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成果及论文

Peer-Reviewed Journals (# denotes equal contribution, * denotes corresponding authors)

2024年

Feng Tian#, Ruo-Chen Guo#, Chunxia Wu, Xin Liu, Zeyu Zhang, Yamei Wang, Hao Wang, Gongyu Li, and Zhilin Yu*. Assembly of Glycopeptides in Living Cells Resembling Viral Infection for Cargo Delivery. Angew. Chem. Int. Ed. 2024, e202404703.


Ninglin Chen#, Zeyu Zhang#, Xin Liu, Hongbo Wang, Ruo-Chen Guo, Hao Wang, Binbin Hu, Yang Shi*, Peng Zhang*, Zhonghua Liu, Zhilin Yu*. Sulfatase-Induced In Situ Formulation of Antineoplastic Supra-PROTACs. J. Am. Chem. Soc. 2024, 146, 10753-10766.


Xiaowei Mo, Jinyan Song, Xin Liu, Ruo-Chen Guo, Binbin Hu, and Zhilin Yu*. Redox-Regulated In Situ Seed-Induced Assembly of Peptides. Biomicromolecules, 2024, 25, 2497-2508. Published as part of Biomacromolecules virtual special issue "Peptide Materials".


Xiaowei Mo, Zeyu Zhang, Jinyan Song, Yushi Wang, and Zhilin Yu*. Self-Assembly of Peptides in Living Cells for Disease Theranostics. J. Mater. Chem. B 2024, DOI: 10.1039/D4TB00365A. Invited Reviews for the themed collection "Stimuli Responsive Materials for Biomedical Applications".



2023年

Hao Wang#, Yanqiu Song#, Weishu Wang, Ninglin Chen, Binbin Hu, Xin Liu, Zeyu Zhang, and Zhilin Yu.* Organelle-Mediated Dissipative Self-Assembly of Peptides in Living Cells. J. Am. Chem. Soc. 2024, 146, 330-341.


Ruo-Chen Guo, Ning Wang, Weishu Wang, Zeyu Zhang, Wendi Luo, Yushi Wang, Haiqin Du, Yifei Xu, Gongyu Li,* and Zhilin Yu.* Artificial Peptide-Protein Necrosomes Promote Cell Death. Angew. Chem. Int. Ed. 2023, 62, e202314578.


Na Song, Zhe Sun, Bo Wang, Xin Liu, Binbin Hu, Sihe Zhang,* and Zhilin Yu.* Suicide Gene Delivery by Morphology-Adaptable Enantiomeric Peptide Assemblies for Combined Ovarian Cancer Therapy. Acta Biomaterialia 2023, In Press. DOI: 10.1016/j.actbio.2023.12.020.


Jinyan Song, Xiaowei Mo, Xin Liu, Binbin Hu, Zeyu Zhang, and Zhilin Yu.* Arginine Methylation Regulates Self-Assembly of Peptides. Macromol. Rapid Commun. 2023, 44, 2300308.



2022年

Yanqiu Song, Mingming Li, Na Song, Xin Liu, Guangyao Wu, Hao Zhou, Jiafu Long, Linqi Shi, and Zhilin Yu.* Self-Amplifying Assembly of Peptides in Macrophages for Enhanced Inflammatory Treatment. J. Am. Chem. Soc. 2022, 144, 6907–6917.


Xin Liu#, Mingming Li#, Juanzu Liu, Yanqiu Song, Binbin Hu, Chunxia Wu, An-An Liu, Hao Zhou, Jiafu Long, Linqi Shi, and Zhilin Yu.* In Situ Self-Sorting Peptide Assemblies in Living Cells for Simultaneous Organelle-Targeting. J. Am. Chem. Soc. 2022, 144, 9312-9323.


Xiunan Yu,# Hao Wang,# Xin Liu, Le Huang, Na Song, Yanqiu Song, Xiaowei Mo, Shaofeng Lou, Linqi Shi, and Zhilin Yu.* Assembling Synergistic Peptide-Drug Conjugates for Dual-Targeted Treatment of Cancer Metastasis. Nano Today, 2022, 46, 101594.


Na Song, Yanqiu Song, Binbin Hu, Xin Liu, Xiunan Yu, Hao Zhou, Jiafu Long, Zhilin Yu.* Persistent Endoplasmic Reticulum Stress Stimulated by Peptide Assemblies for Sensitizing Cancer Chemotherapy. Adv. Healthcare Mater. 2023, 12, 2202039.


Yanqiu Song, Zeyu Zhang, Yawei Cao, and Zhilin Yu.* Stimulus-Responsive Amino Acids Behind In Situ Assembled Bioactive Peptide Materials. ChemBioChem 2022, e202200497. Invited Reviews for the special Collection of ChemBioTalents2022.


Peng Zhang,* Saizhi Wu,# Jinting Li,# Xiaoshuang Bu,# Xiaoping Dong, Ninglin Chen, Fengjiao Li, Jingyu Zhu, Longkang Sang, Youlin Zeng, Songping Liang, Zhilin Yu,* Zhonghua Liu.* Dual-sensitive Antibacterial Peptide Nanoparticles Prevent Dental Caries. Theranostics 2022, 12, 4818-4833.


Mian Tang, Yanqiu Song, Yi-Lin Lu, Ying-Ming Zhang,* Zhilin Yu, Xiufang Xu, and Yu Liu.* Cyclodextrin-Activated Porphyrin Photosensitization for Boosting Self-Cleavable Drug Release. J. Med. Chem. 2022, 65, 6764-6774.



Yanqiu Song, Qi Su, Huijuan Song, Xiaoguang Shi, Mingming Li, Na Song, Shaofeng Lou, Weiwei Wang,* and Zhilin Yu.* Precisely Shaped Self-Adjuvanting Peptide Vaccines with Enhanced Immune Responses for HPV-Associated Cancer Therapy. ACS. Appl. Mater. Interfaces. 2021, 13, 49737-49753.



    2020年

    Zhifei Cheng,# Yuanyuan Cheng,# Qian Chen, Mingming Li, Jie Wang, Hui Liu, Mengwen Li, Yashan Ning, Zhilin Yu,* Yinsong Wang,* Hao Wang.* Self-assembly of pentapeptides into morphology-adaptable nanomedicines for enhanced combinatorial chemo-photodynamic therapyNano Today 202033, 100878.


    Shuxin Song, Jingyu Wang,* Zhifei Cheng, Zhimou Yang,  Linqi Shi, Zhilin Yu.* Directional molecular sliding movement in peptide hydrogels accelerates cell proliferation. Chemical Science 2020, 11, 1383-1393.


    Shuxin Song, Jingyu Wang, Na Song, Huixia Di, Dingbin Liu, Zhilin Yu.* Peptide interdigitation-induced twisted nanoribbons as chiral scaffolds for supramolecular nanozymesNanoscale 202012, 2422-2433.


    Binbin Hu, Zhengwen Lian, Zhifei Zhou, Linqi Shi, Zhilin Yu.* Reactive Oxygen Species-Responsive Adaptable Self-Assembly of Peptides toward Advanced BiomaterialsACS Applied Bio Materials 20203, 5529-5551.


    Zhifei Cheng,# Shanshan Nai,# Shuxin Song, Lingyi Chen,* Zhilin Yu.* Photoinduced directional domain sliding motion in peptide hydrogels promotes ectodermal differentiation of embryonic stem cellsScience China Materials 202063, 467–478.



    2019年

    Mingming Li,# Yashan Ning,# Jialiang Chen, Xingchen Duan, Na Song, Dan Ding,* Xuncheng Su,* Zhilin Yu.* Proline Isomerization-Regulated Tumor Microenvironment-Adaptable Self-Assembly of Peptides for Enhanced Therapeutic EfficacyNano Letters 201919, 7965-7976.


    Shaofeng Lou, Xinmou Wang, Zhilin Yu,* Linqi Shi.* Peptide Tectonics: Encoded Structural Complementarity Dictates Programmable Self‐AssemblyAdvanced Science 20196, 1802043.


    Huiru Zhang, Shaofeng Lou, Zhilin Yu.* Polar−π Interactions Promote Self-assembly of Dipeptides into Laminated NanofibersLangmuir 201935, 4710-4717.


    Mingming Li, Xinran Zhao, Jianfang Dai, Zhilin Yu.* Peptide therapeutics and assemblies for cancer immunotherapy. Science China Materials 201962, 1759-1781.



    2017年

    Zhilin Yu,# Aykut Erbas,# Faifan Tantakitti, Liam C. Palmer, Joshua A. Jackman, Monica Olvera de la Cruz,* Nam-Joon Cho,* Samuel I. Stupp.* Co-Assembly of Peptide Amphiphiles and Lipids into Supramolecular Nanostructures Driven by Anion-π Interactions. J. Am. Chem. Soc. 2017, 139, 7823-7830.


    Lee, S. S.; Fyrner, T.; Chen, F.; Álvarez, Z.; Sleep, E.; Chun, D. S.; Weiner, J. A.; Cook, R. W.; Freshman, R. D.; Schallmo, M. S.; Katchko, K. M.; Schneider, A. D.; Smith, J. T.; Yun, C.; Singh, G.; Hashmi, S. Z.; McClendon, M. T.; Yu, Z.; Stock, S. R.; Hsu, W. K.; Hsu, E. L.; Stupp, S. I.* Sulfated glycopeptide nanostructures for multipotent protein activation. Nature Nanotechnology 201712, 821-829.


    2016年

    Zhilin Yu, Faifan Tantakitti, Tao Yu, Liam C. Palmer, George Schatz, Samuel I. Stupp.* Simultaneous Covalent and Non-Covalent Hybrid Polymerizations. Science, 2016351, 497-502.


    Zhilin Yu, Faifan Tantakitti, Liam C. Palmer, Samuel I. Stupp.* Asymmetric Peptide Nanoribbons. Nano Letters 2016, 16, 6967-6974.


    Sabrina Steinwand, Zhilin Yu, Stefan Hecht,* Josef Wachtveitl.* Ultrafast dynamics of the photoisomerization and Subsequent Unfolding of an Oligo-azobenzene Foldamer. J. Am. Chem. Soc. 2016, 138, 12997-13005.


    Zhilin Yu, Stefan Hecht.* Remote Control Over Folding by Light. Chemical Communication 201652, 6639-6653.


    2015年

    Zhilin Yu, Stefan Hecht.* Influence of Linkage Chemistry on Folding, Self-Assembly, and Photoresponse of Amphiphilic Azobenzene Main Chain Polymers. J. Polym. Sci. A Polym Chem 201553, 313-318.


    2013年

    Zhilin Yu, Stefan Hecht.* Control over Unfolding Pathways by Localizing Photoisomerization Events within Heterosequence Oligoazobenzene Foldamers. Angew. Chem. Int. Ed. 201352, 13740-13744. 


    Zhilin Yu, Steffen Weidner, Thomas Risse,* Stefan Hecht.* The Role of Statistics and Microenvironment for The Photoresponse in Multi-Switch Architectures: The Case of Photoswitchable Oligoazobenzene Foldamers. Chemical Science 20134, 4156-4167.


    Sérgio R. Domingos, Steven J. Roeters, Saeed Amirjalayer, Zhilin Yu, Stefan Hecht,* Sander Woutersen*. Elucidating the backbone conformation of photoswitchable foldamers using vibrational circular dichroism. Phys. Chem. Chem. Phys. 201315, 17263-17267.


    2012年

    Zhilin Yu, Stefan Hecht.* Cooperative Switching Events in Azobenzene Foldamer Denaturation. Chem. Eur. J. 201218, 10519-10524.


    2011年

    Zhilin Yu, Stefan Hecht.* Reversible and Quantitative Denaturation of Amphiphilic Oligo(azobenzene) Foldamers. Angew. Chem. Int. Ed. 2011, 50, 1640-1643.


    David Bléger,* Zhilin Yu, Stefan Hecht,* Toward optomechanics: Maximizing the photodeformation of individual molecules. Chemical Communication 201147, 12260-12266.


    2008年

    Yu Liu,* Zhilin Yu, Yingming Zhang, Dongsheng Guo, Yuping Liu, Supramolecular Architectures of beta-Cyclodextrin-Modified Chitosan and Pyrene Derivatives Mediated by Carbon Nanotubes and their DNA Condensation. J. Am. Chem. Soc. 2008130, 10431-10439.


    Peng Liang, Hengyi Zhang, Zhilin Yu, Yu Liu,* Solvent-Controlled Photoinduced Electron Transfer between Porphyrin and Carbon Nanotubes. J. Org. Chem. 200873, 2163-2168.