A mild protocol for the synthesis of folate–peptide/protein conjugates targeting tryptophan residues is described. This synthetic protocol is advantageous for homogeneous conjugation of chemically sensitive folates to biomolecules, with potential applications in cancer therapy and diagnostics.

中文翻译：

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色氨酸-叶酸结合物的合成

描述了一种针对色氨酸残基合成叶酸-肽/蛋白质偶联物的温和方案。这种合成方案有利于化学敏感叶酸与生物分子的均匀结合，在癌症治疗和诊断方面具有潜在应用。