-stabilizing agents and microtubule-destabilizing agents. Researchers have worked tremendously towards the improvements of anticancer drugs, in terms of improving the efficacy, solubility and reducing the side effects, which brought about advancement in chemotherapy. In this review, we focused on describing the discovery, structures and functions of the microtubules as well as the progress of anticancer agents related to the microtubules, which will provide adequate references for researchers.
中文翻译：
与微管靶标相关的抗癌药的研究进展
基于微管目标的抗癌药是有效的有丝分裂纺锤体毒物，它们直接与微管相互作用，并被分类为微管稳定剂和微管去稳定剂。在提高功效，溶解度和减少副作用方面，研究人员为改进抗癌药物做出了巨大的努力，这带来了化学疗法的进步。在这篇综述中，我们集中于描述微管的发现，结构和功能以及与微管有关的抗癌剂的进展，这将为研究人员提供足够的参考。
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