2021–Now: PI, Shanghai Institute of nutrition and health, Chinese Academy of Sciences
2017-2021: Postdoctoral Fellow, Lewis Sigler Institute, Princeton University, USA
2016-2016: Postdoctoral in chemistry and Bioengineering, Rice University, USA
2010-2016: Doctor of chemistry and Bioengineering, Rice University, USA
2006-2010: Bachelor, School of chemical engineering, Tianjin University

    From the interaction between organelles and cells in the micro world to the interdependence between tissues, organs, hosts and the surrounding environment in the macro world, metabolic reactions are changing dynamically. Traditional metabonomics can reflect the static abundance of metabolites, while metabolic flow analysis can help capture the changes of metabolic reaction rate in the process of cell and organ lesions, so that the two complement each other and effectively realize our deep metabolic cognition of metabolic diseases.
   Eutrophic diet and bad living habits can cause fatty liver, liver cirrhosis and liver cancer. After nutrients are absorbed by the small intestine, they carry a large number of high-energy electrons into hepatocytes, which affects the redox stress of the liver and further causes the imbalance of glucose and lipid metabolism of the host. Rebalancing the redox state of hepatocytes, excavating the metabolic root of hepatocyte metabolic imbalance and analyzing the metabolic interaction between hepatocytes and microenvironment will be conducive to the prevention and treatment of liver metabolic diseases. On the other hand, with the development of science and technology and the continuous development of scientists, nutritional intervention in the treatment of metabolic diseases will lead to a new era. Intermittent starvation therapy, amino acid restriction, ketogenic diet and other clinical treatment methods are constantly showing their effectiveness and superiority in basic research and clinical trials. Exploring the mechanism of the effect of nutritional intervention on diseases and the synergistic effect between nutritional intervention and clinical drugs will promote the clinical application of nutritional intervention and further improve the quality of life of patients.
    This research group will combine metabolomics, metabolic flow analysis and single-cell genomics to take in vitro cell model, rat and mouse disease model and clinical samples as experimental objects. The main research contents include the following three aspects:
1. Hepatocyte metabolism and its metabolic interaction with microenvironment in hepatic metabolic diseases
2. The mechanism of redox stress regulating organ operation and promoting the deterioration of metabolic diseases
3. The mechanism of nutritional intervention regulating organ metabolism and synergistic drug therapy