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Exome sequencing in a Chinese cohort of children with cerebral palsy identifies likely pathogenic variants Nat. Med. (IF 82.9) Pub Date : 2024-05-07
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The future of brain–computer interfaces in medicine Nat. Med. (IF 82.9) Pub Date : 2024-05-07
Growing interest in non-invasive brain–computer interfaces, rather than implants, might improve accessibility for patients, but resolution needs to be improved.
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APOE4 homozygosity is a new genetic form of Alzheimer’s disease Nat. Med. (IF 82.9) Pub Date : 2024-05-06 Qin Xu, Zherui Liang, Yadong Huang
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APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease Nat. Med. (IF 82.9) Pub Date : 2024-05-06 Juan Fortea, Jordi Pegueroles, Daniel Alcolea, Olivia Belbin, Oriol Dols-Icardo, Lídia Vaqué-Alcázar, Laura Videla, Juan Domingo Gispert, Marc Suárez-Calvet, Sterling C. Johnson, Reisa Sperling, Alexandre Bejanin, Alberto Lleó, Víctor Montal
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Pemigatinib in previously treated solid tumors with activating FGFR1–FGFR3 alterations: phase 2 FIGHT-207 basket trial Nat. Med. (IF 82.9) Pub Date : 2024-05-06 Jordi Rodón, Silvia Damian, Muhammad Furqan, Jesús García-Donas, Hiroo Imai, Antoine Italiano, Iben Spanggaard, Makoto Ueno, Tomoya Yokota, Maria Luisa Veronese, Natalia Oliveira, Xin Li, Aidan Gilmartin, Michael Schaffer, Lipika Goyal
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A hierarchical kidney outcome using win statistics in patients with heart failure from the DAPA-HF and DELIVER trials Nat. Med. (IF 82.9) Pub Date : 2024-05-06 Toru Kondo, Pardeep S. Jhund, Samvel B. Gasparyan, Mingming Yang, Brian L. Claggett, Finnian R. McCausland, Paolo Tolomeo, Muthiah Vadagunathan, Hiddo J. L. Heerspink, Scott D. Solomon, John J. V. McMurray
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Equitable implementation of a precision digital health program for glucose management in individuals with newly diagnosed type 1 diabetes Nat. Med. (IF 82.9) Pub Date : 2024-05-03 Priya Prahalad, David Scheinker, Manisha Desai, Victoria Y. Ding, Franziska K. Bishop, Ming Yeh Lee, Johannes Ferstad, Dessi P. Zaharieva, Ananta Addala, Ramesh Johari, Korey Hood, David M. Maahs
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Adapting vision–language AI models to cardiology tasks Nat. Med. (IF 82.9) Pub Date : 2024-05-01 Rima Arnaout
Vision–language models can be trained to read cardiac ultrasound images with implications for improving clinical workflows, but additional development and validation will be required before such models can replace humans.
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Exome sequencing reveals genetic heterogeneity and clinically actionable findings in children with cerebral palsy Nat. Med. (IF 82.9) Pub Date : 2024-05-01 Yangong Wang, Yiran Xu, Chongchen Zhou, Ye Cheng, Niu Qiao, Qing Shang, Lei Xia, Juan Song, Chao Gao, Yimeng Qiao, Xiaoli Zhang, Ming Li, Caiyun Ma, Yangyi Fan, Xirui Peng, Silin Wu, Nan Lv, Bingbing Li, Yanyan Sun, Bohao Zhang, Tongchuan Li, Hongwei Li, Jin Zhang, Yu Su, Qiaoli Li, Junying Yuan, Lei Liu, Andres Moreno-De-Luca, Alastair H. MacLennan, Jozef Gecz, Dengna Zhu, Xiaoyang Wang, Changlian
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The search for authentic microbiome–disease relationships Nat. Med. (IF 82.9) Pub Date : 2024-04-30 Na Jiao, Lixin Zhu, Ruixin Zhu
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Life-long health consequences of undernutrition in the Yanomami indigenous population in Brazil Nat. Med. (IF 82.9) Pub Date : 2024-04-30 Thiago dos Reis Araujo, Ana Paula Davel, Everardo Magalhães Carneiro
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Sustainable, low-cost cancer diagnostics Nat. Med. (IF 82.9) Pub Date : 2024-04-30
Researchers have developed a low-resource, environmentally friendly cancer-diagnosis platform that detects metabolites in dried serum spots.
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Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children Nat. Med. (IF 82.9) Pub Date : 2024-04-30 Youjia Zhong, Alicia Y. H. Kang, Carina J. X. Tay, Hui’ En Li, Nurul Elyana, Chee Wah Tan, Wee Chee Yap, Joey M. E. Lim, Nina Le Bert, Kuan Rong Chan, Eugenia Z. Ong, Jenny G. Low, Lynette P. Shek, Elizabeth Huiwen Tham, Eng Eong Ooi
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Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer: a randomized phase 2 trial Nat. Med. (IF 82.9) Pub Date : 2024-04-30 Martin Schuler, Kristof Cuppens, Till Plönes, Marcel Wiesweg, Bert Du Pont, Balazs Hegedus, Johannes Köster, Fabian Mairinger, Kaid Darwiche, Annette Paschen, Brigitte Maes, Michel Vanbockrijck, David Lähnemann, Fang Zhao, Hubertus Hautzel, Dirk Theegarten, Koen Hartemink, Henning Reis, Paul Baas, Alexander Schramm, Clemens Aigner
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Microbiome confounders and quantitative profiling challenge predicted microbial targets in colorectal cancer development Nat. Med. (IF 82.9) Pub Date : 2024-04-30 Raúl Y. Tito, Sara Verbandt, Marta Aguirre Vazquez, Leo Lahti, Chloe Verspecht, Verónica Lloréns-Rico, Sara Vieira-Silva, Janine Arts, Gwen Falony, Evelien Dekker, Joke Reumers, Sabine Tejpar, Jeroen Raes
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Vision–language foundation model for echocardiogram interpretation Nat. Med. (IF 82.9) Pub Date : 2024-04-30 Matthew Christensen, Milos Vukadinovic, Neal Yuan, David Ouyang
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Telemonitoring of patients with acute coronary syndrome Nat. Med. (IF 82.9) Pub Date : 2024-04-29
A randomized controlled trial involving a telemedicine-based approach for the management of patients with acute coronary syndrome had several clinical benefits relative to standard of care.
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AI-enabled electrocardiography alert intervention and all-cause mortality: a pragmatic randomized clinical trial Nat. Med. (IF 82.9) Pub Date : 2024-04-29 Chin-Sheng Lin, Wei-Ting Liu, Dung-Jang Tsai, Yu-Sheng Lou, Chiao-Hsiang Chang, Chiao-Chin Lee, Wen-Hui Fang, Chih-Chia Wang, Yen-Yuan Chen, Wei-Shiang Lin, Cheng-Chung Cheng, Chia-Cheng Lee, Chih-Hung Wang, Chien-Sung Tsai, Shih-Hua Lin, Chin Lin
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The health risks of generative AI-based wellness apps Nat. Med. (IF 82.9) Pub Date : 2024-04-29 Julian De Freitas, I. Glenn Cohen
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Influence of COVID-19 on trust in routine immunization, health information sources and pandemic preparedness in 23 countries in 2023 Nat. Med. (IF 82.9) Pub Date : 2024-04-29 Jeffrey V. Lazarus, Trenton M. White, Katarzyna Wyka, Scott C. Ratzan, Kenneth Rabin, Heidi J. Larson, Federico Martinon-Torres, Ernest Kuchar, Salim S. Abdool Karim, Tamara Giles-Vernick, Selina Müller, Carolina Batista, Nellie Myburgh, Beate Kampmann, Ayman El-Mohandes
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The argument framework is a flexible approach to evidence in healthcare Nat. Med. (IF 82.9) Pub Date : 2024-04-26 Jonathan Fuller, Benjamin Chin-Yee, Ross E. G. Upshur
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Bispecific T cell engager therapy for refractory rheumatoid arthritis Nat. Med. (IF 82.9) Pub Date : 2024-04-26 Laura Bucci, Melanie Hagen, Tobias Rothe, Maria Gabriella Raimondo, Filippo Fagni, Carlo Tur, Andreas Wirsching, Jochen Wacker, Artur Wilhelm, Jean-Philippe Auger, Milena Pachowsky, Markus Eckstein, Stefano Alivernini, Angelo Zoli, Gerhard Krönke, Stefan Uderhardt, Aline Bozec, Maria-Antonietta D’Agostino, Georg Schett, Ricardo Grieshaber-Bouyer
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Reproductive rights in the United States: acquiescence is not a strategy Nat. Med. (IF 82.9) Pub Date : 2024-04-25 Laura J. Esserman, Douglas Yee
Scientific and medical conferences should not be held in states that ban abortion, as such bans put the lives of women at risk.
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Large language models for preventing medication direction errors in online pharmacies Nat. Med. (IF 82.9) Pub Date : 2024-04-25 Cristobal Pais, Jianfeng Liu, Robert Voigt, Vin Gupta, Elizabeth Wade, Mohsen Bayati
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Urgent action is needed to confront artemisinin partial resistance in African malaria parasites Nat. Med. (IF 82.9) Pub Date : 2024-04-25
Discover the world’s best science and medicine | Nature.com
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New risk score for cardiovascular disease with improved performance Nat. Med. (IF 82.9) Pub Date : 2024-04-23
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Nivolumab for mismatch-repair-deficient or hypermutated gynecologic cancers: a phase 2 trial with biomarker analyses Nat. Med. (IF 82.9) Pub Date : 2024-04-23 Claire F. Friedman, Beryl L. Manning-Geist, Qin Zhou, Tara Soumerai, Aliya Holland, Arnaud Da Cruz Paula, Hunter Green, Melih Arda Ozsoy, Alexia Iasonos, Travis Hollmann, Mario M. Leitao, Jennifer J. Mueller, Vicky Makker, William P. Tew, Roisin E. O’Cearbhaill, Ying L. Liu, Maria M. Rubinstein, Tiffany Troso-Sandoval, Stuart M. Lichtman, Alison Schram, Chrisann Kyi, Rachel N. Grisham, Pamela Causa
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The hype and hope of new food allergy treatments Nat. Med. (IF 82.9) Pub Date : 2024-04-22 Kirsten P. Perrett
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Strategies for controlling pneumococcal disease and outbreaks during humanitarian emergencies Nat. Med. (IF 82.9) Pub Date : 2024-04-22 Molly Cliff, Paul Welaga, Nuredin Mohammed, Patrick Ansah, Robert S. Heyderman, Caroline Trotter, Brenda Kwambana-Adams
Streptococcus pneumoniae infection accounts for nearly one-fifth of all meningitis deaths globally, half of which occur in Sub-Saharan Africa. Pneumococcal conjugate vaccines (PCVs) prevent vaccine-serotype disease and have been rolled out as part of infant immunization programs worldwide1. Despite widespread PCV usage, the burden of pneumococcal meningitis remains highest within the so called ‘African
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mRNA therapy for a rare childhood disease Nat. Med. (IF 82.9) Pub Date : 2024-04-22
An mRNA-based drug aims to replace a faulty enzyme and restore metabolic function in children with propionic acidemia — with encouraging early clinical results.
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Repurposing a diabetes drug to treat Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2024-04-20
In a multicenter clinical trial, patients with early-stage Parkinson’s disease treated with lixisenatide, a drug currently used for the treatment of diabetes, showed improvement in their motor scores compared with those on placebo.
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Using unlabeled data to enhance fairness of medical AI Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Rajiv Movva, Pang Wei Koh, Emma Pierson
AI models for tasks such as pathology and dermatology struggle to generalize to new patient groups or hospitals that they were not trained on; learning more robust features from unlabeled data could prevent overfitting to the training distribution and thereby increase fairness.
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Microplastics are everywhere — we need to understand how they affect human health Nat. Med. (IF 82.9) Pub Date : 2024-04-19
As evidence emerges describing the accumulation of small plastic particles in various organs and tissues of the body, a much deeper understanding of the effects of these particles on human health is urgently needed.
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Demographic bias in misdiagnosis by computational pathology models Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Anurag Vaidya, Richard J. Chen, Drew F. K. Williamson, Andrew H. Song, Guillaume Jaume, Yuzhe Yang, Thomas Hartvigsen, Emma C. Dyer, Ming Y. Lu, Jana Lipkova, Muhammad Shaban, Tiffany Y. Chen, Faisal Mahmood
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Risk-based lung cancer screening performance in a universal healthcare setting Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Martin C. Tammemägi, Gail E. Darling, Heidi Schmidt, Meghan J. Walker, Deanna Langer, Yvonne W. Leung, Kathy Nguyen, Beth Miller, Diego Llovet, William K. Evans, Daniel N. Buchanan, Gabriela Espino-Hernandez, Usman Aslam, Amanda Sheppard, Aisha Lofters, Micheal McInnis, Julian Dobranowski, Steven Habbous, Christian Finley, Marianne Luettschwager, Erin Cameron, Caroline Bravo, Anna Banaszewska, Katherin
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Climate change and health: understanding mechanisms will inform mitigation and prevention strategies Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Diddier Prada, Andrea A. Baccarelli, Allison Kupsco, Robbie M. Parks
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Post-election responsibilities for public health in the Democratic Republic of the Congo Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Faraan O. Rahim, William C. Lieber, Julian T. Hertz, Bruce Shinga Wembulua, Patrick A. Ndeba, Richard M. Lukelwa
Since gaining independence in 1960, the Democratic Republic of the Congo (DRC) has faced a complicated series of challenges marked by armed conflict, political instability and economic hardships. Tensions in the DRC are on an escalating trajectory as the Congolese army and its allied militias battle with the March 23 Movement group in North and South Kivu. Attempts to restore peace through the Nairobi
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Opportunities and challenges following approval of resmetirom for MASH liver disease Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Jeffrey V. Lazarus, Dana Ivancovsky Wajcman, Henry E. Mark, Zobair M. Younossi, Christopher J. Kopka, Nevin Cohen, Meena B. Bansal, Michael Betel, Paul N. Brennan
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An autoantibody signature predictive for multiple sclerosis Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Colin R. Zamecnik, Gavin M. Sowa, Ahmed Abdelhak, Ravi Dandekar, Rebecca D. Bair, Kristen J. Wade, Christopher M. Bartley, Kerry Kizer, Danillo G. Augusto, Asritha Tubati, Refujia Gomez, Camille Fouassier, Chloe Gerungan, Colette M. Caspar, Jessica Alexander, Anne E. Wapniarski, Rita P. Loudermilk, Erica L. Eggers, Kelsey C. Zorn, Kirtana Ananth, Nora Jabassini, Sabrina A. Mann, Nicholas R. Ragan,
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Causal machine learning for predicting treatment outcomes Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Stefan Feuerriegel, Dennis Frauen, Valentyn Melnychuk, Jonas Schweisthal, Konstantin Hess, Alicia Curth, Stefan Bauer, Niki Kilbertus, Isaac S. Kohane, Mihaela van der Schaar
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Development and validation of a new algorithm for improved cardiovascular risk prediction Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Julia Hippisley-Cox, Carol A. C. Coupland, Mona Bafadhel, Richard E. K. Russell, Aziz Sheikh, Peter Brindle, Keith M. Channon
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Targeting KRAS in cancer Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Anupriya Singhal, Bob T. Li, Eileen M. O’Reilly
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An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Amit Saraf, Rohan Gurjar, Swarnendu Kaviraj, Aishwarya Kulkarni, Durgesh Kumar, Ruta Kulkarni, Rashmi Virkar, Jayashri Krishnan, Anjali Yadav, Ekta Baranwal, Ajay Singh, Arjun Raghuwanshi, Praveen Agarwal, Laxman Savergave, Sanjay Singh
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The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy Nat. Med. (IF 82.9) Pub Date : 2024-04-17 Ryan M. Jamiolkowski, Quynh-Anh Nguyen, Jordan S. Farrell, Ryan J. McGinn, David A. Hartmann, Jeff J. Nirschl, Mateo I. Sanchez, Vivek P. Buch, Ivan Soltesz
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Nicotine e-cigarettes: considerations for healthcare providers Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Benjamin A. Toll, Tracy T. Smith, Brian A. King
Tobacco use continues to be the leading cause of preventable disease and death in the United States. There are no safe tobacco products; however, the health risks for tobacco products exist on a continuum, with combustible products such as cigarettes being the most harmful. Decades of research have documented that cigarette smoking harms nearly every organ of the body; cigarette smoke contains nearly
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A framework for implementing patient-reported outcomes in clinical care: the PROTEUS-practice guide Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Norah L. Crossnohere, Nicola Anderson, Judith Baumhauer, Melanie Calvert, Rebecca Esparza, Sandi Gulbransen, Lotte Haverman, Yuchen Li, Carolyn Petersen, Ameeta Retzer, Christopher Sidey-Gibbons, Angela M. Stover, Elissa Thorner, Garrett Ursin, Galina Velikova, Elliott Sparkman Walker, Michael Brundage, Claire Snyder
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Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Marie-France Hivert, Frédérique White, Catherine Allard, Kaitlyn James, Sana Majid, François Aguet, Kristin G. Ardlie, Jose C. Florez, Andrea G. Edlow, Luigi Bouchard, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe
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Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Fei Tian, Dong Liu, Na Wei, Qianqian Fu, Lin Sun, Wei Liu, Xiaolong Sui, Kathryn Tian, Genevieve Nemeth, Jingyu Feng, Jingjing Xu, Lin Xiao, Junya Han, Jingjie Fu, Yinhua Shi, Yichen Yang, Jia Liu, Chunhong Hu, Bin Feng, Yan Sun, Yunjun Wang, Guohua Yu, Dalu Kong, Meiyun Wang, Wencai Li, Kexin Chen, Xiangchun Li
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Transparent medical image AI via an image–text foundation model grounded in medical literature Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Chanwoo Kim, Soham U. Gadgil, Alex J. DeGrave, Jesutofunmi A. Omiye, Zhuo Ran Cai, Roxana Daneshjou, Su-In Lee
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Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2024-04-15 Gennaro Pagano, Kirsten I. Taylor, Judith Anzures Cabrera, Tanya Simuni, Kenneth Marek, Ronald B. Postuma, Nicola Pavese, Fabrizio Stocchi, Kathrin Brockmann, Hanno Svoboda, Dylan Trundell, Annabelle Monnet, Rachelle Doody, Paulo Fontoura, Geoffrey A. Kerchner, Patrik Brundin, Tania Nikolcheva, Azad Bonni
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Designer antibiotics by generative AI Nat. Med. (IF 82.9) Pub Date : 2024-04-12
Researchers developed an AI model that designs novel, synthesizable antibiotic compounds — several of which showed potent in vitro activity against priority pathogens.
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Why diversity is needed at every level of clinical trials, from participants to leaders Nat. Med. (IF 82.9) Pub Date : 2024-04-11 Khadijah Breathett
Diversity in clinical trials must be accompanied by justice and equity, including benefits for underrepresented participants, in order to boost population health.
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Functional precision medicine for pediatric cancers Nat. Med. (IF 82.9) Pub Date : 2024-04-11 M. Emmy M. Dolman, Paul G. Ekert
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Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers Nat. Med. (IF 82.9) Pub Date : 2024-04-11 Arlet M. Acanda De La Rocha, Noah E. Berlow, Maggie Fader, Ebony R. Coats, Cima Saghira, Paula S. Espinal, Jeanette Galano, Ziad Khatib, Haneen Abdella, Ossama M. Maher, Yana Vorontsova, Cristina M. Andrade-Feraud, Aimee Daccache, Alexa Jacome, Victoria Reis, Baylee Holcomb, Yasmin Ghurani, Lilliam Rimblas, Tomás R. Guilarte, Nan Hu, Daria Salyakina, Diana J. Azzam
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Generative models improve fairness of medical classifiers under distribution shifts Nat. Med. (IF 82.9) Pub Date : 2024-04-10 Ira Ktena, Olivia Wiles, Isabela Albuquerque, Sylvestre-Alvise Rebuffi, Ryutaro Tanno, Abhijit Guha Roy, Shekoofeh Azizi, Danielle Belgrave, Pushmeet Kohli, Taylan Cemgil, Alan Karthikesalingam, Sven Gowal
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‘Inverse vaccines’ could treat autoimmune disease — from multiple sclerosis to celiac disease Nat. Med. (IF 82.9) Pub Date : 2024-04-10
Nature Medicine explores the latest translational and clinical research news, with clinical trials testing glycosylated autoantigens as immunotolerance therapies.
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Tackling heat-related mortality in aging populations Nat. Med. (IF 82.9) Pub Date : 2024-04-08 Josiah L. Kephart, Safiyyah M. Okoye
A large study of older adults in China points to physical and cognitive function — not age — as key predictors of heat-related mortality, highlighting the need for climate adaptation policies to prioritize accessibility across all age groups.
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Food is medicine: clinical trials show the health benefits of dietary interventions Nat. Med. (IF 82.9) Pub Date : 2024-04-08
Growing evidence shows that dietary interventions can be effective at treating or delaying some diseases, but further trials are needed for wider adoption.
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Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs Nat. Med. (IF 82.9) Pub Date : 2024-04-08 Adrienne Y. L. Chan, Le Gao, Miyuki Hsing-Chun Hsieh, Lars J. Kjerpeseth, Raquel Avelar, Tobias Banaschewski, Amy Hai Yan Chan, David Coghill, Jacqueline M. Cohen, Mika Gissler, Jeff Harrison, Patrick Ip, Øystein Karlstad, Wallis C. Y. Lau, Maarit K. Leinonen, Wing Cheong Leung, Tzu-Chi Liao, Johan Reutfors, Shih-Chieh Shao, Emily Simonoff, Kathryn Choon Beng Tan, Katja Taxis, Andrew Tomlin, Carolyn
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Continuous glucose monitoring and intrapersonal variability in fasting glucose Nat. Med. (IF 82.9) Pub Date : 2024-04-08 Smadar Shilo, Ayya Keshet, Hagai Rossman, Anastasia Godneva, Yeela Talmor-Barkan, Yaron Aviv, Eran Segal