代表性论文：# First Authors
15. Lin Yang,# Wenbin Tu,# Lingying Leng,# Liyue Huang,# Wei Jiang, Mi Wang, Yu Wang, Jennifer L. Meagher, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Meilin Wang, Bo Wen, Duxin Sun, Lalgudi Harikrishnan, Corey Strickland, Cory Rice, Peter Orth, Zhihua Sui, Shaomeng Wang* “Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers” J. Med. Chem. 2025, https://doi.org/10.1021/acs.jmedchem.4c01904.
14. Lingying Leng,# Wenbin Tu,# Lin Yang,# Liyue Huang,# Mi Wang,# Jennifer L. Meagher, Krish napriya Chinnaswamy, Srinivasa Rao Allu, Rohan Kalyan Rej, Jelena Tosovic, Lalgudi Harikrishnan, Zhenwu Li, Zhihua Sui, Jeanne Stuckey, and Shaomeng Wang* “Discovery of High-Affinity SMARCA2/4 Bromodomain Ligands and Development of Potent and Exceptionally Selective SMARCA2 PROTAC Degraders” J. Med. Chem. 2025, https://doi.org/10.1021/acs.jmedchem.4c01903.
13. Zhenwu Li*, Lalgudi S. Harikrishnan, Guozhang Xu, Debangshu Samanta, Jose C. Clemente, Lingying Leng, Wenbin Tu, Lin Yang, Liyue Huang, Mi Wang, Shaomeng Wang, Qiaolin Deng, Elham Behshad, Rakesh Nagilla, Peter Orth, Cory Rice, Corey Strickland, Helai P. Mohammad, E. Scott Priestley, and Zhihua Sui* “Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders” J. Med. Chem. 2024, https://doi.org/10.1021/acs.jmedchem.4c01878.
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Before ZJU：
12. Yang, L. ; Tu, W. ; Huang, L.; Leng, L.; Jiang, W.; Leng, L.; Wang, M.; Wen, B.; Sun, D.; Stuckey, J.; Wang, S.* “Development of potent, highly selective and efficacious SMARCA2 degraders” Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024, 84, 3879.
11. Leng, L.; Yang, L.; Tu, W.; Rej, R.; Allu, S. R.; Huang, L.; Jiang, W.; Wang, Y.; Stuckey, J.; Sarkari, F. R.; Wang, M.; Wang, L.; Wen, B.; Sun, D.; Wang, S.* “Discovery of potent, highly selective and orally efficacious SMARCA2 degraders” Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024; 84, 4506.
10. Yang, L. #; Tu, W. #; Huang, L.; Miao, B.; Kaneshige, A.; Jiang, W.; Leng, L.; Wang, M.; Wen, B.; Sun, D.; Wang, S.* “Discovery of SMD-3040 as a potent and selective SMARCA2 PROTAC degrader with strong in vivo antitumor activity” J. Med. Chem. 2023, 66, 10761–10781.
9. Yang, L.; Wurm, T.; Poudel, B. S.; Krische, M. J.* “Enantioselective Total Synthesis of Andrographolide and 14-Hydroxy-Colladonin: Carbonyl Reductive Coupling and trans-Decalin Formation via Hydrogen Transfer” Angew. Chem. Int. Ed. 2020, 59, 59, 23169–23173. (Very Important Paper)
8. Yang, L.#; Kong, L.#; Gu, Q.#; Shao, S.; Lin, G.-Q.; Hong, R.* “Stereoselective Access to Polypropionates Expedited by the Double Hydroboration of Allenes: Total Synthesis of Antitumor (−)-Pironetin” CCS Chem. 2020, 2, 769–779. (# Equal contribution)
7. Yang, L.; Hong, R.* “Integration of Novel Strategy and Methods: Total Synthesis of Antitumor Lasonolide A” in “Strategies and Tactics in Organic Synthesis” (Chapter 4) 2019, Vol. 14, pp 107–138.
6. Yang, L.; Lin, Z.-M.; Shao, S,-J.; Zhao, Q.; Hong, R.* “Enantioconvergent and Concise Synthesis of Lasonolide A” Angew. Chem. Int. Ed. 2018, 57, 16200–16204.
5. Yang, L.; Lin, Z.-M.; Huang, S.-H.*; Hong, R.* “Stereodivergent Synthesis of Functionalized Tetrahydropyrans Accelerated by Mechanism-Based Allylboration and Bioinspired Oxa-Michael Cyclization” Angew. Chem. Int. Ed. 2016, 55, 6280–6284.
4. Yang, L.#; He, G.-L.#; Yin, R.-F.#; Zhu, L.-L.; Wang, X.-X.; Hong, R.* “Synthesis of Polyketide Stereoarrays Enabled by a Traceless Oxonia-Cope Rearrangement” Angew. Chem. Int. Ed. 2014, 53, 11600–11604. (Highlighted by Chin. J. Org. Chem.，# Equal contribution)
3. Yang, L.; Lin, Z.; Zheng, K.; Kong, L.; Hong, R.* “A Modular Synthesis of Antitumor Macrolide (–)-Lasonolide A” Chin. J. Chem. 2020, 38, 725–736.
2. Gu, Q.; Kong, L.; Yang, L.; Zhu, L.; and Hong R.* “A Stereotetrad-centered Strategy Toward Pironetin: Dead Ends, Detour, and Evolution of the Synthetic Strategy” Tetrahedron 2020, 76, 131660.
1. Bai, D.-H.; Huang, S.-H.*; Lin, Z.-M.; Yang, L.; Dai, J.-Z.; Huang, M.-Y.; Jia, X.-S.*; Hong, R.* “Aza-Belluš-Claisen Rearrangement Enabled Synthesis of Racemic Tapentadol and Its Stereoisomers” Chin. J. Chem. 2013, 31, 317–320. (Selected as the Cover Paper)
专利成果
1. Shaomeng Wang#; Lingying Leng#; Wenbin Tu#; Lin Yang#; Mi Wang; Paul Kirchhoff; Guozhang Xu; Zhenwu Li; Jelena Tosovic; Jeanne Stuckey “Preparation of indoloquinazoline compounds and compositions as SMARCA2/4 degraders and uses thereof” WO2024064316.
2. Shaomeng Wang#; Lingying Leng#; Lin Yang#; Wenbin Tu#; Liyue Huang; Mi Wang; Wei Jiang; Paul Kirchhoff; Guozhang Xu; Zhenwu Li; E., Scott Priestley; Jelena Tosovic; Jeanne Stuckey “Preparation of indoloquinazoline compounds and compositions as SMARCA2/4 degraders and uses thereof” WO2024064328.
3. Wang, Shaomeng#; Yang, Lin#; Leng, Lingying#; Rej, Rohan; Allu#, Srinivasa Rao#; Huang, Liyue; Tu, Wenbin; Jiang, Wei “Preparation of pyrazinopyridazinyl compounds as SMARCA2/4 degraders and uses thereof” WO2025106472.
4. Wang, Shaomeng#; Leng, Lingying#; Yang, Lin#; Rej, Rohan#; Allu, Srinivasa Rao#; Huang, Liyue; Tu, Wenbin; Jiang, Wei; Harikrishnan, Lalgudi; Li, Zhenwu; Knight, Steven D “Compounds and compositions as SMARCA2/4 degraders and uses thereof” WO2025106482.
5. Wang, Shaomeng#; Rej, Rohan#; Allu, Srinivasa Rao#; Yang, Lin#; Leng, Lingying#; Huang, Liyue; Tu, Wenbin; Jiang, Wei “Preparation of indoloquinazolinyl compounds as SMARCA2/4 degraders and uses thereof” WO2025106480.
学术交流
2024，杨林，Development of Potent, Highly Selective and Efficacious SMARCA2 Degraders，第115届美国癌症研究协会(AACR)年会，美国圣地亚哥，口头邀请报告。
