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成果及论文

张绪穆课题组代表性工作

(1) Liu Cao, Yingjun Li, Sidi Yang, Guanguan Li, Qifan Zhou, Jing Sun,Tiefeng Xu, Yang Yang, Ruyan Liao, Yongxia Shi, Yujian Yang, Tiaozhen Zhu, Siyao Huang, Yanxi Ji, Feng Cong, Yinzhu Luo, Yujun Zhu, Hemi Luan, Huan Zhang, Jingdiao Chen, Xue Liu, Renru Luo, Lihong Liu, Ping Wang, Yang Yu, Fan Xing, Bixia Ke, Huanying Zheng, Xiaoling Deng, Wenyong Zhang, Chuwen Lin, Mang Shi, ChunMei Li, Yu Zhang, Lu Zhang, Jun Dai, Hongzhou Lu, Jincun Zhao*, Xumu Zhang*, Deyin Guo*; The adenosine analogue prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants, Science Translational Medicine. (just accepted)

(2) L. a. Hu, Y.-Z. Wang, L. Xu, Q. Yin*, X. Zhang*, Highly Enantioselective Synthesis of N-Unprotected Unnatural α-Amino Acid Derivatives by Ruthenium-Catalyzed Direct Asymmetric Reductive Amination, Angew. Chem., Int. Ed. 2022, 61, e202202552.

(3) B. Lin, T. Yang, D. Zhang, Y. Zhou, L. Wu, J. Qiu, G.-Q. Chen*, C.-M. Che*, X. Zhang*, Gold-Catalyzed Desymmetric Lactonization of Alkynylmalonic Acids Enabled by Chiral Bifunctional P,N ligands, Angew. Chem., Int. Ed. 2022, 61, e202201739.

(4) Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.; Lu, Y.; Zhang, X. Concise, scalable and enantioselective total synthesis of prostaglandins, Nat. Chem. 2021, DOI: 10.1038/s41557-021-00706-1.

(5) Li, Y.; Cao, L.; Li, G.; Cong, F.; Li, Y.; Sun, J.; Luo, Y.; Chen, G.; Li, G.; Wang, P.; Xing, F.; Ji, Y.; Zhao, J.; Zhang, Y.; Guo, D.; Zhang, X., Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models, J. Med. Chem. 2021, DOI: 10.1021/acs.jmedchem.0c01929.

(6) Wang, F.; Yang, T.; Wu, T.; Zheng, L.-S.; Yin, C.; Shi, Y.; Ye, X.-Y.; Chen, G.-Q.; Zhang, X., Asymmetric Transfer Hydrogenation of alpha-Substituted-beta-Keto Carbonitriles via Dynamic Kinetic Resolution, J. Am. Chem. Soc. 2021, 143, 2477-2483. 

(7) Du, X.; Xiao, Y.; Yang, Y.; Duan, Y.-N.; Li, F.; Hu, Q.; Chung, L. W.; Chen, G.-Q.; Zhang, X., Enantioselective Hydrogenation of tetra-Substituted alpha,beta-Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights, Angew. Chem., Int. Ed. 2021, DOI: 10.1002/anie.202016705.

(8) Yang, T.; Sun, Y.; Wang, H.; Lin, Z.; Wen, J.; Zhang, X., Iridium-Catalyzed Enantioselective Hydrogenation of Oxocarbenium Ions: A Case of Ionic Hydrogenation, Angew. Chem. 2020, 59, 6108-6114. 

(9) Hu, L. A.; Zhang, Y.; Zhang, Q. W.; Yin, Q.; Zhang, X., Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2, Angew. Chem. 2020, 59, 5321-5325.

(10) Du, X.; Xiao, Y.; Huang, J.-M.; Zhang, Y.; Duan, Y.-N.; Wang, H.; Shi, C.; Chen, G.-Q.; Zhang, X., Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids, Nat. Commun. 2020, 11, 3239.