Massive bleeding and wound infection after tissue trauma are the major dangerous factors of casualties in disasters; hence, first‐aid supplies that can greatly achieve wound closure and effectively control the hemorrhage and infection are urgently needed. Although existing tissue adhesives can adhere to the tissue surfaces and achieve rapid wound closure, most of them have limited hemostatic and antibacterial capacities, making them unsuitable as the first‐aid tissue adhesives. In this study, inspired by the inherent hemostatic and antibacterial capacities of chitosan and the excellent tissue integration capacity originating from a Schiff base reaction, liquid bandage (LBA), an in situ imine crosslinking‐based photoresponsive chitosan hydrogel (NB‐CMC/CMC hydrogel), is developed for emergency wound management. Upon UV irradiation, o‐nitrobenzene in modified carboxymethyl chitosan (CMC) converts to o‐nitrosobenzaldehyde that subsequently crosslinks with amino groups on tissue surface, which endows the LBA with superior tissue adhesive performance. LBA's hemostatic and antibacterial properties can be tuned by the mass ratio of NB‐CMC/CMC. Moreover, it exhibits satisfactory biocompatibility, biodegradability, and the capability to enhance wound healing process. This study sheds new light on the development of a multifunctional hydrogel‐based first‐aid tissue adhesive that can achieve robust tissue adhesion, effectively control bleeding, prevent bacterial infection, and promote wound healing.

中文翻译：

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液体绷带可作为急救组织胶粘剂获得稳定的胶粘剂，止血和抗菌性能

组织创伤后的大量出血和伤口感染是灾难中造成人员伤亡的主要危险因素。因此，迫切需要能够极大地闭合伤口并有效控制出血和感染的急救用品。尽管现有的组织粘合剂可以粘附到组织表面并实现快速伤口闭合，但是它们大多数具有有限的止血和抗菌能力，因此不适合用作急救组织粘合剂。在这项研究中，壳聚糖固有的止血和抗菌能力以及源自席夫碱反应，液体绷带（LBA），基于亚胺交联的光敏壳聚糖水凝胶（NB‐CMC / CMC水凝胶）产生的出色的组织整合能力启发了本研究），用于紧急伤口处理。在紫外线照射下Ó硝基苯在改性羧甲基壳聚糖（CMC）转换到ö -nitrosobenzaldehyde其随后与组织表面，这赋予了优异的组织粘合剂性能的LBA氨基交联。LBA的止血和抗菌性能可以通过NB-CMC / CMC的质量比进行调整。而且，它表现出令人满意的生物相容性，生物降解性和增强伤口愈合过程的能力。这项研究为基于多功能水凝胶的急救组织粘合剂的开发提供了新的亮点，该粘合剂可实现牢固的组织粘合，有效控制出血，防止细菌感染并促进伤口愈合。