Functional neuroimaging research has consistently associated brain structures within the default mode network (DMN) and frontoparietal network (FPN) with mind‐wandering. Targeted lesion research has documented impairments in mind‐wandering after damage to the medial prefrontal cortex (mPFC) and hippocampal regions associated with the DMN. However, no lesion studies to date have applied lesion network mapping to identify common networks associated with deficits in mind‐wandering. In lesion network mapping, resting‐state functional connectivity data from healthy participants are used to infer which brain regions are functionally connected to each lesion location from a sample with brain injury. In the current study, we conducted a lesion network mapping analysis to test the hypothesis that lesions affecting the DMN and FPN would be associated with diminished mind‐wandering. We assessed mind‐wandering frequency on the Imaginal Processes Inventory (IPI) in participants with brain injury (n = 29) and healthy comparison participants without brain injury (n = 19). Lesion network mapping analyses showed the strongest association of reduced mind‐wandering with the left inferior parietal lobule within the DMN. In addition, traditional lesion symptom mapping results revealed that reduced mind‐wandering was associated with lesions of the dorsal, ventral, and anterior sectors of mPFC, parietal lobule, and inferior frontal gyrus in the DMN (p < 0.05 uncorrected). These findings provide novel lesion support for the role of the DMN in mind‐wandering and contribute to a burgeoning literature on the neural correlates of spontaneous cognition.

中文翻译：

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病变网络映射表明走神与默认模式网络相关联。

功能性神经影像研究始终将默认模式网络 (DMN) 和额顶网络 (FPN) 中的大脑结构与走神联系起来。有针对性的病变研究记录了在内侧前额叶皮层 (mPFC) 和与 DMN 相关的海马区受损后的走神障碍。然而，迄今为止，还没有病变研究应用病变网络映射来识别与走神缺陷相关的常见网络。在病变网络映射中，来自健康参与者的静息状态功能连接数据用于推断哪些大脑区域在功能上与脑损伤样本中的每个病变位置相连。在目前的研究中，我们进行了病变网络映射分析，以检验影响 DMN 和 FPN 的病变与减少走神有关的假设。我们评估了脑损伤参与者的想象过程清单 (IPI) 的走神频率。n  = 29) 和没有脑损伤的健康比较参与者 ( n  = 19)。病变网络映射分析显示，减少走神与 DMN 内的左顶叶下小叶之间的关联最强。此外，传统的病变症状映射结果显示，减少走神与 mPFC 的背侧、腹侧和前部、顶叶小叶和 DMN 中的额下回的病变有关（p  < 0.05 未校正）。这些发现为 DMN 在走神中的作用提供了新的病变支持，并有助于关于自发认知的神经相关性的新兴文献。