This study compared enhanced serotonin (5-HT) synthesis roles of γ-[Glu]n-Trp (EW) and whey protein hydrolysate (WPH, Val-Ala-Gly-Thr-Trp-Tyr, Val-Ala-Gly-Thr-Trp, Ser-Ala-Trp-Tyr, Trp-Tyr-Ser, Gly-Thr-Trp) using anxious depression C57BL/6 mice. As an index of serotonergic activity, we assessed 5-HT levels in response to Trp oligopeptide ingestion. The neuroprotective and hypothalamic-pituitaryadrenal (HPA) axis hormones were examined in order to characterize the suggested improvements of anxious depression observed in mice after ingestion Trp oligopeptide. The 5-HT levels were increasingly enhanced by the EW and WPH diet, with the EW being more effective. But WPH had higher capacity on anti-oxidative than EW. EW and WPH could normalize the levels of HPA axis hormones, and promote brain-derived neurotrophic factor (BDNF)/tyrosine kinase B (TrkB) signaling. In conclusion, Trp oligopeptide ingestion neuroprotective and HPA regulation effects possibly related to serotonergic activation and anti-oxidation. Consumed Trp oligopeptide diets may induce beneficial effects on anxious depression.

这项研究比较了γ增强的5-羟色胺（5-HT）合成作用-[Glu] n-Trp（EW）和乳清蛋白水解物（WPH，Val-Ala-Gly-Thr-Trp-Tyr，Val-Ala-Gly-Thr-Trp，Ser-Ala-Trp-Tyr，Trp-Tyr -Ser，Gly-Thr-Trp），使用焦虑抑郁症C57BL / 6小鼠。作为血清素能活性的指标，我们评估了响应Trp寡肽摄入的5-HT水平。检查神经保护性和下丘脑-垂体-肾上腺皮质激素（HPA）轴激素，以表征摄取Trp寡肽后在小鼠中观察到的焦虑抑郁症的改善建议。EW和WPH饮食使5-HT水平越来越高，而EW更有效。但是WPH的抗氧化能力比EW高。EW和WPH可以使HPA轴激素水平正常化，并促进脑源性神经营养因子（BDNF）/酪氨酸激酶B（TrkB）信号传导。结论，Trp寡肽摄入对神经保护和HPA的调节作用可能与血清素能激活和抗氧化有关。食用Trp寡肽饮食可能会对焦虑抑郁症产生有益的影响。