张绪穆课题组代表性工作

1. Zong, Y.; Zhang, R.; Ma, B.; Peng, J.; Wu, C.; Zou, X.; Qian Y.; Chen, G.; Zhang, X., Robust, Scalable and Highly Selective Spirocyclic Catalyst for Industrial Hydroformylation and Isomerization-Hydroformylation. Science Advances

2. Zhou, Q.; Yang, S.; Cao, L.; Yang, Y.; Xu, T.; Chen, Q.; Lu, H.; Li, Y.; Guo, D.; Zhang, X., Preclinical characterization and anti-SARS-CoV-2 efficacy of ATV014: an oral cyclohexanecarboxylate prodrug of 1′-CN-4-aza-7,9-dideazaadenosine C-nucleoside, Signal Transduction and Targeted Therapy. 2023, 8, 27. https://doi.org/10.1038/s41392-023-01310-0.

3. Yang, L.; Yang, T.; Qian, Y.; Zhang, X.; Wen, J., Desymmetric Hydrogenation of meso-Dicarboxylic Acids. J. Am. Chem. Soc.2023, 146(23), 15908-15916.

4. Yang, Y.; Cao, L.; Yan, M.; Zhou, J.; Yang, S.; Xu, T.; Huang, S.; Li, K.; Zhou, Q.; Li, G. J. A. R., Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2. Antiviral Research. 2023, 213, 105586.

5. Zhou, Q.; Luo, Y.; Zhu, Y.; Chen, Q.; Qiu, J.; Cong, F.; Li, Y.; Zhang, X., Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses. European Journal of Medicinal Chemistry. 2023, 249, 115113.

6. Guan, F.; Qian, Y.; Zhang, P.; Zhang, R.; Zhang, X.; Wen, J. J. A. C., Fast Isomerization Before Isomerization‐Hydroformylation: Probing the Neglected Period with A Novel Microfluidic Device. Angew. Chem. Int. Ed. 2023, 62, e202302777.

7. Wang, J.; Shi, Y.; Wang, F.; Huang, F.; Bai, S.; Zhao, Y.; Zhang, X. J. A. C., Concise Synthesis of Chiral Tricyclic Lactams by Tandem Dynamic Kinetic Asymmetric Reductive Amination/Lactamization Using Ammonium Salts. Angew. Chem. Int. Ed. 2023, 62, e202303868.

8. Yin, C.; Jiang, Y.-F.; Huang, F.; Xu, C.-Q.; Pan, Y.; Gao, S.; Chen, G.-Q.; Ding, X.; Bai, S.-T.; Lang, Q. J. N. C., A 13-million turnover-number anionic Ir-catalyst for a selective industrial route to chiral nicotine. Nature Communications. 2023, 14, 3718.

9. Wang, F.; Zhang, Z.; Chen, Y.; Ratovelomanana-Vidal, V.; Yu, P.; Chen, G.-Q.; Zhang, X. J. N. C., Stereodivergent synthesis of chiral succinimides via Rh-catalyzed asymmetric transfer hydrogenation. Nature Communications. 2022, 13 , 7794.

10. Wang, F.; Chen, Y.; Yu, P.; Chen, G.-Q.; Zhang, X., Asymmetric Hydrogenation of Oximes Synergistically Assisted by Lewis and Brønsted Acids, J. Am. Chem. Soc. 2022, 144, 17763-17768.

11. Cao, L.; Yang, S.; Xu, T.; Huang, S.; Ji, Y.; Liu, X.; Luo, R.; Liu, L.; Xing, F.; Lin, C.; Shi, M.; Li, C.-M.; Guo, D.; Li, Y.; Li, G.; Zhou, Q.; Yang, Y.; Zhu, T.; Yu, Y.; Zhang, X.; Li, G.; Wang, P.; Zhang, X.; Sun, J.; Zhao, J.; Yang, Y.; Lu, H.; Liao, R.; Shi, Y.; Zhang, L.; Dai, J.; Cong, F.; Luo, Y.; Zhu, Y.; Zhang, Y.; Luan, H.; Zhang, W.; Zhang, H.; Chen, J.; Ke, B.; Zheng, H.; Deng, X.; Zhao, J.; Guo, D., The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants, Sci. Transl. Med. 2022, 14, eabm7621.

12. Li, S.; Zhang, D.; Zhang, R.; Bai, S.-T.; Zhang, X., Rhodium-Catalyzed Chemo-, Regio- and Enantioselective Hydroformylation of Cyclopropyl-Functionalized Trisubstituted Alkenes, Angew. Chem., Int. Ed. 2022, 61, e202206577.

13. Lin, B.; Yang, T.; Zhang, D.; Zhou, Y.; Wu, L.; Qiu, J.; Chen, G.-Q.; Che, C.-M.; Zhang, X., Gold-Catalyzed Desymmetric Lactonization of Alkynylmalonic Acids Enabled by Chiral Bifunctional P,N ligands, Angew. Chem., Int. Ed. 2022, 61, e202201739.

14. Li, Y.; Cao, L.; Li, G.; Cong, F.; Li, Y.; Sun, J.; Luo, Y.; Chen, G.; Li, G.; Wang, P.; Xing, F.; Ji, Y.; Zhao, J.; Zhang, Y.; Guo, D.; Zhang, X., Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models, J. Med. Chem. 2022, 65, 2785-2793.

15. Hu, L. a.; Wang, Y.-Z.; Xu, L.; Yin, Q.; Zhang, X., Highly enantioselective synthesis of N-unprotected unnatural α-amino acid derivatives by ruthenium-catalyzed direct asymmetric reductive amination, Angew. Chem., Int. Ed. 2022, 61, e202202552.

16. Liu, G.; Zheng, L.; Tian, K.; Wang, H.; Chung, L. W.; Zhang, X.; Dong, X.-Q. Ir-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles: Scope Investigations and Mechanistic Studies. CCS Chem. 2022, DOI: 10.31635/ccschem.022.202101643.

17. Zhang, J.-S.; Jiang, Y.-F.; Guan, F.; Zhang, S.; Xu, C.-Q.; Bai, S.-T.; Wen, J.; Li, J.; Zhang, X., Assessing Dual Rh/Ru Cascade Catalysts in One-Pot Homogeneous Synthesis of Ethanol from Syngas and Methanol, CCS Chem. 2022, DOI: 10.31635/ccschem.022.202202048.

18. Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.; Lu, Y.; Zhang, X., Concise, scalable and enantioselective total synthesis of prostaglandins, Nat. Chem. 2021, 13, 692-697.

19. Wen, J.; Wang, F.; Zhang, X., Asymmetric hydrogenation catalyzed by first-row transition metal complexes, Chem. Soc. Rev. 2021, 50, 3211-3237.

20. Wang, H.; Wen, J.; Zhang, X., Chiral Tridentate Ligands in Transition Metal-Catalyzed Asymmetric Hydrogenation, Chem. Rev. 2021, 121, 7530-7567.