Rapid mesoscale volumetric imaging of neural activity with synaptic resolution,Nature Methods

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Rapid mesoscale volumetric imaging of neural activity with synaptic resolution
Nature Methods ( IF 36.1 ) Pub Date : 2020-03-02 , DOI: 10.1038/s41592-020-0760-9
Rongwen Lu _{1,

2} , Yajie Liang ₁ , Guanghan Meng ₃ , Pengcheng Zhou _{4,

5,

6} , Karel Svoboda ₁ , Liam Paninski _{4,

5,

6} , Na Ji _{1,

3,

7,

8,

9}

Affiliation

Imaging neurons and neural circuits over large volumes at high speed and subcellular resolution is a difficult task. Incorporating a Bessel focus module into a two-photon fluorescence mesoscope, we achieved rapid volumetric imaging of neural activity over the mesoscale with synaptic resolution. We applied the technology to calcium imaging of entire dendritic spans of neurons as well as neural ensembles within multiple cortical regions over two hemispheres of the awake mouse brain.

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