Behavioral addictions can come in many forms, including overeating, gambling and overexercising. All addictions share a common mechanism involving activation of the natural reward circuit and reinforcement learning, but the extent to which motivation for natural and drug rewards share similar neurogenetic mechanisms remains unknown. A unique mouse genetic model in which four replicate lines of female mice were selectively bred (>76 generations) for high voluntary wheel running (High Runner or HR lines) alongside four non‐selected control (C) lines were used to test the hypothesis that high motivation for exercise is associated with greater reward for cocaine (20 mg/kg) and methylphenidate (10 mg/kg) using the conditioned place preference (CPP) test. HR mice run ~three times as many revolutions/day as C mice, but the extent to which they have increased motivation for other rewards is unknown. Both HR and C mice displayed significant CPP for cocaine and methylphenidate, but with no statistical difference between linetypes for either drug. Taken together, results suggest that selective breeding for increased voluntary running has modified the reward circuit in the brain in a way that increases motivation for running without affecting cocaine or methylphenidate reward.

中文翻译：

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选择性培育高自愿车轮运行行为的雌性小鼠对可卡因和哌醋甲酯的条件性位置偏好

行为成瘾可以有多种形式，包括暴饮暴食、赌博和过度锻炼。所有成瘾都有一个共同的机制，涉及激活自然奖励回路和强化学习，但自然奖励和药物奖励的动机在多大程度上共享相似的神经遗传机制仍然未知。一个独特的小鼠遗传模型，其中有四个复制品系的雌性小鼠被选择性繁殖（> 76 代）以进行高自愿轮跑（High Runner 或 HR 系）以及四个非选择的对照（C）系，用于检验以下假设：使用条件性位置偏好 (CPP) 测试，运动的高动机与可卡因 (20 mg/kg) 和哌醋甲酯 (10 mg/kg) 的更大奖励有关。HR 小鼠每天的转数是 C 小鼠的三倍，但是他们在多大程度上增加了其他奖励的动机是未知的。HR 和 C 小鼠都显示出显着的可卡因和哌醋甲酯 CPP，但两种药物的线型之间没有统计学差异。总之，结果表明，增加自愿跑步的选择性育种已经改变了大脑中的奖励回路，从而增加了跑步的动力而不影响可卡因或哌醋甲酯的奖励。