Quercetin, a naturally occurring dietary flavonoid, is well known to ameliorate chronic diseases and aging processes in humans, and its antiviral properties have been investigated in numerous studies. In silico and in vitro studies demonstrated that quercetin can interfere with various stages of the coronavirus entry and replication cycle such as PLpro, 3CLpro, and NTPase/helicase. Due to its pleiotropic activities and lack of systemic toxicity, quercetin and its derivatives may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections. There is evidence that quercetin in combination with, for example, vitamins C and D, may exert a synergistic antiviral action that may provide either an alternative or additional therapeutic/preventive option due to overlapping antiviral and immunomodulatory properties. This review summarizes the antiviral significance of quercetin and proposes a possible strategy for the effective utilization of natural polyphenols in our daily diet for the prevention of viral infection.

槲皮素是一种天然存在的饮食类黄酮，可改善人类的慢性疾病和衰老过程，其抗病毒特性已在众多研究中得到研究。在计算机和体外研究中表明，槲皮素可以干扰冠状病毒进入和复制周期的各个阶段，例如PLpro，3CLpro和NTPase /解旋酶。由于槲皮素的活性和缺乏全身毒性，槲皮素及其衍生物可能代表了有待在未来的临床试验中测试的目标化合物，从而丰富了针对日冕病毒感染的药库。有证据表明槲皮素与维生素C和D相结合，由于重叠的抗病毒和免疫调节特性，可发挥协同抗病毒作用，可提供替代或附加的治疗/预防选择。这篇综述总结了槲皮素的抗病毒意义，并提出了在我们的日常饮食中有效利用天然多酚来预防病毒感染的可能策略。