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成果及论文

一、代表性论文

2022年:

1.  L. He, L.-H. He, S. Xu, T.-B. Ren*, X.-X. Zhang, Z.-J. Qin, X.-B. Zhang, L. Yuan*. Engineering of Reversible NIR‐II Redox‐Responsive Fluorescent Probes for Imaging of Inflammation In Vivo. Angew. Chem. Int. Ed202261, e202211409.

2.  J. Yuan, Q. H. Zhou, S. Xu, W. Li, X. X. Zhang, T. B. Ren,  L. Yuan*, X. B. Zhang*. Enhancing the Release Efficiency of Molecular Chemotherapeutic Prodrug by Photodynamic Therapy. Angew. Chem. Int. Ed202261, e202206169.

3.  Chen, K.Cai, J.Wang, S.Li, Y.Yang, C.Fu, T.Zhao, Z.Zhang, X.Tan, W.Angew. Chem. Int. Ed. 2023135, e202208451.

4.  Z. Qin, T.-B. Ren, H. Zhou, X. Zhang, L. He, Z. Li, X.-B. Zhang. L. Yuan*. NIRII-HDs: A Versatile Platform for Developing Activatable NIR-II Fluorogenic Probes for Reliable In Vivo Analyte Sensing. Angew. Chem. Int. Ed2022, 61, e202201541.

5.  Z. Dong, P. Liang, G. Q. Guan, B. L. Yin, Y. J. Wang, R. Y. Yue, X. B. Zhang, G. S. Song*. Overcoming Hypoxia‐Induced Ferroptosis Resistance via a 19F/1H‐MRI Traceable Core‐Shell Nanostructure. Angew. Chem. Int. Ed2022134, e202206074.

6.  G. Q. Guan, C. Zhang, H. Y. Liu, Y. J. Wang, Z. Dong, C. Lu, B. Nan, R. Y. Yue, X. Yin, X. B. Zhang, G. S. Song*. Ternary Alloy PtWMn as a Mn Nanoreservoir for High‐Field MRI Monitoring and Highly Selective Ferroptosis Therapy. Angew. Chem. Int. Ed. 2022134, e202117229.

7.  Renye Yue, Cheng Zhang, Li Xu, Youjuan Wang, Guoqiang Guan, Lingling Lei, Xiaobing Zhang, Guosheng Song. Dual key co-activated nanoplatform for switchable MRI monitoring accurate ferroptosis-based synergistic therapy, Chem, 2022, 8(7).

8.  Y. Liu, L. Teng, B. Yin, H.Meng, X. Yin, S. Huan, .G. S. Song*, X. B. Zhang*. Chemical design of activatable photoacoustic probes for precise biomedical applications. Chemical Reviews2022122(6), 6850-6918.

9.  G. Jiang, T.-B. Ren, E. D’Este, M. Xiong, B. Xiong, K. Johnsson, X.-B. Zhang, L. Wang*, L. Yuan*. A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy. Nat. Commun., 202213, 2264.

10.  Y. Liu, L. Teng,  Y. Lyu, G. S. Song*, X. B. Zhang,W. Tan. Ratiometric afterglow luminescent nanoplatform enables reliable quantification and molecular imaging. Nat. Commun., 202213, 2216.

2021年:

1.  Tian-Bing Ren, Zhi-Yao Wang, Zhen Xiang, Peng Lu, Huan-Hua Lai, Lin Yuan, Xiao-Bing Zhang*, Weihong Tan, A general strategy for development of activatable NIR-II fluorescent probes for in vivo high-contrast bioimaging, Angew. Chem. Int. Ed., 2021, 60, 800–805.

2.  Youjuan Wang, Guosheng Song, Shiyi Liao, Qiaoqiao Qin, Yan Zhao, Linan Shi, Kesong Guan, Xiangyang Gong, Peng Wang, Xia Yin, Qian Chen, Xiao-Bing Zhang*, Cyclic Amplification of the Afterglow Luminescent Nanoreporter Enables to Predict Anti-cancer Efficiency, Angew. Chem. Int. Ed., 2021, 60, 19779-19789.

3.  Yong-Xiang Wu, Dailiang Zhang, Xiaoxiao Hu, Ruizi Peng, Junbin Li, Xiaobing Zhang* and Weihong Tan*, Multicolor two-photon nanosystem for multiplexed intracellular imaging and targeted cancer therapy, Angew. Chem. Int. Ed., 2021, 60, 12569-12576.

4.  Dan Wang, Shenhuan Li, Zilong Zhao, Xiaobing Zhang*, and Weihong Tan*, Engineering a second-order DNA logic-gated nanorobot to sense and release on live cell membranes for multiplexed diagnosis and synergistic therapy, Angew. Chem. Int. Ed., 2021, 60, 15816-15820.

5.  Ke Li, Tian-Bing Ren, Shuangyan Huan, Lin Yuan*, Xiaobing Zhang*, Progress and perspective of solid-state organic fluorophores for biomedical applications, J. Am. Chem. Soc., 2021, 143, 21143-21160.

6.   Linan Shi, Youjuan Wang, Cheng Zhang, Yan Zhao, Chang Lu, Baoli Yin, Yue Yang, Xiangyang Gong, Lili Teng, Yanlan Liu, Xiaobing Zhang, Guosheng Song*, An acidity-unlocked magnetic nanoplatform enables self-boosting ROS generation through upregulation of lactate for imaging-guided highly specific chemodynamic therapy, Angew. Chem. Int. Ed., 2021, 60, 2-13.

7.  Lili Teng, Xiaoyu Han, Yongchao Liu, Chang Lu, Baoli Yin, Shuangyan Huan, Xia Yin, XiaoBing Zhang, and Guosheng Song*, Smart nanozyme platform with activity-correlated ratiometric molecular imaging for predicting therapeutic effects, Angew. Chem. Int. Ed., 2021, 60, 26142-26150.

2020年:

1.  Xiaoyi Fu, Guoliang Ke,  Fangqi Peng, Xue Hu, Jiaqi Li, Yuyan Shi, Gezhi Kong, Xiao-Bing Zhang* and Weihong Tan, Size-selective Molecular Recognition based on a Confined DNA Molecular Sieve using Cavity-tunable Framework Nucleic Acids, Nature Commun., 2020, 11, 1518-1529.

2.  Ruizi Peng, Liujun Xu, Huijing Wang, Yifan Lyu, Dan Wang, Cheng Bi, Cheng Cui, Chunhai Fan, Qiaoling Liu,* Xiao-Bing Zhang,* Weihong Tan,* DNA-based artificial molecular signaling system that mimics basic elements of reception and response, Nature Commun., 202011, 978.

3. Shuai Xu, Hong-Wen Liu, Lanlan Chen, Jie Yuan, Yongchao Liu, Lili Teng, Shuang-Yan Huan, Lin Yuan, Xiao-Bing Zhang*, Weihong Tan, Learning from Artemisinin: Bioinspired Design of a Reaction-Based Fluorescent Probe for the Selective Sensing of Labile Heme in Complex Biosystems, J. Am. Chem. Soc.2020142, 2129-2133.

4. Mengyi Xiong, Zhenglin Yang, Ryan J. Lake, Junjie Li, Shanni Hong, Huanhuan Fan, Xiao-Bing Zhang* and Yi Lu*, DNAzyme-Mediated Genetically Encoded Sensors for Ratiometric Imaging of Metal Ions in Living Cells, Angew. Chem. Int. Ed.2020, 59, 1891-1896.

2019年及以前:

1. Lili Teng, Guosheng Song, Yongchao Liu, Xiaoyu Han, Zhe Li, Youjuan Wang, Shuangyan Huan, Xiao-Bing Zhang* and Weihong Tan, Nitric Oxide-Activated “Dual-Key−One-Lock” Nanoprobe for in Vivo Molecular Imaging and High-Specificity Cancer Therapy, J. Am. Chem. Soc.2019141, 13572-13581.

2. Lili Zhang, Razack Abdullah, Xiaoxiao Hu, Huarong Bai, Huanhuan Fan, Lei He, Hao Liang, Jianmei Zou, Yanlan Liu, Yang Sun, Xiao-Bing Zhang*, Weihong Tan*, Engineering of Bioinspired, Size-Controllable, Self-Degradable Cancer-Targeting DNA Nanoflowers via the Incorporation of an Artificial Sandwich Base, J. Am. Chem. Soc.2019141, 4282-4290.

3. Yue Yang, Mei Chen, Bingzhe Wang, Peng Wang, Yongchun Liu, Yan Zhao, Kun Li, Guosheng Song, Xiao-Bing Zhang*, Weihong Tan, NIR-II Driven Plasmon-Enhanced Catalysis for Timely Supply of Oxygen to Overcome Hypoxia Induced Radiotherapy Tolerance, Angew. Chem. Int. Ed.2019, 58, 15069-15075.

4. Yuan Wu, Liqin Zhang, Cheng Cui, Sena Cansiz, Hao Liang, Cuichen Wu, I-Ting Teng, Weijun Chen, Yuan Liu, Weijia Hou, Xiao-Bing Zhang*, Weihong Tan*, Enhanced targeted gene transduction: AAV2 vectors conjugated to multiple aptamers via reducible disulfide linkages, J. Am. Chem. Soc.2018140, 2-5.

5. Hong-Wen Liu, Ke Li, Xiao-Xiao Hu, Longmin Zhu, Qiming Rong, Yongchao Liu; Xiao-Bing Zhang,* Jens Hasserodt, Feng-Li Qu, Weihong Tan, In situ localization of enzyme activity in live cells by a molecular probe releasing a precipitating fluorochrome, Angew. Chem. Int. Ed.201756, 11788-11792

6. Huanhuan Fan, Guobei Yan, Zilong Zhao, Xiaoxiao Hu, Wenhan Zhang, Hui Liu, Xiaoyi Fu, Ting Fu, Xiao-Bing Zhang* and Weihong Tan*, A Smart Photosensitizer-MnO2 Nanosystem for Enhanced Photodynamic Therapy via Reducing Glutathione Levels in Cancer Cells, Angew. Chem. Int. Ed.201655, 5477-5482.

7. Hong-Min Meng, Hui Liu, Hailan Kuai, Ruizi Peng, Liuting Mo and Xiao-Bing Zhang*, Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy, Chem. Soc. Rev., 2016, 45, 2583-2602.

8. Yifan Lv, Rong Hu, Guizhi Zhu, Xiao-Bing Zhang,* Lei Mei, Qiaoling Liu, Liping Qiu, Cuichen Wu, Weihong Tan*, Preparation and biomedical applications of programmable and multifunctional DNA nanoflowers, Nature Protocols, 201510, 1508-1524.

9. Zhi-Ling Song, Zhuo Chen*, Xia Bian, Li-Yi Zhou, Ding Ding, Hao Liang, Yu-Xiu  Shan-Shan Zou, Wang, Long Chen, Chao Yang, Xiao-Bing Zhang*, and Weihong Tan*, Alkyne-Functionalized Superstable Graphitic Silver Nanoparticles for Raman Imaging, J. Am. Chem. Soc. 2014, 136, 13558-13561.

10. Hao Liang, Xiao-Bing Zhang,* Yifan Lv, Liang Gong, Ruowen Wang, Xiaoyan Zhu, Ronghua Yang* and Weihong Tan*. Functional DNA-Containing Nanomaterials: Cellular Applications in Biosensing, Imaging, and Targeted Therapy, Acc. Chem. Res. 2014, 47, 1891-1901.

11. Cuichen Wu, Da Han, Tao Chen, Lu Peng, Guizhi Zhu, Mingxu You, Liping Qiu, Kwame Sefah, Xiao-Bing Zhang*, Weihong Tan*, Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy. J. Am. Chem. Soc. 2013, 135, 18644-18650.

12. Zilong Zhao, Hongmin Meng, Nannan Wang, Michael J. Donovan, Ting Fu, Mingxu You, Xiao-Bing Zhang*, Weihong Tan*, A Controlled-release Nanocarrier with  pHe-driven Targeting and Translocation for Drug Delivery. Angew. Chem. Int. Ed. 201352, 7487-7491.

13. Tao Chen, Cuichen Sam Wu, Elizabeth Jimenez, Zhi Zhu, Joshua G. Dajac, Mingxu You, Da Han, Xiao-Bing Zhang*, and Weihong Tan*, DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy, Angew. Chem. Int. Ed. 201352, 2012-2016.

14. Mingxu You, Yan Chen, Xiao-Bing Zhang*, Haipeng Liu, Ruowen Wang, Kelong Wang, KathrynR.Williams, and Weihong Tan*, An Autonomous and Controllable Light-Driven DNA Walking Device. Angew. Chem. Int. Ed. 201251, 2457-2460.

15. Tao Chen, Ismail Oecsoy, Quan Yuan, Ruowen Wang, Mingxu You, Zilong Zhao, Erqun Song, Xiao-Bing Zhang*, Weihong Tan,* One-Step Facile Surface Engineering of Hydrophobic Nanocrystals with Designer Molecular Recognition. J. Am. Chem. Soc. 2012, 134, 13164-13167.

16. Liu Yang, Ling Meng, Xiao-Bing Zhang*, Yan Chen, Guizhi Zhu, Haipeng Liu, Kwame Sefah and Weihong Tan*, Engineering Polymeric Aptamers for Selective Cytotoxicity. J. Am. Chem. Soc. 2011133, 13380-13386.

17. Li-Min Lu, Xiao-Bing Zhang*, Rong-Mei Kong, Bin Yang, Weihong Tan*, Ligation-triggered DNAzyme Cascade for Amplified Fluorescence Detection of Biological Small Molecules with Zero-Background Signal. J. Am. Chem. Soc. 2011133, 11686-11691.


二、授权专利

2022年:

1.   张晓兵,袁林,任天兵,卢鹏,文思雨,一种比率型ATP荧光探针及其合成方法与应用.2019111734707.

2.   张晓兵,袁林,任天兵,卢鹏,赖焕华,一种近红外二区染料及其合成方法. 2020108510084.

3.   袁林,李伟,张晓兵,尹姝璐,龚向阳,一种硫酸酯酶的比率型双光子荧光探针及其合成方法和应用. 2019107960847.

4.   张晓兵,徐帅,袁婕,刘永超,宦双燕,袁林,一种反应型游离亚铁血红素特异性响应的小分子荧光探针及其合成方法和应用. 2019113569738.

5.   宋国胜,刘慧怡,关国强,张成,一种基于三元合金PtW-Mn的纳米探针、制备方法及其应用. 2021114965486.

6.   张晓兵,李珂,袁林,宦双燕,一种近红外固态发光的荧光探针及其制备方法与应用. 2021100895295.

2021年前(含2021年):

1.   宋国胜,陈芳芳,张晓兵,基于普鲁士蓝的纳米探针及其制备方法和应用. 2019113668108.

2.   袁林,程丹,张晓兵,吕芸,柳东杰,魏艳芬,一种氨基苯并吡喃花菁类荧光染料和探针及其合成方法与应用. 2018111247913.

3.   袁林,任天兵,张晓兵,张维,一种吩嗪耦合结构的荧光染料及其合成方法. 2018104377594.

4.   宋国胜,陆畅,一种化学发光体系及其制备方法和应用. 2019113697505.

5.   宋国胜,师丽楠,张晓兵,一种基于他莫昔芬的金属-纳米药物的制备方法及其产品与应用. 2020100492209.

6.   张晓兵,刘永超,滕丽丽,许成艳,刘红文,徐帅,郭昊威,一种亮氨酸氨肽酶和单胺氧化酶激活的近红外荧光探针、合成方法及生物应用. 2019109179024.

7.   张晓兵,杨婵,宋国胜,宦双燕,种五氟尿嘧啶纳米药物制剂的制备方法及其应用. 2019106556038.

8.   张晓兵,刘红文,谭蔚泓,一种沉淀型碱性磷酸酶荧光探针及其合成方法和应用. 2017105920263.

9.   袁林,任天兵,张晓兵,王志尧,一种花菁类荧光染料及其合成方法. 2018104377448.

10.  张晓兵,范换换,谭蔚泓,赵子龙,种基因沉默试剂盒及方法. 201510072809X.

11.  谭蔚泓,张晓兵,谭晓红,丁玎,一种检测组氨酸标签重组蛋白的核酸适配体分子信标探针及其检测方法,201210193143X.


三、主要科研项目

2023年:

1. 国家自然科学基金重点项目,22234003,小分子荧光探针有序组装机原位生物成像应用,280万,2023.01-2027.12(主持人:张晓兵)

2. 国自科面上项目,22274043,机器学习辅助单颗粒成像用于病毒S蛋白与宿主细胞特异性作用的定量分析,54万,2023.01-2026.12(主持人:熊斌)

2022年:

1. 国家自然科学基金-联合基金-重点项目,U21A20287,可激活近红外光敏剂的构建及在肿瘤精准治疗中的应用探索,260万元,2022.01-2025.12 (主持人:宋国胜)

2. 国家优秀青年科学基金项目,22122403,生物分析化学,200万,2022.01-2024.12 (主持人:柯国梁)

2021年:

1. 湖南省杰出青年科学基金项目,2021JJ10012,生化分析及生物传感,50万,2021.01-2023.12(主持人:柯国梁)

2. 国自科面上项目,22074036,高灵敏成像检测炎症介导的癌变细胞及活体内NADH变化的分子荧光探针研究,65万,2021.01-2024.12(主持人:袁林)

3. 国自科青年基金,22004033,基于主客体策略的化学发光超分子探针构建及在肾损伤检测中的应用研究,24万,2021.01-2023.12(主持人:任天兵)

2021年前:

1. 国家重点研发计划项目,2019YFA0210100,动脉粥样硬化表观遗传相关活性氧的纳米检测与应用,1405万元,2020.01-2024.12(主持人:张晓兵)

2. 国家自然科学基金—重点项目子课题,21735001,生物体系自助式原位荧光信号放大平台的创建及生化应用(参与合作),50万元,2020.01-2022.12(主持人:袁林)

3. 国家自然科学基金面上项目,21977027,反应型近红外荧光/光声双模比率成像探针的构建及其在溶血模型中的应用研究,65万元,2020.01-2023.12(主持人:宦双燕)

4. 国家自然科学基金面上项目,21974039,基于DNA可控组装的双光子比率型荧光探针构建及卵巢癌相关检测与成像研究,65万元,2020.01-2023.12(主持人:尹霞)

5. 国家自然科学基金重大项目课题,21890744,肿瘤标志物的分子识别工具与识别策略,450万元,2019.01-2023.12(主持人:张晓兵)

6. 国自科面上项目,21877029,近红外荧光/光声双模态成像探针用于药物性肝损伤检测与治疗药物疗效评估的研究,67.5万元,2019.01-2022.12(主持人:袁林)

7. 国自科面上项目,51872088,空心氧化铁@全氟碳/氧气纳米平台的开发及协同增强放疗的应用研究,60万元,2019.01-2022.12(主持人:宋国胜)

8. 国自科面上项目,21874039,基于单颗粒示踪技术的膜受体蛋白与配体分子相互作用的原位动态分析,64万元,2019.01-2022.12(主持人:熊斌)

9. 湖南省科技厅,2019RS1031,分子医学高层次人才与创新团队,200万,2019.08-2022.07(主持人:张晓兵)

10. 国家自然科学基金面上项目,21675043,基于适体酶的双光子DNA水凝胶用于细菌感染,65万元,2017.01-2020.12(主持人:宦双燕)

11. 湖南省科技计划项目,2016RS2009,湖南省创新平台与人才计划,100万元,2016.01-2018.12(主持人:张晓兵)

12. 国家杰出青年科学基金项目,21325520,生化分析及生物传感,320万元,2014.01-2017.12(主持人:张晓兵)

13. 国家重大科学研究计划课题,2011CB911003,基于核酸适配体的蛋白质分离与富集新技术研究,292万元,2011.06-2015.05(主持人:张晓兵)


四、获奖信息

2020年及以后:

1. 张晓兵(第1完成人),国家自然科学二等奖,2020年

2. 宋国胜,国家级“青年长江学者”人才称号,2021年

3. 柯国梁,国家级“优秀青年基金”资助,2021年

4. 袁林,第五批国家“万人计划”青年拔尖项目,2021年

5. 袁林,科技创新领军人才(湖南省),2021年

6. 柯国梁,“杰出青年基金”资助(湖南省),2021年

2020年前:

1. 张晓兵(第1完成人),自然科学一等奖(教育部),2018年 

2. 张晓兵(第1完成人),自然科学一等奖(湖南省),2018年

3. 张晓兵,有突出贡献中青年专家(国家人事部),2017年

4. 张晓兵,国家“万人计划”科技创新领军人才(中组部),2017年

5. 张晓兵,长江学者特聘教授(教育部),2016年

6. 张晓兵,国家中青年科技创新领军人才(科技部),2016年