Ischaemic priapism (IP) is a urological emergency that can lead to permanent erectile dysfunction (ED) and penile deformity if not promptly managed. Refractory ischaemic priapism (RIP), defined as IP persisting beyond 48 hours despite conventional interventions, necessitates a paradigm shift in treatment strategy. Early penile prosthesis (PP) implantation offers a proactive approach in surgical management

The Orgasm Rating Scale (ORS) evaluates the subjective orgasm experience (SOE), both in the context of sexual relationships and solitary masturbation. It has been validated in Spain, but to examine the construct in different cultures, this study aimed to analyze its psychometric properties in the Colombian population. A total of 1 097 adults aged 18 to 62 years (mean 27.92 ± 8.54) responded to the

Nearly half of the women reaching menopause in the United States (US) experience changes to reproductive health and quality of life. Vaginal estrogen is a widely recognized treatment option for menopausal symptoms. Our study aims to investigate public interest through Google search trends and its comparative prevalence in medical literature for postmenopausal women. A retrospective analysis of Google

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful lesions primarily in apocrine gland-bearing regions, with scrotal involvement in 6% of male patients. Despite its notable prevalence, particularly in Western countries, HS remains frequently under-reported, leading to delays in diagnosis and treatment that exacerbate disease prognosis and significantly diminish

Penile augmentation procedures are controversial, primarily because most men seeking these interventions have penile dimensions within the normal range, and due to the associated risks of severe complications. This narrative review explores the effects of foreign body implantations and injections in the penis. Retrospective case series reveal the use of unapproved oil-based substances injected in non-sterile

Hematoma formation is one of the complications of inflatable penile prosthesis implantation (iPP), possibly indicating surgical evacuation, or resulting in infection and removal of the implant. Gelatin Sponge (Gelfoam®, Pfizer, USA) is sterile compressed sponge, used as a hemostatic agent, directly applied to bleeding surfaces. It is water insoluble, but absorbable within 4–6 weeks with minimal scar

This single-institution, pre- post-intervention, retrospective study (2019-2021) compared the effect of dorsal penile nerve and ring block of 20 cc bupivacaine (0.25%) with and without dexmedetomidine (70 µg) + dexamethasone (4 mg) on pain scores, and both intra- and postoperative analgesia after primary inflatable penile prosthesis implantation. Dorsal penile nerve and ring block were completed with

Fungal infections after inflatable penile prosthesis (IPP) surgery are uncommon but clinically significant due to their association with prosthesis loss and reoperation. While antifungal prophylaxis has been proposed as a preventive strategy, supporting evidence remains limited and inconsistent. At our institution, perioperative antifungal agents have never been part of the IPP protocol. Among 1772

TGF-β1 plays a fundamental role in the pathogenesis of Peyronie's disease, driving the excessive extracellular matrix accumulation and fibroblast activation characteristic of fibrosis. As in many fibrotic disorders, its action via Smad transcription factors presents a key therapeutic target. Given the notable deficiency in proven effective conservative treatments for Peyronie's disease, particularly

Humans have long used various substances to enhance sexual pleasure and performance, often at the expense of their overall health. This review investigates the sexual-related effects of recreational drugs, including amphetamines, 3,4-methylenedioxymethamphetamine (MDMA), mephedrone, gamma-hydroxybutyrate (GHB), and ketamine. By examining anecdotal evidence, self-reports, and limited scientific data

The diagnosis of female genital cutting/mutilation (FGC/M) in children is complex, as findings may be subtle or mimic normal vulval variation. England and Wales safeguarding guidance advises referral of any signs of FGC/M, regardless of the observer’s background. We hypothesised that most children referred to a specialist clinic for concerns about vulval appearance would not have undergone FGC/M, reflecting

Post-vasectomy pain syndrome (PVPS) is a chronic and potentially debilitating condition affecting a subset of men undergoing vasectomy. Despite its impact on quality of life, PVPS remains underrecognized, and management strategies are often inconsistent due to limited high-quality evidence. This review aims to synthesize current evidence on the prevention, diagnosis, and management of PVPS and to provide

Recent studies have explored peripheral electrical stimulation (pES) as a potential treatment for erectile dysfunction (ED). This systematic review and meta-analysis evaluate the efficacy of pES in ED patients. A systematic search was conducted across PubMed, Scopus, ScienceDirect, and Web of Science to identify randomized controlled trials (RCTs) published between 2015 and 2025. Studies comparing

Hypoactive Sexual Desire Dysfunction (HSDD) in women has a complex origin, and addressing modifiable factors can lead to the best outcomes. One contributing factor is sexual boredom, particularly in women in monogamous relationships and we decided to evaluate sexual novelty as a therapeutic strategy in such women using prospective randomized study design. These women were recruited following screening

Delayed ejaculation (DE) and anejaculation (AE) pose significant clinical challenges in andrology and sexual medicine, with no universally effective or standardized treatments currently available. In clinical practice, management strategies are primarily empirical. Drawing inspiration from the physiological mechanisms underlying nocturnal emissions, we propose a novel therapeutic approach for non-organic

Surgical site infections remain a devastating complication of inflatable penile prosthesis (IPP) implantation. We evaluated a novel surgical protocol combining chlorhexidine-alcohol skin preparation with fibrin sealant-mediated hemostasis and no drain placement, hypothesizing that it would reduce infection and hematoma rates. Between January 2020 and December 2023, 103 men underwent primary IPP placement

Hyaluronic acid (HA) fillers are widely used in aesthetic medicine due to their biocompatibility and reversibility with hyaluronidase. However, their use in penile augmentation (PA) remains limited, and knowledge of hyaluronidase application in this context is sparse. This case series presents four patients with residual HA from previous penile girth enhancement (PGE), successfully managed using hyaluronidase

Recurrent ischemic priapism is a common complication in males with sickle cell disease (SCD), strongly associated with chronic intravascular hemolysis. Hemolysis elevates circulating free heme levels, which are metabolized by heme oxygenase (HO) into carbon monoxide (CO). CO activates soluble guanylate cyclase (sGC), increasing cyclic GMP (cGMP) and promoting smooth muscle relaxation. This study hypothesizes

This study aimed to evaluate the reliability, readability, and understandability of chatbot responses to frequently asked questions about premature ejaculation, and to assess the contributions, potential risks, and limitations of artificial intelligence. Fifteen questions were selected using data from Google Trends and posed to the chatbots Copilot, Gemini, ChatGPT4o, ChatGPT4oPlus, and DeepSeek-R1

Penile enlargement procedures have become increasingly popular for aesthetic and psychological reasons. While traditional enlargement techniques, such as fat grafting, hyaluronic acid fillers, and silicone implants, have varying degrees of success, they also present risks such as infection, migration, and resorption. The Hardrock Sandwich Technique (HST) combines bovine pericardial grafts with autologous

The artificial urinary sphincter is the standard surgical treatment for persistent stress urinary incontinence in male patients when conservative methods fail, with the perineal approach being the most commonly used. However, the penoscrotal approach, which requires only a single incision, offers advantages such as shorter operation times and ease of execution, though concerns about lower dry rates

Paraffinoma of the penis is a rare but potentially debilitating consequence of subcutaneous mineral-oil injection for penile enlargement. We report a 34-year-old male who presented after failed urethral catheterization with diffuse penile induration and pain during intercourse, following self-injection of paraffin into the preputial region. Clinical assessment and penile ultrasound with color Doppler

Vasectomy is a highly effective method of permanent contraception for men, offering a minimally invasive and cost-efficient alternative to female sterilization. Over 500,000 vasectomies are performed annually in the U.S., making it the most common non-diagnostic procedure conducted by urologists. Despite this, many residents may not gain adequate training in performing vasectomies in residency, and

Phalloplasty following penectomy for penile cancer presents a complex reconstructive challenge, requiring restoration of urinary and sexual function while addressing anatomical and psychological sequelae. Unlike gender-affirming phalloplasty, this procedure is complicated by previous surgery and potential anatomical deficits. However, limited data exist to guide reconstruction in this cohort. This

Xu et al. [1] present a novel and timely analysis linking preoperative depression and anxiety to an increased risk of complications following inflatable penile prosthesis (IPP) surgery. Their retrospective cohort study, encompassing 279 IPP procedures performed by a single surgeon, is the first in our field to explore the influence of mental health on postoperative outcomes systematically. Their findings

The comprehensive review by Tsampoukas et al., outlines a concerning reality in contemporary andrology: the absence of consensus regarding the definition of testosterone deficiency (TD) and male hypogonadism diagnosis/management [1]. Their analysis of nine major guidelines reveals discrepancies that extend beyond mere threshold differences, potentially affecting clinical decision-making. These variations

Curran and Love deliver what the literature has long needed: a roadmap for managing one of the rarest but most frustrating complications in prosthetic urology, reservoir migration. Their systematic review combines data from 35 studies and over 5,700 patients, providing a pragmatic clinical algorithm grounded in risk stratification [1].Let’s be clear, migration is rare. But in patients with prior pelvic

We thank the authors for their thoughtful commentary and for contributing to the ongoing discussion regarding the use of intralesional collagenase clostridium histolyticum (CCH) in patients with Peyronie’s disease (PD) during the acute phase [1]. We greatly appreciate their thorough analysis and insights, which align with the findings presented in our study. In summary, the authors advocate for a more