Catalytic Reductive Aldol and Mannich Reactions of Enone, Acrylate, and Vinyl Heteroaromatic Pronucleophiles.,Chemical Reviews

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Catalytic Reductive Aldol and Mannich Reactions of Enone, Acrylate, and Vinyl Heteroaromatic Pronucleophiles.
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-03-19 , DOI: 10.1021/acs.chemrev.0c00053
Cole C Meyer ₁ , Eliezer Ortiz ₁ , Michael J Krische ₁

Affiliation

Catalytic reductive coupling of enone, acrylate, or vinyl heteroaromatic pronucleophiles with carbonyl or imine partners offers an alternative to base-mediated enolization in aldol- and Mannich-type reactions. In this review, direct catalytic reductive aldol and Mannich reactions are exhaustively catalogued on the basis of metal or organocatalyst. Stepwise processes involving enone conjugate reduction to form discrete enol or (metallo)enolate derivatives followed by introduction of carbonyl or imine electrophiles and aldol reactions initiated via enone conjugate addition are not covered.

中文翻译：

烯酮、丙烯酸酯和乙烯基杂芳族亲核试剂的催化还原羟醛和曼尼希反应。

烯酮、丙烯酸酯或乙烯基杂芳族亲核试剂与羰基或亚胺伴侣的催化还原偶联为羟醛和曼尼希型反应中碱介导的烯醇化提供了替代方案。在这篇综述中，直接催化还原羟醛反应和曼尼希反应在金属或有机催化剂的基础上进行了详尽的分类。不包括涉及烯酮缀合物还原以形成离散的烯醇或(金属)烯醇化物衍生物、随后引入羰基或亚胺亲电子试剂以及通过烯酮缀合物加成引发的羟醛反应的逐步过程。

更新日期：2020-04-23

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