1762
中文   |   English 手机浏览
当前位置： 首页   >  成果及论文
成果及论文

  1. Cui,J#.; Zheng, Q#.; Weng, Y#; Zhai,X.; Su,Z.; Du,Y.; Wei, X.; Yu.Y.*; Qu, Q.*; Pan. M.*, Structure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs,   Angew Chem Int Ed Engl, 2025, e202501488. 10.1002/anie.202501488

  2. Cai, H.#; Wu, X#.; Mao, J.; Tong, Z. ; Yan, D; Weng,Y*;  Zheng, Q*; Sequential release of interacting proteins and Ub-modifying enzymes by disulfide heterotypic ubiquitin reagents, Bioorg Chem, 2024, 145, 107186

  3. Zhang, L.#; Du, Y.#; Qu, Q.*; Zheng, Q*.; Structure basis of the phytoplasma effector SAP05 recognition specificities to plant Rpn10 in ubiquitin-independent protein degradation. iScience, 2023,27(2), 108892.

  4. Mao, J.#; Ai, H.#; Wu, X.#; Zheng, Q*.; Cai, H.; Liang, L.; Tong, Z.; Pan, M.*; Liu, L.*; Structural visualization of HECT-E3 Ufd4 accepting and transferring ubiquitin to form K29/K48-branched polyubiquitination on N-degron. BioRxiv, 2023, 2023.05.23.542033.

  5.  Zheng, Q.#; Tian, W.#; Mao, J.#; Chu, G.; Liang, L.; Jing, Y. Zuo, C.; Yu, Y.; Hu, H.*; Pan, M.*, Synthesis of mimics in ubiquitination reading, writing and erasing processes by a bifunctional molecule-assisted strategy. Nat Protoc 2023,18(2),530-554.

  6. Zheng, Q.#; Su, Z.; Yu, Y.*; Liu, L.*, Recent progress in dissecting ubiquitin signals with chemical biology tools. Curr Opin Chem Bio 2022, 70, 102187.

  7. Pan, M.#;  Zheng, Q.#;  Wang, T.#;  Liang, L.#;  Mao, J.;  Zuo, C.;  Ding, R.;  Ai, H.;  Xie, Y.;  Si, D.;  Yu, Y.;  Liu, L.*; Zhao, M.*, Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature 2021, 600 (7888), 334-338.

  8.  Pan, M.#;  Zheng, Q.#;  Yu, Y.;  Ai, H. S.;  Xie, Y.;  Zeng, X.;  Wang, C.;  Liu, L.*; Zhao, M.*, Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. Nat Commun 2021, 12 (1), 121-133.

  9.  Yu, Y.#;  Zheng, Q.#;  Erramilli, S. K.#;  Pan, M.#*;  Park, S.;  Xie, Y.;  Li, J.;  Fei, J.;  Kossiakoff, A. A.*;  Liu, L.*; Zhao, M.*, K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. Nat Chem Biol 2021, 17 (8), 896-905.

  10.  Zheng, Q.#;  Wang, T.#;  Chu, G. C.#;  Zuo, C.;  Zhao, R.;  Sui, X.;  Ye, L. Z.;  Yu, Y. Y.;  Chen, J. N.;  Wu, X. W.;  Zhang, W. H.;  Deng, H. T.;  Shi, J.;  Pan, M.;  Li, Y. M.*; Liu, L.*, An E1-Catalyzed Chemoenzymatic Strategy to Isopeptide-N-Ethylated Deubiquitylase-Resistant Ubiquitin Probes. Angew Chem Int Ed Engl 2020, 59 (32), 13496-13501.

  11. Pan, M.#; Zheng, Q.#;  Ding, S.#;  Zhang, L.#;  Qu, Q.;  Wang, T.;  Hong, D.;  Ren, Y.;  Liang, L.;  Chen, C.*;  Mei, Z.*; Liu, L.*, Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains. Angew Chem Int Ed Engl 2019, 58 (9), 2627-2631.

  12.  Pan, M.#;  Zheng, Q.#;  Gao, S.;  Qu, Q.;  Yu, Y.;  Wu, M.;  Lan, H.;  Li, Y.;  Liu, S.;  Li, J.;  Sun, D.;  Lu, L.;  Wang, T.;  Zhang, W.;  Wang, J.;  Li, Y.;  Hu, H.-G.*;  Tian, C.*; Liu, L.*, Chemical Synthesis of Structurally Defined Phosphorylated Ubiquitins Suggests Impaired Parkin Activation by Phosphorylated Ubiquitins with a Non-Phosphorylated Distal Unit. CCS Chem. 2019, 1 (5), 476-489.