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A Biomimetic 3D-Self-Forming Approach for Microvascular Scaffolds.
Advanced Science ( IF 14.3 ) Pub Date : 2020-03-01 , DOI: 10.1002/advs.201903553 Liucheng Zhang 1 , Yi Xiang 2 , Hongbo Zhang 3 , Liying Cheng 1 , Xiyuan Mao 1 , Ning An 4 , Lu Zhang 1 , Jinxiong Zhou 4 , Lianfu Deng 2 , Yuguang Zhang 1 , Xiaoming Sun 1 , Hélder A Santos 5, 6 , Wenguo Cui 2
Advanced Science ( IF 14.3 ) Pub Date : 2020-03-01 , DOI: 10.1002/advs.201903553 Liucheng Zhang 1 , Yi Xiang 2 , Hongbo Zhang 3 , Liying Cheng 1 , Xiyuan Mao 1 , Ning An 4 , Lu Zhang 1 , Jinxiong Zhou 4 , Lianfu Deng 2 , Yuguang Zhang 1 , Xiaoming Sun 1 , Hélder A Santos 5, 6 , Wenguo Cui 2
Affiliation
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The development of science and technology often drew lessons from natural phenomena. Herein, inspired by drying-driven curling of apple peels, hydrogel-based micro-scaled hollow tubules (MHTs) are proposed for biomimicking microvessels, which promote microcirculation and improve the survival of random skin flaps. MHTs with various pipeline structures are fabricated using hydrogel in corresponding shapes, such as Y-branches, anastomosis rings, and triangle loops. Adjustable diameters can be achieved by altering the concentration and cross-linking time of the hydrogel. Based on this rationale, biomimetic microvessels with diameters of 50-500 µm are cultivated in vitro by coculture of MHTs and human umbilical vein endothelial cells. In vivo studies show their excellent performance to promote microcirculation and improve the survival of random skin flaps. In conclusion, the present work proposes and validifies a biomimetic 3D self-forming method for the fabrication of biomimetic vessels and microvascular scaffolds with high biocompatibility and stability based on hydrogel materials, such as gelatin and hyaluronic acid.
中文翻译：
微血管支架的仿生 3D 自成型方法。
科学技术的发展常常借鉴自然现象。在此，受苹果皮干燥驱动卷曲的启发，提出了基于水凝胶的微型空心小管（MHT）用于仿生微血管，可促进微循环并提高随机皮瓣的存活率。使用水凝胶制造具有各种管道结构的MHT，其具有相应的形状，例如Y形分支、吻合环和三角环。通过改变水凝胶的浓度和交联时间可以实现可调节的直径。基于此原理，通过MHT与人脐静脉内皮细胞共培养，在体外培养出直径为50-500 µm的仿生微血管。体内研究表明它们具有促进微循环和提高随机皮瓣成活的优异性能。总之，本工作提出并验证了一种基于明胶和透明质酸等水凝胶材料的仿生3D自成型方法，用于制造具有高生物相容性和稳定性的仿生血管和微血管支架。
更新日期：2020-03-01
中文翻译：
微血管支架的仿生 3D 自成型方法。
科学技术的发展常常借鉴自然现象。在此，受苹果皮干燥驱动卷曲的启发，提出了基于水凝胶的微型空心小管（MHT）用于仿生微血管，可促进微循环并提高随机皮瓣的存活率。使用水凝胶制造具有各种管道结构的MHT，其具有相应的形状，例如Y形分支、吻合环和三角环。通过改变水凝胶的浓度和交联时间可以实现可调节的直径。基于此原理，通过MHT与人脐静脉内皮细胞共培养，在体外培养出直径为50-500 µm的仿生微血管。体内研究表明它们具有促进微循环和提高随机皮瓣成活的优异性能。总之，本工作提出并验证了一种基于明胶和透明质酸等水凝胶材料的仿生3D自成型方法，用于制造具有高生物相容性和稳定性的仿生血管和微血管支架。
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