Enantioselective epoxidation by the chiral auxiliary approach: Asymmetric total synthesis of (+)‐Ambrisentan,Journal of Heterocyclic Chemistry

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Enantioselective epoxidation by the chiral auxiliary approach: Asymmetric total synthesis of (+)‐Ambrisentan
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-12-31 , DOI: 10.1002/jhet.4223
Madhu Madasu ₁ , Sai Reddy Doda ₁ , Prem Kumar Begari ₁ , Krishna Rao Dasari ₁ , Gangadhar Thalari ₂ , Sudhakar Kadari ₂ , J. S. Yadav ₁

Affiliation

Enantioselective and a highly concise total synthesis of Ambrisentan are described. The chiral auxiliary controlled enantioselective epoxidation (Azerad protocol), photochemical regioselective epoxide opening, and base mediated ester hydrolysis reactions are the key reactions.

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