The abnormal growth of tissue, called pannus, is frequently found in patients who have an implanted prosthetic heart valve. Its growth is related to the valve dysfunction and disturbed blood flow in the aorta. We performed in vitro experiments to demonstrate the effects of pannus formation on hemodynamics and valvular function. The results showed that the opening angle of the heart valve changes depending on the size and shape of the pannus. The circular pannus decreased the maximum opening angle of the heart valve. Although the opening motion of the valve was not affected by the semi-circular pannus, one of the valve leaflets obstructed by the semi-circular pannus had a closing dysfunction during the cardiac cycle, implying aortic insufficiency and regurgitation in the patients with this type of pannus formation. The experimentally measured pressure gradient and velocity-based transvalvular pressure gradient estimation increased with the growth of the pannus, although a discrepancy between the two estimations was observed.

在植入人工心脏瓣膜的患者中经常发现被称为血管nu的组织异常生长。它的生长与主动脉瓣功能障碍和血液流动受阻有关。我们进行了体外实验，以证明血管nu的形成对血液动力学和瓣膜功能的影响。结果表明，心脏瓣膜的打开角度随the的大小和形状而变化。圆形pan减小了心脏瓣膜的最大打开角度。尽管瓣膜的打开动作不受半圆形血管nu的影响，但其中一个被半圆形血管nu阻塞的瓣膜小叶在心动周期中具有关闭功能障碍，这意味着这种类型的患者的主动脉瓣关闭不全和反流。 nu形成。