While there are several known causes for recurrent pregnancy loss (RPL), about 50% are unexplained (uRPL), and in these cases, an aberrant immune regulation seems to be involved. Although fetally derived trophoblast cells have a key role in immune regulation, it is difficult to study their immune function during pregnancy, and it is not known whether trophoblast function may be an inherent aberration in uRPL or whether it is associated with the outcome of the current pregnancy.

中文翻译：

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尽管有不明原因的复发性流产史，但通过绒毛膜绒毛取样获得的妊娠早期滋养层细胞在成功怀孕中保持耐受性和蛋白质组学特征。

虽然有几个已知的复发性流产 (RPL) 原因，但大约 50% 是无法解释的 (uRPL)，在这些情况下，似乎涉及异常的免疫调节。虽然胎儿来源的滋养层细胞在免疫调节中具有关键作用，但很难研究其在妊娠期的免疫功能，并且尚不清楚滋养层功能是否可能是 uRPL 的固有畸变或是否与当前的结果相关。怀孕。