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Effect of ultrasonic power on delivery of quercetin in emulsions stabilized using octenyl succinic anhydride (OSA) modified broken japonica rice starch Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-14 Xue Wang, Ning Wang, Dandan Wu, Liqi Wang, Na Zhang, Dianyu Yu
In this study, emulsions stabilized by octenyl succinic anhydride-modified broken japonica rice starch (OSA-BJRS) were prepared at different ultrasonic power intensities for the delivery, controlled release, and improved bioavailability of quercetin. The OSA-BJRS emulsions ultrasonicated at 400 W exhibited the highest encapsulation efficiency (89.37 %) and loading efficiency (58.34 %) of quercetin
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Corrigendum to “Effect of glutaraldehyde and calcium chloride as different crosslinking agents on the characteristics of chitosan/cellulose nanocrystals scaffold” [Int. J. Biol. Macromol. 208 (2022) 912–924] Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-13 Fatemeh Doustdar, Ali Olad, Marjan Ghorbani
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Hydrophobic substrate binding pocket remodeling of echinocandin B deacylase based on multi-dimensional rational design Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-11 Heng Tang, Han-yue Zhu, Yin-feng Huang, Ze-yu Wu, Shu-ping Zou, Zhi-qiang Liu, Yu-guo Zheng
deacylase (AAC)-catalyzed deacylation of echinocandin B (ECB) is a promising method for the synthesis of anidulafungin, the newest of the echinocandin antifungal agents. However, the low activity of AAC significantly limits its practical application. In this work, we have devised a multi-dimensional rational design strategy for AAC, conducting separate analyses on the substrate-binding pocket's volume
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Design and fabrication of functionalized curdlan-curcumin delivery system to facilitate the therapeutic effects of curcumin on breast cancer Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-11 Showkat Ali Ganie, Rayees Ahmad Naik, Ovas Ahmad Dar, Luqman Jameel Rather, Mohammed A. Assiri, Qing Li
We developed a facile method for the fabrication of a biodegradable delivery system composed of two blocks: curdlan and curcumin. This was achieved by chemical functionalization of curdlan through tosylation, amination followed by complexation with curcumin. A comprehensive evaluation of structural characterization and component stability showed that cur-cum complex exhibited better anticancer properties
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Corrigendum to “Water-soluble chlorin e6-hydroxypropyl chitosan as a high-efficiency photoantimicrobial agent against Staphylococcus aureus” [Int. J. Biol. Macromol. 208 (31 May 2022) 669–677] Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-11 Lin Yue, Meihong Zheng, Min Wang, Imran Mahmood Khan, Xiaowei Ding, Yin Zhang, Zhouping Wang
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Effect of synergistic fermentation of Saccharomyces cerevisiae and Lactobacillus plantarum on thermal properties of hyaluronic acid-wheat starch system Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-10 Zhen Wang, Sijie Zhang, Huiping Wang, Jihong Huang, Luyang Wang
Hyaluronic acid (HA), as a multifunctional hydrophilic polysaccharide, is potentially beneficial in improving the thermal stability of fermented modified starches, but relevant insights at the molecular level are lacking. The aim of this study was to investigate the effect of different levels (0 %, 3 %, 6 %, 9 %, 12 % and 15 %) of HA on the structural, thermal and pasting properties of wheat starch
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Extraction of lignin-containing nanocellulose fibrils from date palm waste using a green solvent Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-10 Mohsin Raza, Mohammad Jawaid, Basim Abu-Jdayil
Lignin-containing nanocellulose (LNC) is a compelling alternative to traditional nanocellulose (NC), it offers enhanced yields and a reduction in the demand for toxic chemicals. This research involves the isolation of LNC from date palm waste using a green hydrolysis process and its subsequent characterization. The potential of using ionic liquids (ILs) as green solvents to isolate LNC has not yet
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Exploring FGFR signaling inhibition as a promising approach in breast cancer treatment Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-10 Yan Peng, Pengfei Zhang, Wuxuan Mei, Changchun Zeng
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BdTTLL3B-mediated polyglycylation is involved in the spermatogenesis in Bactrocera dorsalis Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-10 Shunjiao Wu, Lilin Ran, Tongfang Zhang, Ying Li, Yonghong Xu, Yaying Li, Huai Liu, Jia Wang
Polyglycylation is a post-translational modification that generates glycine side chains in the C-terminal domains of both α- and β-tubulins. To date, the patterns and significance of polyglycylation across insect species remain largely unknown. The TTLL3B was thought to be a polyglycylase and be essential for polyglycylation in dipteran insects. In this study, the of () was identified and characterized
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Molecular characterization of vascular endothelial growth factor b from spotted sea bass (Lateolabrax maculatus) and its potential roles in decreasing lipid deposition Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-10 Ningning Su, Jun Zheng, Guanrong Zhang, Junfeng Guan, Xin Gao, Zhiyi Cheng, Chao Xu, Dizhi Xie, Yuanyou Li
Vascular endothelial growth factor B (VEGFB), a member of the VEGF family, exhibits limited angiogenic activity in mammals but plays an unexpected role in targeting lipids to peripheral tissues. However, its role in lipid metabolism in fish is unknown. In this study, the gene was cloned and characterized from spotted sea bass (). It encodes 254 amino acids and possesses the typical characteristics
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Semisynthesis of new sulfated heterorhamnan derivatives obtained from green seaweed Gayralia brasiliensis and evaluation of their anticoagulant activity Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-10 Danielly Caetano, Lauri Alves Junior, Jaqueline Carneiro, Diogo R.B. Ducatti, Alan Guilherme Gonçalves, Miguel D. Noseda, Maria Eugênia R. Duarte
Marine green algae produce sulfated polysaccharides with diverse structures and a wide range of biological activities. This study aimed to enhance the biotechnological potential of sulfated heterorhamnan (Gb1) from by chemically modifying it for improved or new biological functions. Using controlled Smith Degradation (GBS) and -alkylation with 3-chloropropylamine, we synthesized partially water-soluble
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Corrigendum to “Preparation and characterization of electrospun nanofibers-based facial mask containing hyaluronic acid as a moisturizing component and huangshui polysaccharide as an antioxidant component” [International Journal of Biological Macromolecules volume 214, 1 August 2022, pages 212–219] Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-10 Hualei Xu, Ziyan Wu, Dan Zhao, Haiyan Liang, Huanxiang Yuan, Changtao Wang
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Engineered protein cages with enhanced extracellular drug release for elevated antitumor efficacy Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-09 Wen Yan, Hanlin Li, Jiamin Ning, Shuhao Huang, Longguang Jiang, Peng Xu, Mingdong Huang, Cai Yuan
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A new paradigm for smart packaging: A dual-channel freshness monitoring platform based on aerogels of sodium alginate-anthocyanin complex with high colorimetric sensitivity and stability Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-09 Shiwei Zheng, Dangfeng Wang, Likun Ren, Tian Wang, Yuqiong Meng, Rui Ma, Shulin Wang, Fangchao Cui, Tingting Li, Jianrong Li
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In vitro digestion properties of Laiyang pear residue polysaccharides and it counteracts DSS-induced gut injury in mice via modulating gut inflammation, gut microbiota and intestinal barrier Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-09 Liqing Fan, Xiangyang Zhu, Dexi Zhang, Dapeng Li, Chen Zhang
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Biophysical insight into the binding mechanism of epigallocatechin-3-gallate and cholecalciferol to albumin and its preventive effect against AGEs formation: An in vitro and in silico approach Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-09 Sana Siddiqui, Rizwan Ahmad, Yusra Ahmad, Abul Faiz Faizy, Shagufta Moin
Advanced glycation end products (AGEs) are produced non-enzymatically through the process of glycation. Increased AGEs production has been linked to several diseases including polycystic ovary syndrome (PCOS). PCOS contributes to the development of secondary comorbidities, such as diabetes, cardiovascular complications, infertility, etc. Consequently, research is going on AGEs-inhibiting phytochemicals
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Efficient isomerization of glucose into fructose by MgO-doped lignin-derived ordered mesoporous carbon Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-09 Zhibin Han, Xiaoqi Wang, Xiaolan Zhao, Feng Shen, Boxiong Shen, Xinhua Qi
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Hot air–assisted radio frequency drying of corn kernels: the effect on structure and functionality properties of corn starch Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-09 Liuyang Ren, Zhaohui Zheng, Hanyu Fu, Pei Yang, Jingshen Xu, Deyong Yang
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Simultaneously efficient dissolution and structural modification of chrysanthemum pectin: Targeting at proliferation of Bacteroides Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-09 Wenying Wang, Lianzhu Lin, Mouming Zhao
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MFTrans: A multi-feature transformer network for protein secondary structure prediction Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-09 Yifu Chen, Guanxing Chen, Calvin Yu-Chian Chen
In the rapidly evolving field of computational biology, accurate prediction of protein secondary structures is crucial for understanding protein functions, facilitating drug discovery, and advancing disease diagnostics. In this paper, we propose MFTrans, a deep learning-based multi-feature fusion network aimed at enhancing the precision and efficiency of Protein Secondary Structure Prediction (PSSP)
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Postbiotics-enriched flaxseed mucilage coating: A solution to improving postharvest quality and shelf life of strawberry Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-09 Houshmand Sharafi, Abolfazl Alirezalu, Shao-Quan Liu, Azad Karami, Mehran Moradi
This research aimed to assess the effects of flaxseed mucilage (Mu) coatings supplemented with postbiotics (P) obtained from LA-5 on various physical, biochemical, and microbial characteristics of strawberry fruits. Strawberry fruits were immersed for 2 min in Mu (2.5 % mucilage in distilled water), Mu (5 % mucilage in distilled water), P-Mu (2.5 % mucilage in undiluted postbiotics) and P-Mu (5 % mucilage
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Characterization of O/W emulgels based on whey protein-alginate-inulin coacervates: Influence of temperature and ultrasound as protein preconditioning process Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-09 Anthony M. Ortiz-Deleón, Angélica Román-Guerrero, Ofelia Sandoval-Castilla, Juan Carlos Cuevas-Bernardino
Preconditioning processes in proteins play a crucial role in enhancing their functional properties as surface active agents. Whey protein isolate (WPI, 20 wt%) was preconditioned via temperature (WPI, 90 °C) or ultrasound (WPI, 20 kHz, 80 % amplitude). FTIR and zeta potential analysis demonstrated the effect of the preconditioning process on the secondary structure and surface properties of WPI. WPI-Alginate:Inulin
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Interpenetrating nanofibrillar membrane of self-assembled collagen and antimicrobial peptides for enhanced bone regeneration Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-08 Jinhong Dai, Nicholas G. Fischer, Joseph R. Rahimi, Hongning Wang, Chaoming Hu, Wener Chen, Yifan Lin, Ting Sang, Hooi Pin Chew, Liang Kong, Conrado Aparicio, Zhou Ye, Shengbin Huang
Bone regeneration remains a major clinical challenge, especially when infection necessitates prolonged antibiotic treatment. This study presents a membrane composed of self-assembled and interpenetrating GL13K, an antimicrobial peptide (AMP) derived from a salivary protein, in a collagen membrane for antimicrobial activity and enhanced bone regeneration. Commercially available collagen membranes were
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Improved antioxidant activity of pretreated lignin nanoparticles: Evaluation and self-assembly Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-08 Mingfu Li, Yingchuan Zhang, Hongli Ma, Qida Peng, Douyong Min, Pingjun Zhang, Liqun Jiang
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Study of the changes on the physicochemical properties of isolated lentil starch during germination Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-08 Juan Carlos Lucas-Aguirre, Victor Dumar Quintero-Castaño, Melissa Beltrán-Bueno, Mario Enrique Rodríguez-García
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Research progress and future development potential of Flammulina velutipes polysaccharides in the preparation process, structure analysis, biology, and pharmacology: A review Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-08 Shiying Ye, Yi Gao, Xiangyan Hu, Jiye Cai, Shaowei Sun, Jinhuan Jiang
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Opportunity for a greener recovery of dysprosium(III) from secondary sources by a novel Mannich reaction-modified phosphorylated chitosan hydrogel Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-08 John Rey Apostol Romal, Say Kee Ong
The depleting supply of natural sources of rare earth elements (REE) is a concern to many nations as demand for advanced technology is becoming vital for national security. In this communication, the recovery of dysprosium(III) from aqueous systems was exemplified by a modified phosphorylated chitosan (PCs/MB) prepared by the C-Mannich reaction of phosphorylated chitosan, glutaraldehyde, and 4-hydroxycoumarin
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Corrigendum to “In-situ visualizing selective lignin dissolution of tracheids wall in reaction wood” [Int. J. Biol. Macromol. 222 (Part A) (1 December 2022) 691–700] Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-08 Linxin Dai, Jiajun Wang, Xing-E Liu, Qianli Ma, Benhua Fei, Jianfeng Ma, Zhi Jin
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Contribution of the transcription factor SfGATAe to Bt Cry toxin resistance in Spodoptera frugiperda through reduction of ABCC2 expression Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-07 Leilei Liu, Wenfeng He, Peiwen Xu, Wei Wei, Jintao Wang, Kaiyu Liu
Insect resistance evolution poses a significant threat to the advantages of biopesticides and transgenic crops utilizing insecticidal Cry-toxins from (Bt). However, there is limited research on the relationship between transcriptional regulation of specific toxin receptors in lepidopteran insects and their resistance to Bt toxins. Here, we report the positive regulatory role of the SfGATAe transcription
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A facile cellulose finishing strategy through in-situ growth of sliver-doped manganese dioxide assisted by amine-quinone for improving indoor living quality Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-07 Xueming Bao, Biaobiao Yan, Yuanyuan Yu, Bo Xu, Li Cui, Man Zhou, Qiang Wang, Ping Wang
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Assessing the structural stability and drug encapsulation efficiency of poly(ethylene glycol)-poly(L-lactic acid) nanoparticles loaded with atorvastatin calcium: Based on dissipative particle dynamics Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-07 Yun Hao Feng, Wei Xin Guo, Zhuo Lin Li, Liu Fu Hu, Yue Liu, Li Yue Jing, Jianhao Wang, Mohammad-Ali Shahbazi, Bo Zhi Chen, Xin Dong Guo
Block polymer micelles have been proven highly biocompatible and effective in improving drug utilization for delivering atorvastatin calcium. Therefore, it is of great significance to measure the stability of drug-loading nano micelles from the perspective of block polymer molecular sequence design, which would provide theoretical guidance for subsequent clinical applications. This study aims to investigate
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Hydrothermal processing of Sarcopeltis skottsbergii and study of the potential of its carrageenan for tissue engineering Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-07 Milena Álvarez-Viñas, Fernanda Zamboni, María Dolores Torres, Maurice N. Collins, Herminia Domínguez
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Polysaccharides from Polygonatum kingianum Collett & Hemsl ameliorated fatigue by regulating NRF2/HO-1/NQO1 and AMPK/PGC-1α/TFAM signaling pathways, and gut microbiota Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-07 Xingrui Xu, Meimei Shan, Chuanqi Chu, Shenke Bie, He Wang, Shengbao Cai
Coll & Hemsl is an important Chinese medicine used for enhancing physical function and anti-fatigue, and polysaccharides (PKPs) are considered as the main bioactive components. However, the mechanisms through which PKPs exert their anti-fatigue effects are not fully understood. This study aimed more comprehensively to explore the anti-fatigue mechanisms of PKPs, focusing on metabolism, protein expression
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Identification of histidine residues that affect the T/R-state conformations of human hemoglobin using constant pH molecular dynamics simulations Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Shin-ichi Fujiwara, Kotaro Nishimura, Kazuto Imamura, Takashi Amisaki
Human hemoglobin (Hb) is a tetrameric protein consisting of two α and two β subunits that can adopt a low-affinity T- and high-affinity R-state conformations. Under physiological pH conditions, histidine (His) residues are the main sites for proton binding or release, and their protonation states can affect the T/R-state conformation of Hb. However, it remains unclear which His residues can effectively
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Order wrapped in chaos: On the roles of intrinsically disordered proteins and RNAs in the arrangement of the mitochondrial enzymatic machines Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Semen V. Nesterov, Nikolay S. Ilyinsky, Konstantin S. Plokhikh, Vladimir D. Manuylov, Yuriy M. Chesnokov, Raif G. Vasilov, Irina M. Kuznetsova, Konstantin K. Turoverov, Valentin I. Gordeliy, Alexander V. Fonin, Vladimir N. Uversky
The analysis of cryo-electron tomography images of human and rat mitochondria revealed that the mitochondrial matrix is at least as crowded as the cytosol. To mitigate the crowding effects, metabolite transport in the mitochondria primarily occurs through the intermembrane space, which is significantly less crowded. The scientific literature largely ignores how enzyme systems and metabolite transport
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Genome-wide identification, expression analysis, and abiotic stress response of the CBL and CIPK gene families in Artocarpus nanchuanensis Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Changying Xia, Xiao Zhang, Youwei Zuo, Xiaoxia Zhang, Huan Zhang, Binru Wang, Hongping Deng
, the northernmost species in the jackfruit genus, has great economic and horticultural value due to its nutritious fruit and beautiful tree shape. Calcineurin B-like proteins (CBLs) act as plant-specific Ca sensors and participate in regulating plant responses to various abiotic stresses by interacting with CBL-interacting protein kinases (CIPKs). However, the characteristics and functions of the
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Inhibition of ESCRT-independent extracellular vesicles biogenesis suppresses enterovirus 71 replication and pathogenesis in mice Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Yicong Liang, Yue Kong, Menglan Rao, Xing Zhou, Chengcheng Li, Yi Meng, Yanxi Chen, Hongjian Li, Zhen Luo
Enterovirus 71 (EV71) causes hand-foot-and-mouth disease (HFMD), neurological complications, and even fatalities in infants. Clinically, the increase of extracellular vesicles (EVs) in EV71 patients' serum was highly associated with the severity of HFMD. EV71 boosts EVs biogenesis in an endosomal sorting complex required for transport (ESCRT)-dependent manner to facilitate viral replication. Yet, the
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Anisotropic composite aerogel with thermal insulation and flame retardancy from cellulose nanofibers, calcium alginate and boric acid Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Jintao Zhu, Yangyang Wang, Xiaoyi Zhao, Nan Li, Xiaoyun Guo, Liang Zhao, Yuanyuan Yin
With the increasing severity of energy shortages and environmental pollution, there is an urgent need for advanced thermal insulation materials with excellent comprehensive performance, including low thermal conductivity, high flame resistance, and strong compressive strength. Herein, an anisotropic composite aerogel based on cellulose nanofibers (CNF), calcium alginate (CA), and boric acid (BA) is
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Preparation and sustained release of diatomite incorporated and Eudragit L100 coated hydroxypropyl cellulose/chitosan aerogel microspheres Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Yanan Sang, Jie Gao, Xiaobing Han, Tian Liang, Tao Chen, Yuan Zhao
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In situ carbothermal synthesis of carbonized bacterial cellulose embedded with nano zero-valent iron for removal of Cr(VI) Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Bo Ma, Yan Wang, Jianguo Zhu, Dan Liu, Chuntao Chen, Bianjing Sun
Carbonized bacterial cellulose embedded with highly dispersed nano zero-valent iron (nZVI), denoted as nZVI@CBC, was prepared through one-step in situ carbothermal treatment of bacterial cellulose adsorbing iron(III) nitrate. The structure characteristics of nZVI@CBC and its performance in removing hexavalent chromium Cr(VI) were investigated. Results showed the formation of nZVI@CBC with a surface
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Cellulose separation from ramie bone by one step process with green hydrogen peroxide-citric acid Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Yuyang Wu, Chunxu Luo, Liqiong Li, Yixuan Jiang, Jinhan Yu, Tianjiao Wang, Jiarun Lu, Xinwang Cao, Wei Ke, Shengyu Li
Ramie bone (RB), an agricultural waste generated in the textile industry, is a vastly productive renewable natural resource with the potential to be used as a source of cellulose. In this study, ramie bone cellulose (RB-CE) was obtained in one step using a simple and ecologically friendly hydrogen peroxide-citric acid (HPCA) treatment procedure that avoided the use of halogenated reagents and strong
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Fabrication of multifunctional facial masks from phenolic acid grafted chitosan/collagen peptides via aqueous electrospinning Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Wenfeng Hu, Haofei Yin, Yujie Guo, Yantao Gao, Yi Zhao
Facial masks have become ubiquitous in our daily life to endow skin enough moisture and activated nutrition through mask nonwovens infused with skincare ingredients. However, the active nutrients in wet masks are prone to deterioration and deactivation. Herein, a novel multifunctional nanofiber dry mask was successfully prepared using aqueous-electrospun phenolic acid grafted chitosan/collagen peptides
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Electrospraying and electrospinning of tannic acid-loaded zein: Characterization and antioxidant effects in astrocyte culture exposed to E. coli lipopolysaccharide Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Karina Pereira Luduvico, Marjana Radünz, Helen Cristina dos Santos Hackbart, Natália Pontes Bona, Nathalia Stark Pedra, Maria Rosa Chitolina, Elessandra da Rosa Zavareze, Roselia Maria Spanevello, Francieli Moro Stefanello
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Facile crosslinking methods for water-durable oven-dried cellulose nanofibril foams and their application as dye adsorbents Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Shin Young Park, Heenae Shin, Hye Jung Youn
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Isolation and characterization of exopolysaccharides from kombucha samples of different origins Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-06 Verena Hassler, Nele Brand, Daniel Wefers
Kombucha is prepared by fermenting sugared green or black tea with a symbiotic culture of bacteria and yeast (SCOBY). Some of the bacteria within the SCOBY are known to form exopolysaccharides (EPS) from sucrose. However, it is yet unknown whether water-soluble EPS are formed in kombucha, and if so, which specific EPS are present. Therefore, different kombucha samples were prepared by fermentation
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An oral bioactive chitosan-decorated doxorubicin nanoparticles/bacteria bioconjugates enhance chemotherapy efficacy in an in-situ breast cancer model Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-05 Jianmei Li, Qian Wen, Jie Dai, Biqiong Wang, Yun Lu, Zhouxue Wu, Yu Fan, Fancai Zeng, Yue Chen, Yan Zhang, Renjin Chen, Shaozhi Fu
Breast cancer is the second leading cause of cancer-related deaths among women worldwide. Despite significant advancements in chemotherapy, its effectiveness is often limited by poor drug distribution and systemic toxicity caused by the weak targeting ability of conventional therapeutic agents. The hypoxic tumor microenvironment (TME) also plays a vital role in treatment outcomes. Oral anticancer therapeutic
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Review: N1-methyl-pseudouridine (m1Ψ): Friend or foe of cancer? Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-05 Alberto Rubio-Casillas, David Cowley, Mikolaj Raszek, Vladimir N. Uversky, Elrashdy M. Redwan
Due to the health emergency created by SARS-CoV-2, the virus that causes the COVID-19 disease, the rapid implementation of a new vaccine technology was necessary. mRNA vaccines, being one of the cutting-edge new technologies, attracted significant interest and offered a lot of hope. The potential of these vaccines in preventing admission to hospitals and serious illness in people with comorbidities
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Rice starch modification by thermal treatments with avocado oil: Autoclave versus microwave methods Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-05 Sabrina Feksa Frasson, Rosana Colussi, Helen Cristina dos Santos Hackbart, Caroline Dellinghausen Borges, Wladimir Hernandez Flores, Carla Rosane Barboza Mendonça
This study aimed to evaluate the physical and chemical alterations in rice starch modified by heat-moisture treatment (HMT) using an autoclave and a microwave, in association with avocado oil (AO), and evaluate the effects on thermal and structural properties, in vitro digestibility, and estimated glycemic index (eGI). Samples were adjusted to 30 % (/w) moisture and 2, 4 and 8 % AO. HMT was conducted
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Structural characterization of lytic transglycosylase MltD of Pseudomonas aeruginosa, a target for the natural product bulgecin A Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-05 Vega Miguel-Ruano, Rhona Feltzer, María T. Batuecas, Balajee Ramachandran, Amr M. El-Araby, Luis F. Avila-Cobian, Stefania De Benedetti, Shahriar Mobashery, Juan A. Hermoso
Natural product bulgecin A potentiates the activity of β-lactam antibiotics by inhibition of three lytic transglycosylases in , of which MltD is one. MltD exhibits both endolytic and exolytic reactions in the turnover of the cell-wall peptidoglycan and tolerates the presence or absence of stem peptides in its substrates. The present study reveals structural features of the multimodular MltD, presenting
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Low molecular weight chitosan from Pleurotus ostreatus waste and its prebiotic potential Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-05 Divya Yadav, K.V. Harish Prashanth, Pradeep Singh Negi
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Synthesis, characterization and antifungal properties of maleopimaric anhydride modified chitosan Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-05 Lingling Li, Yanran Xu, Zhuo Xu, Chunhua Wu, Qian Chen, Kaimeng Xu, Zhengjun Shi, Xiaoping Rao
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Response surface optimization, purification, characterization and short-chain chitooligosaccharides production from an acidic, thermostable chitinase from Thermomyces dupontii Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-05 Rajni Kumari, Manish Kumar, Pawan K. Dadheech, V. Vivekanand, Nidhi Pareek
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Fucoidan MF4 from Fucus vesiculosus inhibits Lewis lung cancer via STING–TBK1–IRF3 pathway Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-05 Chuanqin Shi, Shihua Zhao, Liyan Mi, Deying Niu, Fanwen Hu, Wenwei Han, Bing Li
Fucoidan, a sulfated polysaccharide of marine origin found in brown algae and sea cucumbers, has been identified as a neuroprotective compound. In this study, a novel fucoidan MF4 was extracted from and isolated using Q-Sepharose fast-flow ion-exchange chromatography. The physicochemical properties of MF4 were characterized. MF4 is primarily composed of fucose, xylose, galactose, glucose, and mannose
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Bacterial cellulose-based hydrogel with regulated rehydration and enhanced antibacterial activity for wound healing Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-05 Lili Deng, Fangzhou Li, Zhiliang Han, Xiangyang Qu, Jing Li, Zhou Zhou, Shiyan Chen, Huaping Wang, Xiangguo Lv
Bacterial cellulose (BC) hydrogels are promising medical biomaterials that have been widely used for tissue repair, wound healing and cartilage engineering. However, the high water content of BC hydrogels increases the difficulty of storage and transportation. Moreover, they will lose their original hydrogel structure after dehydration, which severely limits their practical applications. Introducing
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Chondroitin sulphate modified MoS2 nanoenzyme with multifunctional activities for treatment of Alzheimer's disease Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-05 Jialei Tian, Qian Peng, Yuzhen Shen, Xuan Liu, Delong Li, Jian Li, Shuyuan Guo, Caicai Meng, Yuliang Xiao
Nano-MoS exhibit oxidoreductase-like activities, and has been shown to effectively eliminate excessive intracellular ROS and inhibit Aβ aggregation, thus demonstrating promising potential for anti-Alzheimer's disease (anti-AD) intervention. However, the low water dispersibility and high toxicity of nano-MoS limits its further application. In this study, we developed a chondroitin sulphate (CS)-modified
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Bone morphogenetic protein 15 gene disruption affects the in vitro maturation of porcine oocytes by impairing spindle assembly and organelle function Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-04 Yafei Jiao, Chang Bei, Yixian Wang, Alian Liao, Jinming Guo, Xinran Li, Tiantuan Jiang, Xiaohong Liu, Yaosheng Chen, Peiqing Cong, Zuyong He
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Chitosan-based hybrid nanospheres for vessel normalization towards enhancing tumor chemotherapy Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-04 Ding Wang, Yaoqing Chu, Shuiping Liu, Lianjiang Tan
Vessel normalization has proved imperative in tumor growth inhibition. In this work, biopolymer-based hybrid nanospheres capable of normalizing blood vessels were designed to improve the therapeutic effect of chemotherapeutic drugs. ZnFeO nanoparticles (ZFO NPs) were synthesized, and were encapsulated in cross-inked chitosan (CS) along with a nitric oxide (NO) precursor, DETA NONOate, forming hybrid
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Synthesis, antimicrobial activity, antioxidant activity and molecular docking of novel chitosan derivatives containing glycine Schiff bases as potential succinate dehydrogenase inhibitors Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-04 Jingmin Cui, Yanqing Wang, Xiaorui Liang, Jinyu Zhao, Yuting Ji, Wenqiang Tan, Fang Dong, Zhanyong Guo
Succinate dehydrogenase (SDH) is an important inner mitochondrial membrane-bound enzyme involved in redox reactions during the tricarboxylic acid cycle. Therefore, a series of novel chitosan derivatives were designed and synthesized as potential microbicides targeting SDH and precisely characterized by FTIR, H NMR and SEM. Their antifungal and antibacterial activities were evaluated against , , and
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Starch-fiber foaming biodegradable composites with polylactic acid hydrophobic surface Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-04 Jihua Yang, Yanhui Li, Xinlin Li, Maocheng Ji, Sixian Peng, Jia Man, Lirong Zhou, Fangyi Li, Chuanwei Zhang
Starch and plant fibers are abundant natural polymers that offer biodegradability, making them potential substitutes for plastics in certain applications, but are usually limited by its high hydrophilicity, and low mechanical performance. To address this issue, polylactic acid (PLA) is blended with cellulose and chitosan to create a waterproof film that can be applied to starch-fiber foaming biodegradable
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Synergistic impact of heat and salicylic acid pretreatment on gluten films: Characterization and functional properties Int. J. Biol. Macromol. (IF 8.2) Pub Date : 2024-04-04 Faiza Rasheed, Muhammad Bilal Saeed, Sara Fatima, Anila Sajjad, Muhammad Abdullah Khan, Waqas Khan Kayani
This study investigates how wheat gluten (WG) films in the presence of salicylic acid are influenced by thermal pretreatment. Unlike previous methods conducted at low moisture content, our procedure involves pretreating WG at different temperatures (65 °C, 75 °C, and 85 °C), in a solution with salicylic acid. This pretreatment aims to enhance protein unfolding, thus providing more opportunities for