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成果及论文

张绪穆课题组代表性工作

(1) Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.; Lu, Y.; Zhang, X. Concise, scalable and enantioselective total synthesis of prostaglandins, Nat. Chem. 2021, in press

(2) Li, Y.; Cao, L.; Li, G.; Cong, F.; Li, Y.; Sun, J.; Luo, Y.; Chen, G.; Li, G.; Wang, P.; Xing, F.; Ji, Y.; Zhao, J.; Zhang, Y.; Guo, D.; Zhang, X., Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models, J. Med. Chem. 2021, DOI: 10.1021/acs.jmedchem.0c01929.

(3) Wang, F.; Yang, T.; Wu, T.; Zheng, L.-S.; Yin, C.; Shi, Y.; Ye, X.-Y.; Chen, G.-Q.; Zhang, X., Asymmetric Transfer Hydrogenation of alpha-Substituted-beta-Keto Carbonitriles via Dynamic Kinetic Resolution, J. Am. Chem. Soc. 2021, 143, 2477-2483; (4) Du, X.; Xiao, Y.; Yang, Y.; Duan, Y.-N.; Li, F.; Hu, Q.; Chung, L. W.; Chen, G.-Q.; Zhang, X., Enantioselective Hydrogenation of tetra-Substituted alpha,beta-Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights, Angew. Chem., Int. Ed. 2021, DOI: 10.1002/anie.202016705

(5) Yang, T.; Sun, Y.; Wang, H.; Lin, Z.; Wen, J.; Zhang, X., Iridium-Catalyzed Enantioselective Hydrogenation of Oxocarbenium Ions: A Case of Ionic Hydrogenation, Angew. Chem. 2020, 59, 6108-6114; 

(6) Hu, L. A.; Zhang, Y.; Zhang, Q. W.; Yin, Q.; Zhang, X., Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2, Angew. Chem. 2020, 59, 5321-5325; 

(7) Du, X.; Xiao, Y.; Huang, J.-M.; Zhang, Y.; Duan, Y.-N.; Wang, H.; Shi, C.; Chen, G.-Q.; Zhang, X., Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids, Nat. Commun. 2020, 11, 3239; 

(8) Chen, G.-Q.; Huang, J.-M.; Lin, B.-J.; Shi, C.; Zhao, L.-Y.; Ma, B.-D.; Ding, X.-B.; Yin, Q.; Zhang, X., Highly Enantioselective Hydrogenation of tetra- and tri-Substituted Unsaturated Carboxylic Acids with oxa-Spiro Diphosphine Ligands, CCS Chemistry 2020, 2, 468-477; 

(9) You, C.; Li, X.; Gong, Q.; Wen, J.; Zhang, X., Nickel-Catalyzed Desymmetric Hydrogenation of Cyclohexadienones: An Efficient Approach to All-Carbon Quaternary Stereocenters, J. Am. Chem. Soc. 2019, 141, 14560-14564; 

(10) Li, X.; You, C.; Yang, J.; Li, S.; Zhang, D.; Lv, H.; Zhang, X., Asymmetric Hydrocyanation of Alkenes without HCN, Angew. Chem., Int. Ed. 2019, 58, 10928-10931; 

(11) Duan, Y.-N.; Du, X.; Cui, Z.; Zeng, Y.; Liu, Y.; Yang, T.; Wen, J.; Zhang, X., Homogeneous hydrogenation with a cobalt/tetraphosphine catalyst: a superior hydride donor for polar double bonds and N-heteroarenes, J. Am. Chem. Soc. 2019, 141, 20424-20433;

(12) Deng, X.; Shi, L. Y.; Lan, J.; Guan, Y. Q.; Zhang, X.; Lv, H.; Chung, L. W.; Zhang, X., Enantioselective Rhodium-Catalyzed Cycloisomerization of 1,6-Allenynes to access 5/6-Fused Bicycle[4.3.0]nonadienes, Nat Commun 2019, 10, 949.