Iridoids and bis-iridoids from Valeriana jatamansi and their cytotoxicity against human glioma stem cells,Phytochemistry

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Iridoids and bis-iridoids from Valeriana jatamansi and their cytotoxicity against human glioma stem cells
Phytochemistry ( IF 3.2 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.phytochem.2020.112372
Li-Qiu Quan ₁ , Ahmed-Mohamed Hegazy ₂ , Zhi-Jun Zhang ₁ , Xu-Dong Zhao ₃ , Hong-Mei Li ₁ , Rong-Tao Li ₁

Affiliation

An undescribed iridoid (valeridoid A) and five undescribed bis-iridoids (valeridoids B-F), along with four known ones, were isolated from the roots and rhizomes of Valeriana jatamansi. Their structures were elucidated based on 1D and 2D NMR, as well as HRESIMS spectroscopic data. In addition, 8,9-didehydro-7-hydroxydolichodial and valeridoid F were found to inhibit the growth of three human glioma stem cells (GSC-3#, GSC-12# and GSC-18#).

中文翻译：

Valeriana jatamansi 的环烯醚萜类化合物和双环烯醚萜类化合物及其对人神经胶质瘤干细胞的细胞毒性

从 Valeriana jatamansi 的根和根茎中分离出一种未描述的环烯醚萜 (valeridoid A) 和五种未描述的双环烯醚萜 (valeridoids BF)，以及四种已知的环烯醚萜。基于一维和二维核磁共振以及 HRESIMS 光谱数据阐明了它们的结构。此外，发现 8,9-didehydro-7-hydroxydolichodial 和 valeridoid F 可抑制三种人类神经胶质瘤干细胞（GSC-3#、GSC-12# 和 GSC-18#）的生长。

更新日期：2020-07-01

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