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成果及论文

代表论著:

25. J.-Z. Xiao, Z.-X. Cai, Z.-Z. Pan, Y. Wang, N. Jiang, L. Yin*. Copper(I)-Catalyzed Asymmetric 1,4-Hydroarsination of α,β-Unsaturated Compounds. Angew. Chem. Int. Ed. 2025, 64, e202413834.

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24. Z.-C. Liu, H.-M. Zhang, Y. Li, Z.-Q. Wang, L. Yin*. Copper(I)-Catalyzed Enantioselective α-Alkylation of 2-Acylimidazoles. J. Am. Chem. Soc. 2024, 146, 34265–34273.

23. N. Jiang, P.-Z. Liu, Z.-Z. Pan, S.-Q. Wang, Q. Peng*, L. Yin*. Asymmetric Synthesis of Trisubstituted Vicinal Diols through Copper(I)-Catalyzed Diastereoselective and Enantioselective Allylation of Ketones with Siloxypropadienes. Angew. Chem. Int. Ed. 2024, 63, e202402195.

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22. Z.-Z. Pan, J.-H. Li, H. Tian, L. Yin*. Copper(I)-Catalyzed Asymmetric Allylation of Ketones with 2-Aza-1,4-Dienes. Angew. Chem. Int. Ed. 2024, 63, e202315293.

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21. S. Zhang, N. Jiang, J.-Z. Xiao, G.-Q. Lin, L. Yin*. Copper(I)-Catalyzed Asymmetric Hydrophosphination of 3,3-Disubstituted Cyclopropenes. Angew. Chem. Int. Ed. 2023, 62, e202218798.

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20. H. Tian, H.-M. Zhang, L. Yin*. Copper(I)-Catalyzed Conjugate Addition/Enantioselective Protonation with Selenols and α-Substituted α,β-Unsaturated Thioamides. Angew. Chem. Int. Ed. 2023, 62, e202301422.

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19. Z.-Z. Pan, D. Pan, J.-H. Li, X.-S. Xue*, L. Yin*. Copper(I)-Catalyzed Asymmetric Conjugate Addition of 1,4-Dienes to β‑Substituted Alkenyl Azaarenes. J. Am. Chem. Soc. 2023, 145, 1749–1758.

18. B.-R. Wang, Y.-B. Li, Q. Zhang, D. Gao, P. Tian* Q. Li*, L. Yin*. Copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of 1,3-enynes and azomethine ylides. Nat. Commun. 2023, 14, 4688.


17. Z.-C. Liu, Z.-Q. Wang, X. Zhang, L. Yin*. Copper(I)-catalyzed asymmetric alkylation of α-imino-esters. Nat. Commun. 2023, 14, 2187.


16. Y.-B. Li, H. Tian, S. Zhang, J.-Z. Xiao, L. Yin*. Copper(I)-Catalyzed Asymmetric Synthesis of P-Chiral Aminophosphinites. Angew. Chem. Int. Ed. 2022, e202117760.

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15. S. Zhang, J.-Z. Xiao, Y.-B. Li, C.-Y. Shi, L. Yin*. Copper(I)-Catalyzed Asymmetric Alkylation of Unsymmetrical Secondary Phosphines. J. Am. Chem. Soc. 2021, 143, 9912−9921.

14. F. Zhong, Z.-Z. Pan, S.-W. Zhou, H.-J. Zhang, L. Yin*. Copper(I)-Catalyzed Regioselective Asymmetric Addition of 1,4-Pentadiene to Ketones. J. Am. Chem. Soc. 2021, 143, 4556−4562.

13. Q. Zhang, S.W. Zhou, C.-Y. Shi, L. Yin*. Catalytic Asymmetric Allylic Substitution with Copper(I) Homoenolates Generated from Cyclopropanols. Angew. Chem. Int. Ed. 2021, 60, 26351–26356.

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12.   C.-Y. Shi, J. Eun, T. R. Newhouse*, L. Yin*. Copper(I)-Catalyzed Asymmetric Conjugate 1,6-, 1,8-, and 1,10-Borylation. Angew. Chem. Int. Ed. 2021, 60, 9493–9499.

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11. S.-Q. Wang, Z.-C. Liu, W.-J. Yue, L. Yin*. Copper(I)-Catalyzed Asymmetric Vinylogous Aldol-Type Reaction of Allylazaarenes. Angew. Chem. Int. Ed. 2021, 60, 4604–4608.

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10. Y.-B. Li, H. Tian, L. Yin*. Copper(I)-Catalyzed Asymmetric 1,4-Conjugate Hydrophosphination of α,β-Unsaturated Amides. J. Am. Chem. Soc. 2020, 142, 20098−20106.

9. W.-J. Yue, J.-Z. Xiao, S. Zhang, L. Yin*. Rapid Synthesis of Chiral 1,2-Bisphosphine Derivatives through Copper(I)-Catalyzed Asymmetric Conjugate Hydrophosphination. Angew. Chem. Int. Ed. 2020, 59, 7057–7062.

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8. F. Zhong, Q.-Y. Xue, L. Yin*. Construction of Chiral 2,3-Allenols through a Copper(I)-Catalyzed Asymmetric Direct Alkynylogous Aldol Reaction. Angew. Chem. Int. Ed. 2020, 59, 1562–1566.

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7. C.-Y. Shi, Z.-Z. Pan, P. Tian*, L. Yin*. Copper(I)-catalyzed asymmetric 1,6-conjugate allylation. Nat. Commun. 2020, 11, 5480.


6. X.-C. Gan, C.-Y. Zhang, F. Zhong, P. Tian*, L. Yin*. Synthesis of chiral anti-1,2-diamine derivatives through copper(I)-catalyzed asymmetric α-addition of ketimines to aldimines. Nat. Commun. 2020, 11, 4473.


5. H.-J. Zhang, Y.-C. Xie. L. Yin*. Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines. Nat. Commun. 2019, 10, 1699.


4. F. Zhong, W.-J. Yue, H.-J. Zhang, C.-Y. Zhang, L. Yin*. Catalytic Asymmetric Construction of Halogenated Stereogenic Carbon Centers by Direct Vinylogous Mannich-Type Reaction. J. Am. Chem. Soc. 2018, 140, 15170−15175.

3. H.-J. Zhang, L. Yin*. Asymmetric Synthesis of α,β-Unsaturated δ‑Lactones through Copper(I)-Catalyzed Direct Vinylogous Aldol Reaction. J. Am. Chem. Soc. 2018, 140, 12270−12279.

2. H.-J. Zhang, A. W. Schuppe, S.-T. Pan, J.-X. Chen, B.-R. Wang, T. R. Newhouse*, L. Yin*. Copper-Catalyzed Vinylogous Aerobic Oxidation of Unsaturated Compounds with Air. J. Am. Chem. Soc. 2018, 140, 5300−5310.

1. H.-J. Zhang, C.-Y. Shi, F. Zhong, L. Yin*. Direct Asymmetric Vinylogous and Bisvinylogous Mannich-Type Reaction Catalyzed by a Copper(I) Complex. J. Am. Chem. Soc. 2017, 139, 2196−2199.