As one of the fundamental requirements for cell growth and proliferation, nitrogen acquisition and utilization must be tightly regulated. Nitrogen can be generated from amino acids (AAs) and utilized for biosynthetic processes through transamination and deamination reactions. Importantly, limitations of nitrogen availability in cells can disrupt the synthesis of proteins, nucleic acids, and other important nitrogen-containing compounds. Rewiring cellular metabolism to support anabolic processes is a feature common to both cancer and proliferating immune cells. In this review, we discuss how nitrogen is utilized in biosynthetic pathways and highlight different metabolic and oncogenic programs that alter the flow of nitrogen to sustain biomass production and growth, an important emerging feature of cancer and immune cell proliferation.

中文翻译：

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癌症和免疫中的氮代谢。

作为细胞生长和增殖的基本要求之一，必须严格控制氮的获取和利用。氮可以从氨基酸（AAs）中产生，并通过转氨和脱氨反应用于生物合成过程。重要的是，细胞中氮利用率的限制会破坏蛋白质，核酸和其他重要的含氮化合物的合成。重新排列细胞代谢以支持合成代谢过程是癌症和增殖性免疫细胞的共同特征。在这篇综述中，我们讨论了如何在生物合成途径中利用氮，并重点介绍了不同的代谢和致癌程序，这些程序改变了氮的流量以维持生物量的产生和增长，这是癌症和免疫细胞增殖的重要新兴特征。