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成果及论文

2023

1.    Yue Wu#, Zhongting Zhao#, Naidi Yang#, Chenqi Xin, Zheng Li, Jiajia Xu, Bo Ma, Kah-Leong Lim, Lin Li, Qiong Wu*, Changmin Yu*, Chengwu Zhang.* Vitamin B12 ameliorates the pathological phenotypes of multiple Parkinson's disease models by alleviating oxidative stress. Antioxidants, 2023, 12, 153.  link

2022
2.       Lihua Huang, Bicong Zhou, Changmin Yu*, Qian Shen, Zhongxi Huang, Qiong Wu, Naidi Yang, Lin Li*, and Wei Huang*. Ultrastable gold nanoparticles-based nanoplatform with mitochondria targeting and high-fidelity intracellular bioimaging enterokinase levels. Sens. Actuators B, 2022, 372, 132666. link

3.       Qianhui Qi#, Jiaying Geng#, Weizhen An, Qiong Wu, Nan Wang, Yu Zhang, Xue Li, Qian Shen*, Wei Wang*, Changmin Yu*, and Lin Li*. Stimulus-Responsive Degradation of Silica Nanoparticles for Biomedical Applications: From the Degradation Behavior to Mechanism. 2022, preparing. 

4.       Chenhan Wang#, Duoteng Zhang#, Haiyan Yang#, Liang Shi, Lin Li, Changmin Yu*, Jifu Wei*, Qiang Ding*. A light-activated magnetic bead strategy utilized in spatio-temporal controllable exosomes isolation. Front. Bioeng. Biotechnol. 2022, 10, 1006374.  link

5.       Xiaojing Ling#, Yongxin Liu#, Danxuan Zhu#, Weizhen An, Jiaying Geng, Lin Li, Changmin Yu*, Jifu Wei*. Colorimetric visualization of histamine secreted by basophils based on DSP-functionalized gold nanoparticles. Anal. Methods, 2022, 14 (27), 2698-2702. link

6.       Changmin Yu#, Shuangxi Wang#, Chenchen Xu#, Yang Ding, Gaobin Zhang, Naidi Yang, Qiong Wu, Qicai Xiao, Limin Wang, Bin Fang, Chibin Pu, Jingyan Ge, Liqian Gao, Lin Li,* and Shao Q. Yao.* Two-photon small-molecule fluorogenic probes for visualizing endogenous nitroreductase activities from tumor tissues of a cancer patient. Adv. Healthcare Mater. 2022, 2200400. link

7.       Jinhua Liu*, Guotong Ruan, Wenlin Ma, Yujie Sun, Haidong Yu, Zhihui Xu, Changmin Yu, Hai Li, Chengwu Zhang*, Lin Li*. Horseradish peroxidase-triggered direct in situ fluorescent immunoassay platform for sensing cardiac troponin I and SARS-CoV-2 nucleocapsid protein in serum. Biosens. Bioelectron., 2022, 198, 11382. link

8.       Lihua Huang, Zonghao Sun, Qian Shen, Zhongxi Huang, Shuangxi Wang, Nai-di Yang, Gongqiang Li, Qiong Wu*, Wei Wang*, Lin Li, Changmin Yu*. Rational design of nanocarriers for mitochondria-targeted drug delivery. Chin. Chem. Lett., 2022, 33(9), 4146-4156. link

9.       Yongxin Liu # , Mengda Cao # , Zhongxi Huang # , Changmin Yu*, Nai-Di Yang, Qiong Wu, Wenjie Duan, Yi Zhu, Ji-Fu Wei*, Li Lin*, Wei Huang. Ultrasensitive detection of IgE levels based on magnetic nanocapturer linked immunosensor assay for early diagnosis of cancer. Chin. Chem. Lett. , 2022, 33(4), 1855-1860. link

10.   Xingwei Chen#, Zhongxi Huang#, Lihua Huang, Qian Shen, Nai-Di Yang, Chibin Pu*, Jinjun Shao*, Lin Li, Changmin Yu*, Wei Huang. Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging. RSC Adv., 2022, 12(3), 1393-1415. link

2021

11.   Wenhui Ji#, Jingyu Zhu#, Wanxia Wu#, Nanxiang Wang, Jiqing Wang, Jiansheng Wu, Qiong Wu*, Xuewen Wang, Changmin Yu, Gaofeng Wei*, Lin Li, Fengwei Huo*. Wearable Sweat Biosensors Refresh Personalized Health/Medical Diagnostics. Research, 2021, 9757126. link

12.   Bicong Zhou#, Xiaolu Guo#, Naidi Yang*, Zhongxi Huang, Lihuang, Huang, Zhijie Fang, Chengwu Zhang, Lin Li, Changmin Yu*. Surface engineering strategies of gold nanomaterials and their applications in biomedicine and detection. J. Mater. Chem. B, 2021, 9 (28), 5583-5598. link

13.   Jie Li,# Zhe Su,# Changmin Yu*, Yan Yuan, Qiong Wu, Jie Liu, Bo Peng, Wenbo Hu, Xiaomei Lu*, Haidong Yu, Lin Li*, Wei Huang. Recent progress in the development of sensing systems for in vivo detection of biological hydrogen sulfide. Dyes and pigments, 2021, 192, 109451. link

14.   Mengda Cao#, Yongxin Liu#, Chen Lu#, Miao Guo, Lin Li, Changmin Yu*, Ji-Fu Wei*. Ultrasensitive detection of specific IgE based on nanomagnetic capture and separation with AuNP-anti-IgE nanobioprobe for signal amplification. Anal. Methods, 2021, 13 (22), 2478-2484. link

15.   Mengda Cao#, Xisi Han#, Chen Lu#, Yujie Wang, Zhiqiang Xu, Shuangxi Wang, Bicong Zhou, Chengwu Zhang, Changmin Yu*, Lin Li*, Ji-Fu Wei*. A novel method for precise detection of allergen-specific IgE via immobilizing His-tagged allergens to paper-based device. Allergy, 2021, 76(2), 567-571.  link

16.   Haixiao Fang, Meirong Wu, Wenhui Ji, Limin Wang, Yipei Chen, Ding Chen, Naidi Yang, Qiong Wu, Changmin Yu, Jie Liu, Jinhua Liu, Hua Bai*, Bo Peng, Xiao Huang, Hai-Dong Yu*, and Lin Li*. Simultaneously Detecting Monoamine Oxidase A and B in Disease Cell/Tissue Samples Using Paper-Based Devices. ACS Appl. Bio Mater., 2021, 4, 2, 1395-1402. link


2020

17.   Haixiao Fang, Hang Zhang, Lin Li, Yun Ni, Riri Shi, Zheng Li, Xuekang Yang, Bo Ma, Chengwu Zhang, Qiong Wu, Changmin Yu, Naidi Yang, Shao Q. Yao, Wei Huang. Rational Design of a Two-Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues. Angew. Chem. Int. Ed., 2020, 59(19), 7536-7541. link


18.   Xisi Han#, Mengda Cao#, Bicong Zhou#, Changmin Yu*, Yongxin Liu, Bo Peng, Ling Meng, Ji-Fu Wei*, Lin Li*, Wei Huang. Specifically immobilizing His-tagged allergens to magnetic nanoparticles for fast and quantitative detection of allergen-specific IgE in serum samples. Talanta, 2020, 219, 121301. link


19.   Qian Shen#, Shuangxi Wang#, Nai-Di Yang, Chengwu Zhang, Qiong Wu*, Changmin Yu*. Recent development of small-molecule organic fluorophores for multifunctional bioimaging in the second near-infrared window. J. Lumin. 2020, 225, 117338. link


20.   Duoteng Zhang,# Wei Du,# Bo Peng,* Yun Ni, Haixiao Fang, Xinghan Qiu, Gaobin Zhang, Qiong Wu, Changmin Yu,* Lin Li,* Wei Huang. Two-photon small molecular fluorogenic probe visualizing biothiols and sulfides in living cells and zebrafishes. Sensors Actuat. B-Chem., 2020, 323, 128673. link

21.   Xingwei Chen,# Jiajia Xu,# Fengtai Suo,# Changmin Yu,* Duoteng Zhang, Jian Chen, Qiong Wu, Su Jing,* Lin Li,* Wei Huang. A novel naphthofluorescein-based probe for ultrasensitive point-of-care testing of zinc(II) ions and its bioimaging in living cells and zebrafishes. Spectrochim. Acta A. 2020, 229, 117949. link

22.   Shuangxi Wang, Bicong Zhou, Na Wang, Changmin Yu*, Nai-Di Yang, Jian Chen, Qiong Wu, Chengwu Zhang, Lin Li*, Wei Huang. Mitochondria-targeted fluorescent probe based on vibration-induced emission for real-time monitoring mitophagy-specific viscosity dynamic. Chin. Chem. Lett., 2020, 31(11), 2897-2902. link

23.   Hong Wang#, Jing Wei#, Chonghua Zhang*, Yuan Zhang, Yubin Zhang, Lin Li, Changmin Yu*, Peisheng Zhang, Jian Chen*. Red carbon dots as label-free two-photon fluorescent nanoprobes for imaging of formaldehyde in living cells and zebrafishes. Chin. Chem. Lett., 2020, 31(3), 759-763. link

2019
24.   Xiaofei Qin,# Changmin Yu,# Jing Wei, Lin Li,* Chengwu Zhang, Qiong Wu, Jinhua Liu, Shao Q. Yao,* Wei Huang.* Rational design of nanocarriers for intracellular protein delivery. Adv. Mater., 2019, 31(46), 1902791. link

25.   Fengtai Suo,# Xingwei Chen,# Changmin Yu,* Chengwu Zhang, Sheng Li, Qiong Wu,* Lin Li,* Wei Huang. Hybrid fluorophores-based fluorogenic paper device for visually high-throughput detection of Cu2+ in real samples. Dyes pigments, 2019, 170, 107639. link

26.   Xinghan Qiu, Chenqi Xin, Wenjing Qin, Zheng Li, Duoteng Zhang, Gaobin Zhang, Bo Peng,* Xu Han, Changmin Yu, Lin Li,* Wei Huang. A novel pyrimidine based deep-red fluorogenic probe for detecting hydrogen peroxide in Parkinson's disease models. Talanta, 2019, 199, 628-633. link

27.   Gaobin Zhang,# Yun Ni,# Duoteng Zhang, Hao Li, Nanxiang Wang, Changmin Yu,* Lin Li,* Wei Huang. Rational design of NIR fluorescence probes for sensitive detection of viscosity in living cells. Spectrochim. Acta A. 2019, 214, 339-347. link

28.   Hao Li,# Chenqi Xin,# Gaobin Zhang, Xisi Han, Wenjing Qin, Cheng-wu Zhang, Changmin Yu,* Su Jing,* Lin Li,* and Wei Huang. A mitochondria-targeted two-photon fluorogenic probe for dual-imaging viscosity and H2O2 level in Parkinson's disease models. J. Mater. Chem. B, 2019, 7(27), 4243-4251. link

29.   Xisi Han,# Mengda Cao,# Meirong Wu,# Yu-Jie Wang, Changmin Yu, Chengwu Zhang, Haidong Yu, Qiang Ju, Fengtai Suo, Ji-Fu Wei,* Lin Li,* Wei Huang.* A paper-based chemiluminescence immunoassay device for rapid and high-throughput detection of allergen-specific IgE. Analyst, 2019, 144, 2584-2593. link

30.   Jia Zhou,# Changmin Yu,#* Zheng Li, Pingping Peng, Duoteng Zhang, Xun Han, Hezhou Tang, Qiong Wu, Lin Li* and Wei Huang. A rapid and highly selective paper-based device for high-throughput detection of cysteine with red fluorescent emission and large Stokes shift. Anal. Methods, 2019, 11, 1312-1316. link

31.   Zhiman Bai,# Jing Wei,# Changmin Yu,* Xisi Han, Xiaofei Qin, Chengwu Zhang, Wenzhen Liao,* Lin Li,* and Wei Huang. Non-viral nanocarriers for intracellular delivery of microRNA therapeutics, J. Mater. Chem. B, 2019, 7, 1209-1225. link

32.   Yi Cao, Ziyin Li, Lianzhi Mao, Hehe Cao, Jingjing Kong, Bin Yu, Changmin Yu*, Wenzhen Liao*. The use of proteomic technologies to study molecular mechanisms of multidrug resistance in cancer. Eur. J. Med. Chem, 2019, 162, 423-434. link

33.   Na Wang, Chenqi Xin, Zheng Li, Gaobin Zhang, Lei Bai, Qiuyu Gong, Chenchen Xu, Xu Han, Changmin Yu*, Lin Li* and Wei Huang. A reversible fluorescent probe for directly monitoring protein-small molecules interaction utilizing vibration-induced emission, Dyes pigments, 2019, 163, 425-432. link

34.  Yang Ding#, Chenchen Xu#, Zheng Li, Wenjing Qin, Xisi Han, Chengwu Zhang, Xuchun Wang, Changmin Yu*, Lin Li*, Wei Huang.  Fast-response fluorogenic probe for visualizing hypochlorite in living cells and in zebrafish. Chem. Bio, Chem., 2019, 20, 831-837. link

35.   Zhe Su, Wenjing Qin, Lei Bai, Pengfei Sun, Changmin Yu*, Quli Fan, Lin Li *, Research progress on bioimaging with the second near-infrared fluorescence probes, Chinese Journal of Applied Chemistry, 2019, 36, 123-136. link

36.   Jing Wei, Xisi Han, Chengwu Zhang, Qiong Wu, Xiaofei Qin, Lin Li, Changmin Yu*, Wei Huang, Intracellular delivery of microRNA therapeutics based on nanocarriers: Current status and future perspective, Materials Review, 2019, 33, 16-26. link
2018
37.   Chenchen Xu, Chenqi Xin, Changmin Yu,* Meirong Wu, Jiajia Xu, Wenjing Qin, Yang Ding, Xuchun Wang, Lin Li* and Wei Huang. Fast response two-photon fluorogenic probe based on Schiff base derivatives for monitoring nitric oxide levels in living cells and zebrafish. Chem. Commun., 2018, 54, 13491-13494. link

38.     Pingping Peng, Hao Li, Lei Bai, Liulin Wang, Buxiang Chen, Changmin Yu,* Chengwu Zhang, Jingyan Ge, Lin Li,* and Wei Huang*. Photocontrollable fluorogenic probe for visualizing near-membrane hypochlorite in live cells. ChemistrySelect, 2018, 3(21), 5981-5986. link

39.     Wenjing Qin, Chenchen Xu, Yanfei Zhao, Changmin Yu,* Sheng Shen, Lin Li,* Wei Huang . Recent progress in small molecule fluorescent probes for nit roreductase, Chin. Chem. Lett., 2018, 29, 1451-1455. link

40.     Peng Zhao, Quan Xu, Jia Tao, Zongwen Jin, Yue Pan, Changmin Yu* and Zhiqiang Yu*. Near infrared quantum dots in biomedical applications: current status and future perspective. WIREs Nanomed Nanobiotechnol, 2018, 10(3), e1483. link

41.     Xin Mao, Peiyan Yuan*, Changmin Yu, Lin Li, Shao Q. Yao*. Nanoquencher-based selective imaging of protein glutathionylation in live mammalian cells. Angew. Chem. Int. Ed., 2018, 57(32), 10257-10272. link

42.     Bo Peng, Changmin Yu, Shubo Du, Si Si. Liew, Xin Mao, Peiyan Yuan, Zhenkun Na and Shao Q. Yao*. MSN-on-a-chip: Cell‐based screenings made possible on a small‐molecule microarray of native natural products. Chem. Bio, Chem., 2018, 19(9), 986-996. link


2017
43.     Wenhua Yang, Changmin Yu,* Chunxian Wu, Shao Q. Yao and Shuizhu Wu,* Cell-penetrating poly(disulfide)s-based star polymer for simultaneous intracellular delivery of miRNAs and small molecule drugs. Polym. Chem., 2017, 8, 4043-4051. link

44.     Peiyan Yuan, Xin Mao, Kok Chan Chong, Jiaqi Fu, Sijun Pan, Shuizhu Wu, Changmin Yu,* and Shao Q. Yao* Simultaneous imaging of endogenous survivin mRNA and on-demand drug release in live cells by using a mesoporous silica nanoquencher. Small, .2017, 13, 1700569. link

45.     Peiyan Yuan, Hailong Zhang, Linghui Qian, Xin Mao, Shubo Du, Changmin Yu, Bo Peng, Shao Q. Yao*. Intracellular delivery of functional native antibodies under hypoxic conditions by using a biodegradable silica nanoquencher. Angew. Chem. Int. Ed., 2017, 56(41), 12481-12485. link

46.     Meng Ni, Wenjun Zeng, Xin Xie, Zenglin Chen, Hao Wu, Changmin Yu, Bowen Li*. Intracellular enzyme-activatable prodrug for real-time monitoring of chlorambucil delivery and imaging. Chin. Chem. Lett., 2017, 28(6)1345-1351. link

2016

47.     Changmin Yu, Linghui Qian, Jingyan Ge, Jiaqi Fu, Peiyan Yuan, Samantha C. L. Yao, and Shao Q. Yao*. Cell-penetrating poly(disulfide) assisted intracellular delivery of mesoporous silica nanoparticles for inhibition of miR-21 function and detection of subsequent therapeutic effects. Angew. Chem. Int. Ed., 2016, 55(32), 9272-9276. link

48.     Qinghua Hu#, Changmin Yu#, Xitao Xia, Fang Zeng*, Shuizhu Wu*. A fluorescent probe for simultaneous discrimination of GSH and Cys/Hcy in human serum samples via distinctly-separated emissions with independent excitations. Biosens. Bioelectron., 2016, 81, 341-348. link

49.   Huiting Xie, Yinglong Wu, Jing Huang, Fang Zeng,* Hao Wu, Xitao Xia, Changmin Yu, Shuizhu Wu*. A ratiometric fluorescent probe for aluminum ions based-on monomer/excimer conversion and its applications to real samples. Talanta, 2016, 151, 8-13. link

50.   Yinglong Wu, Jun Wang, Fang Zeng,* Shuailing Huang, Jing Huang, Huiting Xie, Changmin Yu, and Shuizhu Wu*. Pyrene derivative emitting red or near-infrared light with monomer/excimer conversion and its application to ratiometric detection of hypochlorite. ACS Appl. Mater. Interfaces, 2016, 8(2), 1511-1519. link

2015

51.   Changmin Yu, Linghui Qian, Mahesh Uttamchandani, Lin Li, and Shao Q. Yao*. Single-vehicular delivery of antagomir and small molecules to inhibit miR-122 function in Hepatocellular Carcinoma cells by using “smart” mesoporous silica nanoparticles. Angew. Chem. Int. Ed., 2015, 54(36), 10574-10578. link

52.   Qinghua Hu, Fang Zeng*, Changmin Yu, Shuizhu Wu*. A fluorescent probe for alkaline phosphatase via excited state intramolecular proton transfer. Sens. Actuators B., 2015, 220, 720-726. link

53.   Jiaqi Fu, Changmin Yu, Lin Li, and Shao Q. Yao*. Intracellular delivery of functional proteins and native drugs by cell-penetrating poly(disulfide)s. J. Am. Chem. Soc., 2015, 137(37), 12153-12160. link

54.   Jiangsheng Xu, Fang Zeng,* Hao Wu, Changmin Yu, and Shuizhu Wu*. Dual-targeting nanosystem for enhancing photodynamic therapy efficiency. ACS Appl. Mater. Interfaces, 2015, 7(17), 9287-9296. link

55.   Yinglong Wu, Shuailing Huang, Fang Zeng,* Jun Wang, Changmin Yu, Jing Huang, Huiting Xie and Shuizhu Wu*. A ratiometric fluorescent system for carboxylesterase detection with AIE dots as FRET donors. Chem. Commun., 2015, 51(64), 12791-12794. link

2014
56.   Huafei Xie, Xiaohui Jiang, Fang Zeng*, Changmin Yu, Shuizhu Wu*. A novel ratiometric fluorescent probe through aggregation-induced emission and analyte-induced excimer dissociation. Sens. Actuators B, 2014, 203, 504-510. link

57.     Gang Fang, Fang Zeng,* Changmin Yu, Shuizhu Wu*. Low molecular weight PEIs modified by hydrazone-based crosslinker and betaine as improved gene carriers. Colloids Surf. B Biointerfaces, 2014, 122, 472-481. link

58.     Jiangsheng Xu, Fang Zeng,* Hao Wu, Caiping Hu, Changmin Yu, and Shuizhu Wu*. Preparation of a mitochondria-targeted and NO-releasing nanoplatform and its enhanced pro-apoptotic effect on cancer cells. Small, 2014, 10(18), 3750-3760. link

59.     Guangfei Wu, Fang Zeng, Changmin Yu, Shuizhu Wu*and Wensheng Li*. A ratiometric fluorescent nanoprobe for H2O2 sensing and in vivo detection of drug-induced oxidative damage to the digestive system. J. Mater. Chem. B, 2014, 2(48), 8528-8537. link

60.     Xianfeng Hou, Qingxiang Yu, Fang Zeng,* Changmin Yu and Shuizhu Wu*. Ratiometric fluorescence assay for γ-glutamyltranspeptidase detection based on a single fluorophore via analyte-induced variation of substitution. Chem. Commun., 2014, 50(26), 3417-3420. link

2013

61.     Changmin Yu, Yinglong Wu, Fang Zeng,* Xizhen Li, Jianbin Shi, and Shuizhu Wu*. Hyperbranched polyester-based fluorescent probe for histone deacetylase via aggregation-induced emission. Biomacromolecules, 2013, 14(12), 4507-4514. link

62.     Changmin Yu, Yinglong Wu, Fang Zeng* and Shuizhu Wu*. A fluorescent ratiometric nanosensor for detecting NO in aqueous media and imaging exogenous and endogenous NO in live cells. J. Mater. Chem. B, 2013, 1(33), 4152-4159. link

63.     Changmin Yu, Xizhen Li, Fang Zeng,* Fangyuan Zheng and Shuizhu Wu*. Carbon-dot-based ratiometric fluorescent sensor for detecting hydrogen sulfide in aqueous media and inside live cells. Chem. Commun., 2013, 49(4), 403-405. link

64.     Fangkai Du, Yunhao Ming, Fang Zeng,* Changmin Yu and Shuizhu Wu*. A low cytotoxic and ratiometric fluorescent nanosensor based on carbon-dots for intracellular pH sensing and mapping. Nanotechnology, 2013, 24(36), 365101. link

65.     Huafei Xie, Fang Zeng,* Changmin Yu and Shuizhu Wu*. A polylysine-based fluorescent probe for sulfite anion detection in aqueous media via analyte-induced charge generation and complexation. Polym. Chem., 2013, 4(21), 5416. link

66.     Fangyuan Zheng, Fang Zeng,* Changmin Yu, Xianfeng Hou, and Shuizhu Wu*. A PEGylated fluorescent turn-on sensor for detecting fluoride ions in totally aqueous media and its imaging in live cells. Chem. Eur. J., 2013, 19(3), 936-942. link

2012
67.     Changmin Yu, Ming Luo, Fang Zeng* and Shuizhu Wu*. A fast-responding fluorescent turn-on sensor for sensitive and selective detection of sulfite anions. Anal. Methods, 2012, 4(9), 2638-2640. link

68.     Changmin Yu, Fang Zeng,* Ming Luo and Shuizhu Wu*. A silica nanoparticle-based sensor for selective fluorescent detection of homocysteine via interaction differences between thiols and particle-surface-bound polymers. Nanotechnology, 2012, 23(30), 305503. link

2011

69.     Changmin Yu, Ming Luo, Fang Zeng,* Fangyuan Zheng and Shuizhu Wu*. Mesoporous silica particles for selective detection of dopamine with β-cyclodextrin as the selective barricade. Chem. Commun., 2011, 47(32), 9086-9088. link

2010
70.     Meiyun Xu, Shuizhu Wu*, Fang Zeng, and Changmin Yu. Cyclodextrin supramolecular complex as a water-soluble ratiometric sensor for ferric ion sensing. Langmuir, 2010, 26(6), 4529-4534. link