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Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories.
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2020-02-10 , DOI: 10.1038/s41583-019-0260-z Thomas Hainmueller 1, 2, 3, 4 , Marlene Bartos 1
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2020-02-10 , DOI: 10.1038/s41583-019-0260-z Thomas Hainmueller 1, 2, 3, 4 , Marlene Bartos 1
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The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating that the rest of the hippocampus (CA1-CA3) can operate autonomously under certain conditions. An extensive body of theoretical work has proposed how the architectural elements and various cell types of the DG may underlie its function in cognition. Recent studies recorded and manipulated the activity of different neuron types in the DG during memory tasks and have provided exciting new insights into the mechanisms of DG computational processes, particularly for the encoding, retrieval and discrimination of similar memories. Here, we review these DG-dependent mnemonic functions in light of the new findings and explore mechanistic links between the cellular and network properties of, and the computations performed by, the DG.
中文翻译：
齿状回电路，用于对情景记忆进行编码，检索和区分。
齿状回（DG）在海马记忆形成中起关键作用。有趣的是，DG损害会损害许多但并非全部损害海马依赖的记忆功能，这表明海马的其余部分（CA1-CA3）在一定条件下可以自主运行。大量的理论工作提出了DG的结构元素和各种细胞类型如何可能是其认知功能的基础。最近的研究记录和操纵了DG在记忆任务期间不同神经元类型的活动，并为DG计算过程的机制提供了令人振奋的新见解，特别是对于类似记忆的编码，检索和区分。这里，
更新日期：2020-02-10
中文翻译：
齿状回电路，用于对情景记忆进行编码，检索和区分。
齿状回（DG）在海马记忆形成中起关键作用。有趣的是，DG损害会损害许多但并非全部损害海马依赖的记忆功能，这表明海马的其余部分（CA1-CA3）在一定条件下可以自主运行。大量的理论工作提出了DG的结构元素和各种细胞类型如何可能是其认知功能的基础。最近的研究记录和操纵了DG在记忆任务期间不同神经元类型的活动，并为DG计算过程的机制提供了令人振奋的新见解，特别是对于类似记忆的编码，检索和区分。这里，
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