Abstract Barrier film coating is the most appropriate and widely used approach to protect solid dosages from moisture, particularly for water-sensitive drugs including herbal medicines. This study aims to produce the barrier film of a typical herbal medicine by applying an electrostatic deposition process with ultrafine powders of hydroxypropyl cellulose so as to achieve the functionality of moisture protection. The flowability of the ultrafine powders was significantly improved by adding suitable nano additives. The applied plasticizer in the coating formulation had a significant effect on the water vapor permeability of the film. Also, the electrostatic deposition efficiency were significantly affected by the charging voltage of the electrostatic gun and the plasticizer ratio. Curing time and temperature were identified as two critical parameters for barrier coating in terms of surface morphology and hygroscopicity. All the results suggested that the electrostatic deposition process is capable to produce efficient barrier film for herbal medicines.

中文翻译：

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超细粉末静电干法制备的中药材防潮膜

摘要 阻隔膜包衣是保护固体制剂免受湿气影响的最合适和广泛使用的方法，特别是对水敏感的药物，包括草药。本研究旨在通过对羟丙基纤维素的超细粉末应用静电沉积工艺制备典型草药的阻隔膜，以实现防潮功能。通过添加合适的纳米添加剂，超细粉体的流动性得到显着改善。涂料配方中应用的增塑剂对薄膜的水蒸气渗透率有显着影响。此外，静电沉积效率受静电枪充电电压和增塑剂比例的显着影响。就表面形态和吸湿性而言，固化时间和温度被确定为阻隔涂层的两个关键参数。所有结果表明静电沉积工艺能够为草药生产有效的阻隔膜。