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Inactivation of airborne bacteria by plasma treatment and ionic wind for indoor air cleaning
Plasma Processes and Polymers ( IF 3.5 ) Pub Date : 2020-05-25 , DOI: 10.1002/ppap.202000027
Franziska Prehn 1 , Eric Timmermann 1 , Manfred Kettlitz 1 , Katharina Schaufler 2 , Sebastian Günther 2 , Veronika Hahn 1
Affiliation  

Airborne bacteria are a general problem in medical or health care facilities with a high risk for nosocomial infections. Rooms with a continuous airflow, such as operation theaters, are of particular importance due to a possible dissemination and circulation of pathogens including multidrug‐resistant microorganisms. In this regard, a cold atmospheric‐pressure plasma (CAP) may be a possibility to support usual disinfection procedures due to its decontaminating properties. The aim of this study was to determine the antimicrobial efficacy of a plasma decontamination module that included a dielectric barrier discharge for plasma generation. Experimental parameters such as an airflow velocity of 4.5 m/s and microbial contaminations of approximately 6,000 colony‐forming units (cfu)/m3 were used to simulate practical conditions of a ventilation system in an operating theater. The apathogenic microorganism Escherichia coli K12 DSM 11250/NCTC 10538 and the multidrug‐resistant strains E. coli 21181 and 21182 (isolated from patients) were tested to determine the antimicrobial efficacy. In summary, the number of cfu was reduced by 31–89% for the tested E. coli strains, whereby E. coli K12 was the most susceptible strain toward inactivation by the designed plasma module. A possible correlation between the number or kind of resistances and susceptibility against plasma was discussed. The inactivation of microorganisms was affected by plasma intensity and size of the plasma treatment area. In addition, the differences of the antimicrobial efficacies caused through the nebulization of microorganisms in front (upstream) or behind (downstream) the plasma source were compared. The presence of ionic wind had no influence on the reduction of the number of cfu for E. coli K12, as the airflow velocity was too high for a successful precipitation, which would be a prerequisite for an increased antimicrobial efficacy. The inactivation of the tested microorganisms confirms the potential of CAP for the improvement of air quality. The scale‐up of this model system may provide a novel tool for an effective air cleaning process.

中文翻译:

通过等离子处理和离子风灭活空气中的细菌,从而清洁室内空气

空气传播细菌是医疗或卫生保健机构中普遍存在的问题,存在医院内感染的高风险。由于手术室等可能传播和传播包括多重耐药性微生物在内的病原体,因此连续不断流动的房间(例如手术室)尤为重要。在这方面,冷的大气压等离子体(CAP)由于其去污特性而可能支持常规的消毒程序。这项研究的目的是确定等离子体净化模块的抗菌功效,该模块包括用于等离子体生成的介电势垒放电。实验参数,例如4.5 m / s的气流速度和大约6,000个菌落形成单位(cfu)/ m 3的微生物污染被用来模拟手术室通风系统的实际情况。测试了无源微生物大肠杆菌K12 DSM 11250 / NCTC 10538和多药耐药菌株大肠杆菌21181和21182(从患者中分离)以确定其抗菌功效。总之,对于测试的大肠杆菌菌株,cfu的数量减少了31–89%,从而使大肠杆菌通过设计的血浆模块,K12是最容易灭活的菌株。讨论了电阻的数量或种类与对血浆的敏感性之间的可能相关性。微生物的灭活受到血浆强度和血浆处理区域大小的影响。另外,比较了由血浆源前面(上游)或后面(下游)的微生物雾化引起的抗菌功效的差异。离子风的存在对减少大肠杆菌的cfu数量没有影响K12,因为气流速度太高而无法成功沉淀,这将是提高抗菌功效的前提。被测微生物的灭活证实了CAP改善空气质量的潜力。该模型系统的放大可能为有效的空气净化过程提供新颖的工具。
更新日期:2020-05-25
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