Imaging Cell Death: Focus on Early Evaluation of Tumor Response to Therapy.,Bioconjugate Chemistry

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Imaging Cell Death: Focus on Early Evaluation of Tumor Response to Therapy.
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-03-09 , DOI: 10.1021/acs.bioconjchem.0c00119
Dongjian Zhang _{1,

2} , Qiaomei Jin _{1,

2} , Cuihua Jiang _{1,

2} , Meng Gao _{1,

2} , Yicheng Ni ₃ , Jian Zhang _{1,

2}

Affiliation

Cell death plays a prominent role in the treatment of cancer, because most anticancer therapies act by the induction of cell death including apoptosis, necrosis, and other pathways of cell death. Imaging cell death helps to identify treatment responders from nonresponders and thus enables patient-tailored therapy, which will increase the likelihood of treatment response and ultimately lead to improved patient survival. By taking advantage of molecular probes that specifically target the biomarkers/biochemical processes of cell death, cell death imaging can be successfully achieved. In recent years, with the increased understanding of the molecular mechanism of cell death, a variety of well-defined biomarkers/biochemical processes of cell death have been identified. By targeting these established cell death biomarkers/biochemical processes, a set of molecular imaging probes have been developed and evaluated for early monitoring treatment response in tumors. In this review, we mainly present the recent advances in identifying useful biomarkers/biochemical processes for both apoptosis and necrosis imaging and in developing molecular imaging probes targeting these biomarkers/biochemical processes, with a focus on their application in early evaluation of tumor response to therapy.

中文翻译：

成像细胞死亡：专注于肿瘤对治疗反应的早期评估。

细胞死亡在癌症的治疗中起着重要作用，因为大多数抗癌疗法都是通过诱导细胞死亡来发挥作用，包括细胞凋亡，坏死和其他细胞死亡途径。成像细胞死亡有助于从无反应者中识别出治疗反应者，从而实现针对患者的治疗，这将增加治疗反应的可能性，并最终改善患者的生存率。通过利用专门针对细胞死亡的生物标志物/生化过程的分子探针，可以成功实现细胞死亡成像。近年来，随着对细胞死亡分子机制的认识的增强，已经确定了多种明确的细胞死亡生物标志物/生化过程。通过针对这些既定的细胞死亡生物标记/生化过程，已经开发了一套分子成像探针，并对其进行了评估，以用于早期监测肿瘤中的治疗反应。在这篇综述中，我们主要介绍为凋亡和坏死成像鉴定有用的生物标志物/生化过程以及开发针对这些生物标志物/生化过程的分子成像探针的最新进展，重点是它们在早期评估肿瘤对治疗反应中的应用。。

更新日期：2020-04-23

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