近年来发表代表性论文（†共同第一作者，*通讯作者）

1. Tian Tian†*, Ting Zhang†, Wanting Zhang†, Xinyi Guo, Yuxin Chen, Mei Lin, Zhiqiang Qiu, Weiwei Qi, Yutin Shen, Mengen Hao, Hongrui Xiao, Bo Xiang, Feibiao Pang, Jinzhao Song*, Baoqing Sun*, Meng Cheng*, and Xiaoming Zhou*, Identification of Thermotolerant Non-canonical PAMs for Robust One-Pot CRISPR-Cas12a Detection, Nature Communications, 2025, accepted in principle.

2. Qiang Su†, Yi Long†, Deing Gou, Junmin Quan, Xiaoming Zhou*, Qizhou Lian*, Deep structural clustering reveals hidden systematic biases in RNA sequencing data, Genome Research, 2025, 35, 2563.

3. Menglu Hu†*, Yihui Wang†, Weiwei Qi, Yuqing Zhang, Jiachen Sun, Meng Cheng, Xiaoming Zhou*, Photocontrolled Programmable Enzymatic Cascade for Robust CRISPR Diagnostics, J. Am. Chem. Soc. 2025, 147, 31004.

4. Tian Tian†*, Hongrui Xiao†, Xinyi Guo, Yuxin Chen, Zhiqiang Qiu, Ting Zhang, Meiyu Chen, Weiwei Qi, Peige Cai, Meng Cheng, and Xiaoming Zhou*, Identification of a Key Nucleotide Influencing Cas12a crRNA Activity for Universal Photo-controlled CRISPR Diagnostics, Nature Communications, 2025, 16, 6694.

5. Mei Lin†, Zhiqiang Qiu†, Mengen Hao, Weiwei Qi, Ting Zhang, Yuting Shen, Hongrui Xiao, Chaoyue Liang, Longxu Xie, Meng Cheng*, Tian Tian*, Xiaoming Zhou*, Cas12a Cis-cleavage mediated lateral flow assay enables multiplex and ultra-specific nucleic acid detection, Nature Communications, 2025, 16, 5597.

6. Menglu Hu†, Bingni Zhang†, Yuanyue Shan†, Feng Cao, Yihui Wang, Xue Wang, Yuting Shen, Xinyi Guo, Mengmeng Zhang, Tian Tian, Wei Xie, Mingfeng Zhang*, Fang Liang*, Duanqing Pei*, and Xiaoming Zhou*, Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA , Nature Communications, 2025, 16, 5939.

7. Lin Chen, Menglu Hu*, Xiaoming Zhou*, Trends in developing one-pot CRISPR diagnostics strategies, Trends in Biotechnology, 2025, 43(1), 98-110.

8. Tian Tian, Xiaoming Zhou*, CRISPR-Based Biosensing Strategies: Technical Development and Application Prospects, Annual Review of Analytical Chemistry, 2023,16:311–32.

9. Menglu Hu†, Ruhan Liu†, Zhiqiang Qiu, Feng Cao, Tian Tian, Yunxin Lu, Yongzhong Jiang, and Xiaoming Zhou*, Light-start CRISPR‒Cas12a reaction with caged crRNA enables rapid and sensitive nucleic acid detection, Angew. Chem. Int. Ed., 2023, e202300663.

10. Menglu Hu†, Zhiqiang Qiu†, Zirong Bi, Tian Tian, Yongzhong Jiang, and Xiaoming Zhou*, Photocontrolled crRNA activation enables robust CRISPR-Cas12a diagnostics, PNAS, 2022, 119, e2202034119.

11. Mengqi Huang†, Erhu Xiong†*, Yan Wang, Menglu Hu, Huahua Yue, Tian Tian, Debin Zhu, Hong Liu, and Xiaoming Zhou*, Fast microwave heating-based one-step synthesis of DNA and RNA modified gold nanoparticles, Nature Communications, 2022, 13, 968.

12. Mei Lin, Huahua Yue, Tian Tian, Erhu Xiong, Debin Zhu, Yongzhong Jiang*, and Xiaoming Zhou*, Glycerol additive boosts 100-fold sensitivity enhancement for one-pot RPA-CRISPR/Cas12a assay, Analytical Chemistry, 2022, 94, 8277-8284.

13. Tian Tian†, Zhiqiang Qiu†, Yongzhong Jiang, Debin Zhu, Xiaoming Zhou*, Exploiting the orthogonal CRISPR-Cas12a/Cas13a trans-cleavage for dual-gene virus detection using a handheld device, Biosensors and Bioelectronics 196 (2022) 113701.

14. Huahua Yue, Bowen Shu*, Tian Tian, Erhu Xiong, Mengqi Huang, Debin Zhu, Jian Sun, Qing Liu, Shichan Wang, Yirong Li, and Xiaoming Zhou*, Droplet Cas12a Assay Enables DNA Quantifification from Unamplified Samples at the Single-Molecule Level, Nano Letters, 2021, 21, 4643−4653.

15. Huahua Yue, Mengqi Huang, Tian Tian, Erhu Xiong, and Xiaoming Zhou*, Advances in Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)-Based Diagnostic Assays Assisted by Micro/Nanotechnologies, ACS Nano, 2021, 15, 7848−7859.

16. Tian Tian, Bowen Shu*, Yongzhong Jiang, Miaomiao Ye, Lei Liu, Zhang Wang, Zhonghui Guo, Zeping Han, Xiaoming Zhou*, An Ultralocalized Cas13a Assay Enables Universal and Nucleic Acid Amplification-Free Single-Molecule RNA Diagnostics, ACS Nano, 2021, 15, 1167−1178.

17. Erhu Xiong†, Ling Jiang†, Tian Tian, Menglu Hu, Huahua Yue, Mengqi Huang, Wei Lin, Yongzhong Jiang, Debin Zhu, and Xiaoming Zhou*, Simultaneous dual-gene diagnosis of SARS-CoV-2 based on CRISPR/Cas9-mediated lateral flow assay, Angew Chem Int Ed, 2021, 60, 5307−5315.

18. Menglu Hu, Chaoqun Yuan, Tian Tian, Xusheng Wang, Jian Sun, Erhu Xiong*, Xiaoming Zhou*, Single-step, salt aging-free and thiol-free freezing construction of AuNP-based bioprobes for advancing CRISPR-based diagnostics, J. Am. Chem. Soc. 2020, 142, 7506−7513.

19. Xusheng Wang, Erhu Xiong*, Tian Tian, Meng Cheng, Wei Lin, Heng Wang, Guihong Zhang, Jian Sun*, and Xiaoming Zhou*, Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Mediated Lateral Flow Nucleic Acid Assay, ACS Nano, 2020, 14, 2497−2508.

20. Chaoqun Yuan†, Tian Tian†, Jian Sun†, Menglu Hu, Xusheng Wang, Erhu Xiong, Meng Cheng, Yijuan Bao, Wei Lin, Jieming Jiang, Chengwei Yang, Qian Chen, Huang Zhang, Heng Wang, Xiran Wang, Xianbo Deng, Xiaoping Liao, Yahong Liu, Zhang Wang*, Guihong Zhang*, Xiaoming Zhou*, Universal and Naked-Eye Gene Detection Platform Based on CRISPR/Cas12a/13a System, Analytical Chemistry, 2020, 92, 4029−4037.

21. Qian Chen, Tian Tian, Erhu Xiong, Po Wang*, and Xiaoming Zhou*, CRISPR/Cas13a Signal Amplification Linked Immunosorbent Assay for Femtomolar Protein Detection, Analytical Chemistry, 2020, 92, 573-577.

22. Xiaoming Zhou, DebinZhu, Yuhui Liao, Weipeng Liu, Hongxing Liu, Zhaokui Ma, Da Xing*, Synthesis, labelling, and bioanalytical applications of a tris (2, 2'-bipyridyl) ruthenium (II) based electrochemiluminescence probe, Nature Protocols, 2014, 9, 1146-1159.