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成果及论文

一、承担项目    

  1. 国家自然科学基金面上项目，32571469，2026-2029，主持

  2. 国家自然科学基金面上项目，32371322，2024-2027，主持

  3. 湖湘青年科技创新人才项目，2021RC3092，2021-2023，主持

  4. 国家自然科学基金青年基金项目，31800655，2019-2021，主持

  5. 湖南省自然科学基金青年基金项目，2020JJ5359，2020-2022，主持

  6. 湖南省教育厅重点项目，24A0059，2024-2026，主持

  7. 湖南省教育厅优秀青年项目，22B0069，2022-2024，主持

  8. 中国博士后科学基金，2018M632968，2018-2019，主持

  9. 重点实验室开放课题，HPKL2023030，2023-2025，主持

 二、发表论文（一作及通讯作者）

  1. Zhou X#,*, Chen H#, Peng S, Si Y, Wang G, Yang L, Zhou Q, Lu M, Xie Q, He X, Wu M, Xiao X, Luo X, Feng X, Wang W, Luo S, Li Y, Qin J, Chen M, Zhang Q, Hu W, Liang S, Hou T*, Liu Z*. Inherent fast inactivation particle of Nav channels as a new binding site for a neurotoxin. EMBO Journal. 2025,44(11):3180-3209. （第一及通讯作者）
  2. Zhou X#, Ma T#, Yang L, Peng S, Li L, Wang Z, Xiao Z, Zhang Q, Wang L, Huang Y, Chen M, Liang S, Zhang X, Liu J* & Liu Z*. Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels. Nature Communications. 2020, 11, 2293. （第一作者）
  3. Luo S#, Zhou X#*, Wu M, Wang G, Wang L, Feng X, Wu H, Luo R, Lu M, Ju J, Wang W, Yuan L, Luo X, Peng D, Yang L, Zhang Q, Chen M, Liang S, Dong X, Hao G, Zhang Y*, Liu Z*. Optimizing Nav1.7-Targeted analgesics: revealing off-target effects of spider venom-derived peptide toxins and engineering strategies for improvement. Advanced Science. 2024:e2406656.（共同第一及通讯作者）
  4. Wang, G., Wu, H., Wang, Y., Liu, X., Peng, S., Wang, W., Wu, M., Liu, Y., Wang, E., Wang, Z., Xu, L., Wang, X.*, Yang, W.*, Chen, H.*, Zhou, X.*, and Hou, T.* Discovery of Novel Na(v)1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief. Research . 2025,8, 0599（通讯作者）
  5. Chen M, Peng S, Xiao Z*, Liu Z*, Zhou X*. Multiple gating processes associated with the distal end of S6 segment of Domain II in the Nav channels. Journal of Biological Chemistry . 2025,301,108060.（通讯作者）
  6. Chen, M., Yang, L., Zeng, G., Xiao, X., Liu, Z.*, Zhang, G.*, and Zhou, X.* Isolation and identification of toxins inhibiting Shal potassium channels from the venom of Ornithoctonus hainana spider. Toxicology and Applied Pharmacology. 2025,500, 117374.（通讯作者）
  7. Xiao, Z., You, X., Chen, M., Li, H., Chen, B., Hu, Z., You, Q., Liu, H., Zhao, P.*, Zhou, X.*, and Liu, Z.* A novel spider toxin as a selective antagonist of the Kv1 subfamily of voltage-gated potassium channels through gating modulation. Journal of Biological Chemistry , 2025,108341（通讯作者）
  8. Peng S, Chen M, Wu M, Liu Z, Tang D*, Zhou X*. Elucidating the roles of voltage sensors in NaV1.9 activation and inactivation through a spider toxin. Biochim Biophys Acta Gen Subj. 2025,10;1869(3):130762.（通讯作者）
  9. Zhou, S., Zhang, Q., Xu, J., Xiang, R., Dong, X., Zhou, X.*, and Liu, Z*. CAP superfamily proteins in human: a new target for cancer therapy. Medical Oncology. 2024,41, 306（通讯作者）
  10. Xiao X#, Luo X#, Huang C#, Feng X, Wu M, Lu M, Kuang J, Peng S, Guo Y, Zhang Z, Hu Z, Zhou X*, Chen M*, and Liu Z*. Transcriptome analysis reveals the peptide toxins diversity of Macrothele palpator venom. International Journal of Biological Macromolecules. 2023, 253, 126577.  （通讯作者）
  11. Chen M #, Lu M#, Feng X#, Wu M, Luo X, Xiang R, Luo R, Wu H, Liu Z, Wang M*, and Zhou X*. LmNaTx15, a novel scorpion toxin, enhances the activity of Nav channels and induces pain in mice. Toxicon. 2023, 236, 107331.（通讯作者）
  12. Zhang, Q., Xu, J., Zhou, X.*, and Liu, Z*. CAP superfamily proteins from venomous animals: Who we are and what to do? International Journal of Biological Macromolecules. 2022, 221, 691-702（通讯作者）
  13. Zhao, C., Jin, J., Hu, H., Zhou, X.*, and Shi, X.* The Gain-of-Function R222S Variant in Scn11a Contributes to Visceral Hyperalgesia and Intestinal Dysmotility in Scn11aR222S/R222S Mice. Frontiers in Neurology. 2022, 13（通讯作者）
  14. Peng S#, Chen M#, Xiao Z, Xiao X, Luo S, Liang S, Zhou X* and Liu Z*. A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors. Frontiers in Pharmacology. 2021.12:778534.（通讯作者）
  15. Zhang Q#, Si Y#, Yang L#, Wang L, Peng S, Chen Y, Chen M, Zhou X*, and Liu Z*.Two novel peptide toxins from the spider cyriopagopus longipes inhibit tetrodotoxin-sensitive sodium channels. Toxins.2020,12 (9):529.    （通讯作者）
  16. Chen M, Peng S, Wang L, Yang L, Si Y, Zhou X*, Zhang *Y, Liu Z*. Recombinant PaurTx-3, a spider toxin, inhibits sodium channels and decreases membrane excitability in DRG neurons. Biochem Biophys Res Commun. 2020,17;533(4):958-964.（通讯作者）
  17. Zhao C, Tang D, Huang H, Tang H, Yang Y, Yang M, Luo Y, Tao H, Tang J, Zhou X*, Shi X*. Myotonia congenita and periodic hypokalemia paralysis in a consanguineous marriage pedigree: Coexistence of a novel CLCN1 mutation and an SCN4A mutation. PLoS One. 2020,14;15(5):e0233017.  （通讯作者）
  18. Zhou, X#., Zhang, Y#., Tang, D#., Liang, S., Chen, P., Tang, C. *, and Liu, Z*. A Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line. Frontiers in Pharmacology. 2018, 9. （第一作者）
  19. Zhou, X. #, Xiao, Z. #, Xu, Y., Zhang, Y., Tang, D., Wu, X., Tang, C., Chen, M., Shi, X., Chen, P. *, Liang, S. *, and Liu, Z. * Electrophysiological and Pharmacological Analyses of Nav1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System. Frontiers in Pharmacology. 2017, 8.  （第一作者）
  20. Hu, Z., Chen, B., Xiao, Z., Zhou, X. *, and Liu, Z*.Transcriptomic Analysis of the Spider Venom Gland Reveals Venom Diversity and Species Consanguinity. Toxins. 2019,11, 68. （通讯作者）   
  21. Zhang, Y. #, Yang, Q. #, Zhang, Q., Peng, D., Chen, M., Liang, S., Zhou, X. *, and Liu, Z*. Engineering Gain-of-Function Analogues of the Spider Venom Peptide HNTX-I, A Potent Blocker of the hNa(V)1.7 Sodium Channel. Toxins. 2018,10, 358.  （通讯作者） 
  22. Tang, C.#, Zhou, X.#, Nguyen, P. T., Zhang, Y., Hu, Z., Zhang, C., Yarov-Yarovoy, V., DeCaen, P. G., Liang, S., and Liu, Z. A novel tarantula toxin stabilizes the deactivated voltage sensor of bacterial sodium channel. FASEB J. 2017.31, 3167-3178.  （共同第一作者） 
  23. Tang C#, Zhou X#, Zhang Y, Xiao Z, Hu Z, Zhang C, Huang Y, Chen B, Liu Z, Liang S. Synergetic Action of Domain II and IV Underlies Persistent Current Generation in Nav1.3 as revealed by a tarantula toxin. Sci Rep. 2015; 5: 9241.    （共同第一作者）

三、专利/软件著作        

  1. 生物毒素数据库软件[简称：BioTD] V1.0，授权，软件著作

  2. 一种1H-吲哚-3-丙酰胺类钠通道调控剂的应用，授权，国家发明专利

  3. 少棘蜈蚣多肽毒素rpTx-1、rpTx-2和rpTx-3及其编码基因和应用，授权，国家发明专利

  4. 一种具有Nav1.9特异激活作用的蜘蛛多肽毒素及其应用，授权，国家发明专利

  5. mGpTx1-SA 及其应用，申请，国家发明专利

  6. 一种来源于触形大疣蛛的多肽毒素Mp3c的应用，申请，国家发明专利

  7. 一种电压门控钠离子通道Nav1.9异源表达系统及应用，申请，国家发明专利

  8. 蜈蚣毒素蛋白SHVCAP的应用，申请，国家发明专利

  9. 一种蝎毒多肽LmTx-1及其应用， 申请，国家发明专利

四、成果转化

  1. 多肽LVTX-VI及其应用，2023