Differential effects of 11 years of long-term injectable testosterone undecanoate therapy on anthropometric and metabolic parameters in hypogonadal men with normal weight, overweight and obesity in comparison with untreated controls: real-world data from a controlled registry study.,International Journal of Obesity

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Differential effects of 11 years of long-term injectable testosterone undecanoate therapy on anthropometric and metabolic parameters in hypogonadal men with normal weight, overweight and obesity in comparison with untreated controls: real-world data from a controlled registry study.
International Journal of Obesity ( IF 4.2 ) Pub Date : 2020-01-28 , DOI: 10.1038/s41366-019-0517-7
F Saad _{1,

2} , G Doros ₃ , K S Haider ₄ , A Haider ₄

Affiliation

BACKGROUND AND SIGNIFICANCE Obesity is a chronic disease, warranting long-term medical intervention. We evaluated effects of testosterone (T) therapy (Th) in men with T deficiency with normal weight, overweight and obesity on anthropometric and metabolic parameters, compared with untreated men. METHODS Hypogonadal men (n = 823) with total T ≤ 12.1 nmol/L (age: 60.6 ± 7.0 years) participated in an ongoing registry study. Among these men 474 (57.6%) were obese, 286 (34.8%) overweight and 63 (7.7%) had normal weight. T undecanoate injections were administered to 428 men and 395 remained untreated. Anthropometric and metabolic parameters were measured at least twice a year and changes adjusted for confounding factors to account for baseline differences between groups. RESULTS Long-term TTh in hypogonadal men, irrespective of weight at baseline, produced improvements in body weight, waist circumference (WC) and body mass index (BMI). Furthermore, TTh decreased fasting blood glucose and HbA1c and improved lipid profiles. Gradual decreases in blood pressure (systolic and diastolic) and pulse pressure occurred in men treated with T in each group. Marked reductions in mortality and major cardiovascular events were recorded in men receiving TTh. CONCLUSIONS Our findings demonstrate that TTh produces reductions in weight, WC, and BMI. There were 77 (19.5%) deaths in the untreated groups and 23 (5.4%) in the T-groups. Based on these findings we suggest that long-term TTh in overweight and obese hypogonadal men produces progressive and sustained clinically meaningful weight loss and that TTh may contribute to reductions in mortality and incident major adverse cardiovascular events.

中文翻译：

与未治疗的对照组相比，11 年的长期注射十一酸睾酮对正常体重、超重和肥胖的性腺功能减退男性人体测量学和代谢参数的不同影响：来自对照注册研究的真实世界数据。

背景和意义肥胖是一种慢性疾病，需要长期的医疗干预。与未接受治疗的男性相比，我们评估了睾酮 (T) 疗法 (Th) 在正常体重、超重和肥胖的男性中对人体测量学和代谢参数的影响。方法总 T ≤ 12.1 nmol/L（年龄：60.6 ± 7.0 岁）的性腺功能减退男性（n = 823）参加了一项正在进行的注册研究。在这些男性中，474 人 (57.6%) 肥胖，286 人 (34.8%) 超重，63 人 (7.7%) 体重正常。对 428 名男性进行了十一酸甘油酯注射，其中 395 人未接受治疗。人体测量学和代谢参数每年至少测量两次，并根据混杂因素调整变化以解释各组之间的基线差异。结果性腺功能减退男性的长期 TTh，无论基线体重如何，导致体重、腰围 (WC) 和体重指数 (BMI) 的改善。此外，TTh 可降低空腹血糖和 HbA1c，并改善血脂状况。每组接受 T 治疗的男性的血压（收缩压和舒张压）和脉压逐渐降低。在接受 TTh 治疗的男性中，死亡率和主要心血管事件显着降低。结论我们的研究结果表明，TTh 可降低体重、WC 和 BMI。未治疗组中有 77 人 (19.5%) 死亡，T 组中有 23 人 (5.4%) 死亡。基于这些发现，我们建议超重和肥胖性腺功能减退男性的长期 TTh 会产生渐进性和持续的有临床意义的体重减轻，并且 TTh 可能有助于降低死亡率和主要不良心血管事件的发生率。

更新日期：2020-01-28

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