Emerging Approaches to Functionalizing Cell Membrane-Coated Nanoparticles,Biochemistry

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Emerging Approaches to Functionalizing Cell Membrane-Coated Nanoparticles
Biochemistry ( IF 2.9 ) Pub Date : 2020-05-26 , DOI: 10.1021/acs.biochem.0c00343
Xiangzhao Ai ₁ , Shuyan Wang ₁ , Yaou Duan ₁ , Qiangzhe Zhang ₁ , Maggie S Chen ₁ , Weiwei Gao ₁ , Liangfang Zhang ₁

Affiliation

There has been significant interest in developing cell membrane-coated nanoparticles due to their unique abilities of biomimicry and biointerfacing. As the technology progresses, it becomes clear that the application of these nanoparticles can be drastically broadened if additional functions beyond those derived from the natural cell membranes can be integrated. Herein, we summarize the most recent advances in the functionalization of cell membrane-coated nanoparticles. In particular, we focus on emerging methods, including (1) lipid insertion, (2) membrane hybridization, (3) metabolic engineering, and (4) genetic modification. These approaches contribute diverse functions in a nondisruptive fashion while preserving the natural function of the cell membranes. They also improve on the multifunctional and multitasking ability of cell membrane-coated nanoparticles, making them more adaptive to the complexity of biological systems. We hope that these approaches will serve as inspiration for more strategies and innovations to advance cell membrane coating technology.

中文翻译：

细胞膜涂层纳米颗粒功能化的新兴方法

由于其独特的仿生和生物界面能力，人们对开发细胞膜涂层纳米颗粒产生了浓厚的兴趣。随着技术的进步，很明显，如果能够集成天然细胞膜之外的附加功能，这些纳米颗粒的应用可以大大拓宽。在此，我们总结了细胞膜涂层纳米颗粒功能化的最新进展。我们特别关注新兴方法，包括（1）脂质插入、（2）膜杂交、（3）代谢工程和（4）遗传修饰。这些方法以非破坏性的方式提供多种功能，同时保留细胞膜的自然功能。它们还提高了细胞膜涂层纳米粒子的多功能和多任务处理能力，使它们更能适应生物系统的复杂性。我们希望这些方法能够为更多策略和创新提供灵感，以推进细胞膜涂层技术。

更新日期：2020-05-26

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