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Enantioselective epoxidation by the chiral auxiliary approach: Asymmetric total synthesis of (+)‐Ambrisentan
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-12-31 , DOI: 10.1002/jhet.4223
Madhu Madasu 1 , Sai Reddy Doda 1 , Prem Kumar Begari 1 , Krishna Rao Dasari 1 , Gangadhar Thalari 2 , Sudhakar Kadari 2 , J. S. Yadav 1
Affiliation  

Enantioselective and a highly concise total synthesis of Ambrisentan are described. The chiral auxiliary controlled enantioselective epoxidation (Azerad protocol), photochemical regioselective epoxide opening, and base mediated ester hydrolysis reactions are the key reactions.

中文翻译:

手性辅助方法的对映选择性环氧化:(+)-Ambrisentan的不对称全合成

描述了Ambrisentan的对映选择性和高度简洁的总合成方法。手性辅助控制的对映体选择性环氧化(Azerad协议),光化学区域选择性环氧化物开口和碱介导的酯水解反应是关键反应。
更新日期:2020-12-31
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