As a new strategy for wound management, probiotics are highly sensitive to the external environment during use. In this study, an attempt is made to apply oxidized Bletilla striata polysaccharide (OBSP) hydrogel as a delivery system to put up a physical barrier to probiotics. Bletilla striata, as a famous traditional Chinese medicine, has been widely used for over 1500 years to promote wound healing. Firstly, probiotic-bound OBSP-Chitosan composite hydrogel (OBSP-CS-LP hydrogel) was prepared by a simple and environmentally friendly approach. Subsequently, the SEM image, swelling and rheological properties of the OBSP-CS-LP hydrogel were investigated. Notably, composite probiotics to wounds are an attractive novel intervention that significantly improves the antibacterial properties of the hydrogel and avoids the pitfalls of many antibiotic therapies. Furthermore, the full-thickness skin defect model in vivo indicated an outstanding wound healing efficacy. Therefore, OBSP-CS-LP hydrogel could be applied as a promising dressing in the wound healing.

作为伤口处理的新策略，益生菌在使用过程中对外部环境高度敏感。在这项研究中，尝试将氧化的白let多糖（OBSP）水凝胶用作递送系统，以对益生菌建立物理屏障。白let作为一种著名的中药，在促进伤口愈合方面已有1500多年的历史了。首先，通过一种简单且环保的方法制备了结合益生菌的OBSP-壳聚糖复合水凝胶（OBSP-CS-LP水凝胶）。随后，研究了OBSP-CS-LP水凝胶的SEM图像，溶胀和流变性。值得注意的是，针对伤口的复合益生菌是一种有吸引力的新型干预手段，可显着改善水凝胶的抗菌性能并避免许多抗生素疗法的弊端。此外，体内全层皮肤缺损模型显示出优异的伤口愈合功效。因此，OBSP-CS-LP水凝胶可作为伤口愈合中有希望的敷料。