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成果及论文

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34. Wenqi Gong, Deming Zhao, Feihong Chen*, Jian Zhao*, Jingjing Bu, Zhiyuan Zhou, Shaohua Gou*, Gang Xu*, Near-infrared-triggered Dibenzo[a,c][1,2,5]thiadiazolo[3,4-i]phenazine heterocyclic derivatives for type-I photodynamic and photothermal therapy against human nasopharyngeal carcinoma. Dyes Pigments 2024, 226, 112133.

          



33. Lei Fang, Rong Huang, Wenqi Gong, Yuanhui Ji, Yanyan Sun, Shaohua Gou*, Jian Zhao*, A self-assembly-induced exciton delocalization strategy for converting a perylene diimide derivative from a type-II to type-I photosensitizer. Small  2024, 20, 2307414


32. Yuliang Yang, Ya Gao, Jian Zhao*, Shaohua Gou*, A electron-accepting half-sandwich iridium(III) complex for the treatment of hypoxic tumors via  synergetic chemo- and phototherapy. Inorg. Chem. Front. 2024, 11, 436-450.



31. Yuliang Yang, Ya Gao, Yanyan Sun, Jian Zhao*, Shaohua Gou*, Study on the multimodal anticancer mechanism of Ru(II)/Ir(III) complexes bearing a poly(ADP-ribose)polymerase 1 inhibitor. J. Med. Chem. 2023,  66, 13731-13745.


30. Yuliang Yang, Xiaofeng Zou, Yanyan Sun, Feihong Chen, Jian Zhao*, Shaohua Gou*, Naphthalene diimides functionalized half-sandwich Ru(II) complexes as mitochondria-targeted anticancer and antimetastatic agents. Inorg. Chem. 2023, 62, 9649-9660.



29. Jian Zhao, Rong Huang, Ya Gao, Jiadong Xu, Yanyan Sun, Jiayuan Bao, Lei Fang*, Shaohua Gou*, Realizing NIR-triggered Type-I PDT and PTT via maximizing electronic exchange energy of perylene diimide-based photosensitizers. ACS Materials Lett. 2023, 5, 1752-1759.



28. Mengzhu Wang, Nan He, Runze Tang, Feiyang Li, Shujuan Liu, Feng Xu, Jian Zhao,* Yi Tong,* Qiang Zhao*, Rational design of Ru(II) complex with donor-acceptor-donor structure for organic resistive memory devices. Dalton. Trans. 2023, 52, 7620-7625.



27. Jian Zhao, Ya Gao, Rong Huang, Chen Chi, Yanyan Sun, Gang Xu,* Xing-Hua Xia,* Shaohua Gou*, Design of near-infrared-triggered metallo-photosensitizers via a self-assembly-induced vibronic decoupling strategy. J. Am. Chem. Soc. 2023, 145, 11633-11642.


26. Jian Zhao*,#, Ya Gao#, Weiyu He, Wei Wang, Weiwei Hu*, Yanyan Sun* Synthesis, characterization and biological evaluation of two cyclometalated iridium(III) complexes containing a glutathione S-transferase inhibitor. J. Inorg. Biochem. 2023, 238, 112050.


 25. Gang Xu, Chengwei Li, Chen Chi, Luyan Wu, Yanyan Sun, Jian Zhao*, Xing-Hua Xia*, Shaohua Gou*. A Supramolecular Photosensitizer Derived from an Arene-Ru(II) Complex Self-assembly for NIR Activated Photodynamic and Photothermal Therapy. Nat. Comm. 2022, 13, 3064..



24. Zhimei Wang, Chengwei Li , Shuyan Huang, Xiangde Ma, Yanyan Sun, Jian Zhao*, Shaohua Gou*, Boosting Phototherapy Efficacy of a NIR-Absorbing Ruthenium (II) Complex via Supramolecular Engineering. Materials Today Nano. 2022, 100220.


23. Chengwei Li, Ya Gao, Rong Huang, Lei Fang,*, Yanyan Sun, Yuliang Yang, Shaohua Gou*, Jian Zhao*, An Effective Supramolecular Approach to Boost the Photodynamic Therapy Efficacy of a Near-Infrared Activating Perylene Diimide-Based Photosensitizer. ACS Materials. Lett. 2022, 4, 657-664.


22. Bin Zhang, Zichen Xu, Wen Zhou, Zhikun Liu, Jian Zhao*, Shaohua Gou*. A light-controlled multi-step drug release nanosystem targetingtumor hypoxia for synergistic cancer therapy. Chem. Sci.202112, 11810-11820.


21. Jian Zhao, Kaiwen Yan, Gang Xu, Xue Liu, Qiang Zhao*, Chenjie Xu*, Shaohua Gou*.  An Iridium(III) Complex Bearing a Donor- Acceptor-Donor Type Ligand for NIR-Triggered Dual Phototherapy. Adv. Funct. Mater. 2021, 31, 2008325.


20.  Wuyang Hua, Gang Xu, Jian Zhao*, Jiapeng Lu, Wenfang Sun*, Shaohua Gou*. DNA Targeting Ru(II)Polypyridyl Complex with LongLived 3IL Excited State as potential photodynamic therapy agent. Chem. Eur. J. 2020, 26, 17495 -17503.


19.  Shuang Li, Jian Zhao*, Xinyi Wang, Gang Xu, Shaohua Gou*, Qiang Zhao*. Design of a Tris-Heteroleptic Ru(II) Complex with Red-Light Excitation and Remarkably Improved Photobiological Activity. Inorg. Chem., 2020, 59, 11193-11204.


18.  Shuang Li, Gang Xu, Yuhua Zhu, Jian Zhao*, Shaohua Gou*. Bifunctional ruthenium(II) polypyridyl complexes of curcumin as potential anticancer agents. Dalton Trans., 2020, 49, 9454-9463. 


17. Jian Zhao, Xinzhong Zhang, Lei Fang*, Chuanzhu Gao, Chenji Xu*, Shaohua Gou*. Iridium(III) complex–derived polymeric micelles with low dark toxicity and strong NIR excitation for phototherapy and chemotherapy. Small, 2020, 16, 2000363.


16. Zhimei Wang, Lei Fang, Jian Zhao *, Shaohua Gou *, Insight into the antitumor actions of sterically hindered platinum(II) complexes by a combination of STD NMR and LCMS techniques. Metallomics, 2020, 12, 427-434.


15. Jian Zhao, Sun Shuchen, Li Xiaoyan, Zhang Wenjing*, Gou Shaohua*, Enhancing photodynamic therapy efficacy of upconversion-based nanoparticles conjugated with a long-lived triplet excited state iridium(III)-naphthalimide complex: toward highly enhanced hypoxia-inducible factor‑1. ACS Appl. Bio Mater., 2020, 3, 252-262.


14. Jian Zhao, Shuang Li, Xinyi Wang, Gang Xu, Shaohua Gou*. Dinuclear Organoruthenium Complexes Exhibit Antiproliferative Activity through DNA Damage and ROS-mediated ER Stress Pathway. Inorg. Chem., 2019, 58, 2208-2217.


13. Jian Zhao, Suchen Sun, Shaohua Gou*, Xinyi Wang, Zhimei Wang, Xiaoyan Li, Wenjing Zhang*, Light-activated ruthenium (II)-bicalutamide prodrugs for prostate cancer. J. Inorg. Biochem., 2019, 196, 110684.

12.  Jian Zhao, Dingyi Zhang, Wuyang Hua, Wanchun Li, Gang Xu, Shaohua Gou*. Anticancer Activity of Bifunctional Organometallic Ru(II) Arene Complexes Containing a 7‑Hydroxycoumarin Group. Organometallics., 2018, 37, 441-447.

11. Jian Zhao, Wanchun Li, Shaohua Gou*, Shuang Li, Shengqiu Lin, Qianhui Wei, Gang Xu*. Hypoxia-targeting oganometallic Ru(II)-arene complexes with enhanced anticancer activity in hypoxic cancer cells. Inorg. Chem., 2018, 57, 8396-8403.

10.  Jian Zhao, Zhichen Xu, Jing Lin, Shaohua Gou*. Exploring the Hydrolytic Behavior of the Platinum(IV) Complexes with Axial Acetato Ligands. Inorg. Chem., 2017, 56, 9851-9859.

9.  Yanyan Sun*, Jian Zhao*, Zhongling Ji. Bifunctional Platinum(II) Complexes with Bisphosphonates Substituted Diamine Derivatives: Synthesis and In vitro Cytotoxicity. Chem. Biodiversity., 2017, 14, e1700348.

8. Jian Zhao, Wuyang Hua, Gang Xu, Shaohua, Gou*. Biotinylated platinum(IV) complexes designed to target cancer cells. J. Inorg. Biochem., 2017, 176, 175-180.

7. Jian Zhao, Dan Wang, Gang Xu, Shaohua Gou*. Improve the anticancer potency of the platinum(II) complexes through functionalized leaving group. J. Inorg. Biochem., 2017, 175, 20-28.

6.  Jian Zhao, Kathleen E. Prosser, Stephanie W. Chang, Shradha P. Zakharia, Charles J. Walsby*. Combining a Ru(II)-arene complex with a NO-releasing nitrate-ester ligand generates cytotoxic activity. Dalton Trans., 2016, 45, 18079-18083.

5.  Jian Zhao, Shaohua Gou*, Fengfan Liu. Potent anticancer activity and possible low toxicity of platinum(II) complexes with functionalized 1,1-Cyclobutanedicarboxylate as a leaving ligand. Chem. Eur. J. 2014, 20, 15216-15225.

4. Jian Zhao, Shaohua Gou*, Gang Xu, Lin Cheng. Antitumor platinum(II) complexes of N-monoalkyl 1R,2R-diaminocyclohexanes with 3-(nitrooxy)cyclobutane-1,1-dicarboxylate as a leaving group. Eur. J. Med. Chem. 2014, 85, 408-417.

3. Jian Zhao, Shaohua Gou, Yanyan Sun, Lei Fang, Zhimei Wang. Antitumor platinum(II) complexes containing platinum-based moieties of present platinum drugs and furoxan groups as nitric oxide donors: synthesis, DNA interaction, and cytotoxicity. Inorg. Chem.2012, 51, 10317-10324. 

2. Jian Zhao, Shaohua Gou, Fei Liu, Yanyan Sun, Chuanzhu Gao. Anticancer potency of platinum(II) complexes containing both chloride anion and chelated carboxylate as leaving groups. Inorg. Chem., 2013, 52, 8163-8170. 

1. Jian Zhao, Shaohua Gou, Yanyan Sun, Runting Yin, Zhimei Wang, Nitric oxide donor-based platinum complexes as potential anticancer agents. Chem. Eur. J., 2012, 18, 14276-14281. 




 专利

 [1] 赵健; 许正; 一种甘露糖靶向的热响应铂纳米颗粒及其制备方法和应用, 2019-12-5, 中国, 申请号:201911235752.5.

 [2] 赵健; 一种以姜黄素衍生物为配体的钌(II)配合物及其制备方法和应用, 2019-6-10, 中国, 申请号:201910496257.3.

 [3] 赵健; 一种芳烃-钌配合物及其制备方法和应用, 2018-04-11, 中国, 授权号:108440601 B. 

 

 奖项

    1、东南大学青年教师授课竞赛三等奖,2018年。

    2、入选东南大学至善青年学者2019~至今

    3、第六届卓越联盟大学生化学新实验设计竞赛,二等奖,指导教师排名1/22019年。

    42019年国家级SRTP项目指导教师

    52018年江苏省教育教学与研究成果奖(研究类)二等奖 4/6