科研项目
1.赵轶男(赵轶男，甄宇红，赵恒，鄂爽), 肽脂质调控mRNA-LNP精细结构增强稳定性研究(22578054), 国家自然科学基金面上项目, 2026.01-2029.12, 50万元
2.邹杨, 乏氧激活光动力治疗和化疗协同抗肿瘤前药的构建及协同机制研究(22408043), 国家自然科学基金青年项目, 2025.01-2027.12, 30万
3.鄂爽, 内质网靶向红光/近红外碳点荧光探针精准构建及其肝癌早期成像研究(2404015), 国家自然科学基金青年项目, 2025.01-2027.12, 30万
4.赵轶男, 螺虫乙酯类农药原料中间体研发, 阜新睿光氟化学有限公司, 大连民族大学, 30万
5.张令娥, 树枝状大分子高效靶向递释烟草活性物质用于AD治疗研究, 北京生命科技研究院有限公司(重点实验室), 20万
6.张树彪,(张树彪，郭术涛，刘宇，赵轶男、支德福、宣扬、张令娥), 基于肽脂质高通量合成平台的肺癌靶向mRNA-LNP创制及抗肿瘤研究(U23A20488), 国家自然科学基金委, 区域创新联合基金项目, 2024.01-2027.12, 260万
7.张树彪, (张树彪, 赵轶男, 陈会英, 李代, 甄宇红, 支德福, 韩玲钰, 宣扬, 鄂爽, 田可欣, 马婉婷, 符星星, 石健), 大连市科技创新基金重大基础研究,壳聚糖递送载体的构建及其海洋生物制品研发(2023JJ11CG007), 2024.01-2026.12, 100万
8.支德福, (张树彪, 李福, 江殿平, 赵轶男, 崔韶晖, 陈会英, 石健, 张文亮) 药物/基因复合型可溶性微针的创制及应用(2023RJ005), 大连市科学技术局, 大连市杰出青年支持计划, 2024.1.1-2026.10.31, 100万
9.赵轶男, (张树彪，郭术涛(南开), 刘娜(沈阳疾病防治中心 ), 支德福, 周泉, 宣扬, 鄂爽, 高召) 多级mRNA脂质纳米粒构建及抗肿瘤研究,辽宁省科技计划联合计划(重点研发计划项目2023JH2/101800011), 2023.12.01-2025.11.30, 100万
代表性期刊论文(近五年）
1.Xu Zhang*, Ying Chen, Zhiqing Liu, Shuxian Song, Shiqiang Liu, Fengrui Liu, Xingchen Jin, Xinlei Ma, Yinfeng Zhang, Kai Zhang, Quan Zhou*, Anmin Liu*. Small and low-crystallinity NiO nanoparticles embedded in hollow carbon materials for high performance asymmetric supercapacitors, Journal of Energy Storage, 2025, 113: 115738.
2. Litao Hu, Huiling Ma, Chunpeng Yang, Kang Wang, Xu Ji, Tingxue Xu, Hong Xu, Yinan Zhao*, Yuhong Zhen*. Environmental responsive dual-drug synergistic and dual-targeted polymer micelles based on chondroitin sulfate for treatment of breast cancer. International Journal of Biological Macromolecules, 2025, 311, 144083.
3. Chunpeng Yang, Huiling Ma, Ze Liang, Ying Zhuang, Litao Hu, Kexin Zhang, Leixiao Huang, Min Li*, Shubiao Zhang*, Yuhong Zhen*. Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer. International Journal of Biological Macromolecules, 2025, 308, 142272.
4. Mengdi Wu, Jiabao Sheng, Qihan Xie, Yanfei Qi, Yinan Zhao*, Shubiao Zhang*. Recent advances in stimuli-responsive hyaluronic acid-based nanodelivery systems for cancer treatment: A Review. International Journal of Biological Macromolecules, 2025, 316: 144357.
5. Xinyue Shen, Donghui Zhao, Junyi Shi, Chaoqing Li, Yang Bai, Lin Qiu*, Yang Xuan*, Jianhao Wang*. Copper peroxide loaded gelatin/oxide dextran hydrogel with temperature and pH pesponsiveness for antibacterial and wound healing activity. International Journal of Biological Macromolecules, 2024, 274: 133258.
6. Donghui Zhao, Yunhao Deng, Junyi Shi, Xinye Ni, Chaoqing Li, Yang Bai, Yang Xuan*, Jianhao Wang*. Self-assembling gelatin based delivery of multienzyme activity nanozyme and photosensitizer for ROS storm based cancer therapy. International Journal of Biological Macromolecules, 2024, 276: 133963.
7. Yanzhi Xing, Jiaxin Li, Han Leng, Yanfeng Zhang, Shuang E, Jianhua Wang, Xuwei Chen. From cell membrane to endoplasmic reticulum: Tunable lipid membrane imaging by regulating the lipophilicity and internalization of carbon dots. Chemical Engineering Journal, 2024, 492: 152068.
8. Haijie He, Shuang E, Hongxia Qiao, Jie Yang, Caiyuan Lin, Chuang He, Peng Xu*. A general and simple method to disperse 2D nanomaterials for promoting cement hydration. Construction and Building Materials, 2024, 427: 136217.
9. Xin Tracy Liu, Yu Huang, Da Liu, Yingxin Celia Jiang, Min Zhao, Long Hoa Chung, Xingxing Daisy Han, Yinan Zhao, Jinbiao Chen, Paul Coleman, Ka Ka Ting, Collin Tran, Yingying Su, Claude Vincent Dennis, Atul Bhatnagar, Ken Liu, Anthony Simon Don, Mathew Alexander Vadas, Mark Douglas Gorrell, Shubiao Zhang, Michael Murray, Mary Meltem Kavurma, Geoffrey William McCaughan, Jennifer Ruth Gamble, Yanfei Qi. Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. Journal of Translational Medicine, 2024, 22: 43.
10. Guo Feng, Yu Yan, Mengfan Wang, Zhao Gao, Yinan Zhao, Xin Peng. The Inhibition Mechanisms of Three Structurally Different Salvianolic Acids on the Non-Enzymatic Glycation of Bovine Serum Albumin. Plant Foods for Human Nutrition. 2024, 79(2): 526-530
11.Xiao Chen*, Longwei Meng, Huiyu Fu, Quan Zhou*, Changhai Liang*. PtZn/ZnO intermetallic catalyst prepared by reactive metal-support interaction for the semi-hydrogenation of 1,4-butynediol, Applied catalysis A-general, 2024, 677: 119693.
12.Shuang E, YanZhi Xing, Sang Du, AnMin Liu, Zhao Gao, Quan Zhou, Yang Xuan, Yi Nan Zhao*, XuWei Chen*, ShuBiao Zhang*. Shape control of carbon nanoparticles via a simple anion-directed strategy for precise endoplasmic reticulum-targeted imaging. Angewandte Chemie International Edition, 2023, e202311008-e202311008.
13. Defu Zhi, Jian Shi, Shaohui Cui, Ting Yang, Jian Yang, Wei Wang, Pengfei Ma, Yuhong Zhen, Shubiao Zhang*. Biodegradable sucrose ester-based cationic lipids as novel vectors for efficient and safe delivery of IGF-1R siRNA. ACS Materials Lett. 2023, 5: 862-873.
14. Rui Wang, Yinan Zhao, Zhenlong Huang, Yaxin Zhou, Wei Wang, Yang Xuan, Yuhong Zhen, Benzhi Ju*, Shutao Guo*, and Shubiao Zhang*. Self-Assembly of Podophyllotoxin-Loaded Lipid Bilayer Nanoparticles for Highly Effective Chemotherapy and Immunotherapy via Downregulation of Programmed Cell Death Ligand 1 Production. ACS Nano, 2022, 16: 3943−3954.
15. Rui Wang, Yang Xuan, Yinan Zhao, Wei Wang, Pengfei Ma, Benzhi Ju*, Yuhong Zhen*, Shubiao Zhang*. Cationic Nanoparticulate System for Codelivery of MicroRNA-424 and Podophyllotoxin as a Multimodal Anticancer Therapy. Molecular Pharmaceutics, 2022, 19, (7): 2092–2104.42.Yinan Zhao, Tianyi Zhao, Yingnan Cao, Jiao Sun, Quan Zhou, Huiying Chen, Shutao Guo, Yifeng Wang, Yuhong Zhen, Xingjie Liang, Shubiao Zhang*. Temperature- Sensitive Lipid-Coated Carbon Nanotubes for Synergistic Photothermal Therapy and Gene Therapy. ACS Nano, 2021, 15 (4), 6517-6529.
16. Yang Xuan, Meng Guan, Shubiao Zhang*. Tumor Immunotherapy and Multi-Mode Therapies Mediated by Medical Imaging of Nanoprobes. Theranostics, 2021, 11 (15), 7360-7378.
17. Shuang Fu, Yinan Zhao, Jiao Sun,YTin gang, Defu Zhi, Enxia Zhang, Fangli Zhong,Yuhong Zhen, Shufen Zhang, Shubiao Zhang*. Integrin Alphavbeta3-Targeted Liposomal Drug Delivery System for Enhanced Lung Cancer Therapy. Colloids and Surfaces B-Biointerfaces, 2021, 201, 111623.
18. I Gusti Md Gde Surya C. Trapika, Xin Tracy Liu, Long Hoa Chung, Felcia Lai, Chanlu Xie, Yang Zhao, Shaohui Cui, Jinbiao Chen, Collin Tran, Qian Wang, Shubiao Zhang, Anthony S. Don, George Qian Li, Jane R. Hanrahan, Yanfei Qi. Ceramide Regulates Anti-Tumor Mechanisms of Erianin in Androgen-Sensitive and Castration-Resistant Prostate Cancers. Frontiers in Oncology, 2021,11, 738078. 2021.09.
19. Yinan Zhao, Tianyi Zhao, Yanyan Du, Yingnan Cao, Yang Xuan, Huiying Chen, Defu Zhi, Shutao Guo*, Fangli Zhong*, Shubiao Zhang*. Interaction Kinetics of Peptide Lipids‑Mediated Gene Delivery. Journal of Nanobiotechnology, 2020, 18(1): 144
20. Defu Zhi, Ting Yang, Jian Yang, Shuang Fu, Shubiao Zhang*. Targeting Strategies for SuperParamagnetic Iron Oxide Nanoparticles in Cancer Therapy. Acta Biomaterialia, 2020, 102: 13–34.
21. Chuanmin Zhang, Shubiao Zhang*, Defu Zhi, Yinan Zhao Shaohui Cui, Jingnan Cui. Co-Delivery of Paclitaxel and Survivin Sirna with Cationic Liposome for Lung Cancer Therapy - Sciencedirect. Colloids and Surfaces A, 2020, 585:1-9
22. Chuanmin Zhang,Yinan Zhao, Enxia Zhang ,Meilin Jiang, Defu Zhi, Huiying Chen, Shaohui Cui, Yuhong Zhen, Jingnan Cui, Shubiao Zhang*. Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the antitumor activity for lung cancer therapy. Drug Delivery 2020, 27: 1397-1411.
专著
Yinan Zhao, Defu Zhi, Shubiao Zhang (2011), Cationic liposomes in different structural levels for gene delivery, NON-VIRAL GENE THERAPY, InTech,
专利
1.张树彪, 鄂爽, 石健, 张令娥. 一种酸洗液制备方法, ZL202210564496.X, 2024.03.29. 中国发明专利
2.鄂爽, 张树彪, 石健, 赵轶男. 一种便捷制备含碳点缓蚀剂的酸洗液方法, ZL202210527209.8, 2024.03.22. 中国发明专利
3.张树彪, 鄂爽, 宣扬, 张令娥. 一步制备含碳点缓蚀剂的酸洗剂方法, ZL202210514247.X, 2024.03.22. 中国发明专利
4.鄂爽, 张树彪, 宣扬, 赵轶男. 一种原位制备含氮掺杂碳点缓蚀剂的酸洗剂方法, ZL202210566527.5, 2024.03.08. 中国发明专利
5.张树彪, 邹禹, 陈会英, 赵轶男, 林可心, 刘占彪. 一类含有多个酯键可电离叔胺脂质及其合成方法和应用, ZL202210374956.2, 2024.09.17. 中国发明专利
6.张树彪, 李敏, 赵轶男, 孙姣, 林可心, 刘占彪. 环境响应型透明质酸-鬼臼毒素前药胶束及其制备方法和应用, ZL 202111161507.1, 2023.10.31. 中国发明专利
7.张树彪, 陈会英, 范雪枫, 蓝浩铭, 崔韶晖. 靶向壳聚糖纳米银凝胶及其制备方法和应用, ZL 202010941932.1, 2023.04.28. 中国发明专利
8.张树彪, 孙姣, 赵轶男, 周泉, 许晓东, 张传敏. 一种葡聚糖-槲皮素前药聚合物的制备方法, ZL201910585119.2, 2022.11.08. 中国发明专利
9.张树彪, 陈会英, 范雪枫, 刘建波, 赵轶男. 吸收波长随温度振荡的光热转换材料及其制备方法和应用, ZL202010941924.7, 2022.9.16. 中国发明专利
10.张树彪, 陈会英, 蓝浩铭, 范雪枫, 马羽. 一种超支化聚壳多糖及其制备方法和应用, ZL201910272273.4, 2021.7.2. 中国发明专利
11.Shubiao Zhang, Yinan Zhao, Shaohui Cui, Huiying Chen, Quan Zhou. Bisalkoxyl amide alkyl, cationic peptide lipids, synthesis method thereof, and application thereof, US10597678B2, 2020.03.24. 美国发明专利
12.张树彪, 陈会英, 马羽, 秦晓利, 蓝浩铭, 崔韶晖. 氧化还原响应壳聚糖-脂质体的应用, ZL201711362846.X, 2020.10.16. 中国发明专利
13.Shubiao Zhang, Yinan Zhao, Shaohui Cui, Defu Zhi, Hua Hai. Propyl cationic peptide lipids,synthesis method thereof, and application thereof, US10294199B2, 2019.5. 美国发明专利
14.Shubiao Zhang, Defu Zhi, Shaohui Cui, Yinan Zhao, Quan Zhou. Sucrose ester-type cationic gene vector and preparation method thereof, US10279050B2, 2018.12.17. 美国发明专利
奖励
1.张树彪, 赵轶男, 支德福, 崔韶晖, 周泉, 陈会英, 宣扬. 新型脂质递送载体及其药物控释研究. 大连市自然科学二等奖, 2024年2月.
2.赵轶男, 张树彪, 支德福, 崔韶晖, 周泉. 蔗糖酯型药物载体研发及应用. 大连市科学进步三等奖, 2022年2月.
3.张树彪, 赵轶男, 支德福, 崔韶晖, 陈会英. 新型阳离子脂质及基因递送研究. 辽宁省自然科学二等奖, 2021年4月.
4.张树彪, 陈会英, 崔韶晖, 赵轶男, 支德福. 壳聚糖转染试剂制备关键技术. 大连市技术发明三等奖, 2020年6月.
5.赵轶男. Effects of sucrose ester structures on liposome-mediated gene delivery. 辽宁省自然科学学术成果三等奖, 2019年.