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Modifying the tumour microenvironment and reverting tumour cells: New strategies for treating malignant tumours
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-06-26 , DOI: 10.1111/cpr.12865
Ya Qi Cheng 1 , Shou Bi Wang 1 , Jia Hui Liu 2 , Lin Jin 1 , Ying Liu 1 , Chao Yang Li 1 , Ya Ru Su 1 , Yu Run Liu 1 , Xuan Sang 1 , Qi Wan 1 , Chang Liu 1 , Liu Yang 1 , Zhi Chong Wang 1
Affiliation  

Abstract The tumour microenvironment (TME) plays a pivotal role in tumour fate determination. The TME acts together with the genetic material of tumour cells to determine their initiation, metastasis and drug resistance. Stromal cells in the TME promote the growth and metastasis of tumour cells by secreting soluble molecules or exosomes. The abnormal microenvironment reduces immune surveillance and tumour killing. The TME causes low anti‐tumour drug penetration and reactivity and high drug resistance. Tumour angiogenesis and microenvironmental hypoxia limit the drug concentration within the TME and enhance the stemness of tumour cells. Therefore, modifying the TME to effectively attack tumour cells could represent a comprehensive and effective anti‐tumour strategy. Normal cells, such as stem cells and immune cells, can penetrate and disrupt the abnormal TME. Reconstruction of the TME with healthy cells is an exciting new direction for tumour treatment. We will elaborate on the mechanism of the TME to support tumours and the current cell therapies for targeting tumours and the TME—such as immune cell therapies, haematopoietic stem cell (HSC) transplantation therapies, mesenchymal stem cell (MSC) transfer and embryonic stem cell‐based microenvironment therapies—to provide novel ideas for producing breakthroughs in tumour therapy strategies.

中文翻译:

改变肿瘤微环境并恢复肿瘤细胞:治疗恶性肿瘤的新策略

摘要 肿瘤微环境(TME)在决定肿瘤命运中起关键作用。TME 与肿瘤细胞的遗传物质共同作用,以确定它们的起始、转移和耐药性。TME中的基质细胞通过分泌可溶性分子或外泌体促进肿瘤细胞的生长和转移。异常的微环境减少了免疫监视和肿瘤杀伤。TME导致抗肿瘤药物渗透性和反应性低,耐药性高。肿瘤血管生成和微环境缺氧限制了 TME 内的药物浓度并增强了肿瘤细胞的干性。因此,修饰 TME 以有效攻击肿瘤细胞可以代表一种全面有效的抗肿瘤策略。正常细胞,如干细胞和免疫细胞,可以穿透和破坏异常的 TME。用健康细胞重建 TME 是肿瘤治疗的一个令人兴奋的新方向。我们将详细阐述 TME 支持肿瘤的机制以及当前针对肿瘤和 TME 的细胞疗法——例如免疫细胞疗法、造血干细胞 (HSC) 移植疗法、间充质干细胞 (MSC) 转移和胚胎干细胞基于微环境疗法——为在肿瘤治疗策略上取得突破提供新的思路。
更新日期:2020-06-26
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