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成果及论文

C Chen†, Y Xiang†, KW Yang*, YJ Zhang, WM Wang, JP Su, Y Ge, Y Liu, "A protein structure-guided covalent scaffold selectively targets the B1 and B2 subclass metallo-β-lactamases", Chem. Commun., 2018, 54, 4802-4805.

KW Yang†*, YJ Zhou†, Y Ge, YJ Zhang, "Real-time activity monitoring of New Delhi metallo-β-lactamase-1 in living bacterial cells by UV-Vis spectroscopy", Chem. Commun., 2017, 53(57), 8014-8017.

XY Ouyang†*, YN Chang†, KW Yang†*, WM Wang, JJ Bai, JW Wang, YJ Zhang, SY Wang, BB Xie, LL Wang, "A DNA nanoribbon as a potent inhibitor of metallo-β-lactamases", Chem. Commun., 2017, 53(63), 8878-8881.

JB Zhen, MH Zhao, Y Ge, Y Liu, LW Xu, C Chen, YK Gong, KW Yang*, “Construction, mechanism and antibacterial resistance insight of the polypeptide-based nanoparticles”, Biomaterials Science, 2019, doi: 10.1039/C9BM01050E.

C Chen, Y Liu, YJ Zhang, Y Ge, JE Lei, KW Yang*, “The assemblage of covalent and metal binding dual functional scaffold for cross-class metallo-β-lactamases inhibition”, Future Medicinal Chemistry, 2019, accepted.

YJ Zhang†, WM Wang†, P Oelschlaeger, C Chen, JE Lei, M Lv, KW Yang*, "Real-time monitoring of NDM-1 activity in live bacterial cells by isothermal titration calorimetry: a new approach to measure inhibition of antibiotic-resistant bacteria", ACS Infectious Diseases, 2018, 4(12), 1671-1678.

Y Xiang†, C Chen†, WM Wang, LW Xu, KW Yang*, P Oelschlaeger, Y He*, "Rhodanine as a potent scaffold for the development of broad-spectrum metallo-β-lactamase inhibitors", ACS Med. Chem. Lett. 2018, 9, 359-364.

JP Su, JY Liu, C Chen, YJ Zhang, KW Yang*, "Ebsulfur as a potent scaffold for inhibition and labelling of New Delhi Metallo-β-lactamase-1 in vitro and in vivo", Bioorganic Chemistry, 2019, 84, 192-201.

M Lv, YJ Zhang, F Zhou, Y Ge, MH Zhao, Y Liu, KW Yang*, "Real-time monitoring of D-Ala-D-Ala dipeptidase activity of VanX in living bacteria by isothermal titration calorimetry", Anal. Biochem., 2019, 578, 29-35.

YJ Zhang, XL Liu, WM Wang, C Chen, MH Zhao, KW Yang*, "Amino acid thioesters exhibit inhibitory activity against B1-B3 subclasses of metallo-β-lactamases", Chem. Pharm. Bull., 2019,67(2) 1-9.

XL Liu†, Y Xiang†, C Chen, KW Yang*, "Azolylthioacetamides as potential inhibitors of New Delhi metallo-β-lactamase-1 (NDM-1)", Journal of Antibiotics, 2019, 72, 118-121.

Y Zhao, JL Wen, Y Ge, XT Zhang, H Shi, KW Yang, X Gao, SQ Shi*, YK Gong, "Fabrication of stable biomimetic coating on PDMS surface: cooperativity of multivalent interactions", Applied Surface Science, 2019, 469, 720-730.

YL Zhang*, Y Yan, LF Liang, J Feng, XJ Wang, L Li, and KW Yang, "Halogen-substituted triazolethioacetamides as a potent skeleton for the development of metallo-β-lactamase inhibitors", Molecules, 2019, 24, 1174; doi:10.3390/molecules24061174.

C Chen†, Y Xiang†, Y Liu, XD Hu, KW Yang*, "Mercaptoacetate thioesters and their hydrolysate mercaptoacetic acid jointly inhibit metallo-β-Lactamase L1", Med. Chem. Commun., 2018, 9, 1172-1177.

Q Wang†, Y He†*, R Lu, WM Wang, KW Yang, HM Fan, Y Jin, GM Blackburn, "Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids", Bioscience Reports, 2018, 38(2), doi: 10.1042/BSR20180244.

T Yu, X Shu, KW Yang, XD Hu*, "Biomimetic total synthesis of Scabellone B", Synlett, 2018, 29, 1617-1621.

YN Chang, Y Xiang, YJ Zhang, WM Wang, C Chen, P Oelschlaeger, KW Yang*, "Carbamylmethyl mercaptoacetate thioether: a novel scaffold for the development of L1 metallo-β-lactamase inhibitors", ACS Med. Chem. Lett. 2017, 8, 527-532.

Y Xiang, YN Chang, Y Ge, JS Kang, YL Zhang, XL Liu, P Oelschlaeger, KW Yang*, "Azolylthioacetamides as a potent scaffold for the development of metallo-β-lactamase inhibitors", Bioorg. Med. Chem. Lett. 2017, 27(23), 5225-5229.

Y Ge, YJ Zhou, KW Yang*, YL Zhang, Y Xiang, YJ Zhang, "Real-time activity assays of β-lactamases in living bacterial cells: application to the inhibition of antibiotic-resistant E. coli strains", Mol. BioSyst. 2017, 13, 2323-2327.

WJ Wang, Q Wang, Y Zhang, R Lu, YL Zhang, KW Yang*, JE Lei, Y He*, "Characterization of β-lactamase activity using isothermal titration calorimetry", BBA-General Gubjects, 2017, 1861(8), 2031-2038.

L Zhai, KW Yang*, "Porphyrin-vancomycin: a highly promising conjugate for the identification and photodynamic inactivation of antibiotic resistant Gram-positive pathogens", Dyes and Pigments, 2015, 120, 228-238.

JM Xiao, L Feng, LS Zhou, HZ Gao, YL Zhang, KW Yang*, "Novel fluorescent cephalosporins: synthesis, antimicrobial activity and photodynamic inactivation of antibiotic resistant bacteria", Eur. J. Med. Chem. 2013, 59, 150-159.

HZ Gao, KW Yang*, XL Wu, JY Liu, L Feng, JM Xiao, LS Zhou, C Jia, Z Shi, "Novel conjugation of norvancomycin-fluorescein for photodynamic inactivation of Bacillus subtilis", ACS Bioconjugate Chem. 2011, 22, 2217−2221.

L Zhai, YL Zhang, JS Kang, P Oelschlaeger, L Xiao, SS Nie, KW Yang*, "Triazolylthioacetamide: a valid scaffold for the development of New Delhi metallo-β-lactmase-1 (NDM-1) inhibitors", ACS Med. Chem. Lett. 2016, 7(4), 413-417.

T Christopeit, KW Yang, SK Yang, HK S. Leirosa, “The structure of the metallo-β-lactamase VIM-2 in complex with a triazolylthioacetamide inhibitor”, Acta Cryst. F. 2016, 72, 813-819.

XL Liu, KW Yang*, YJ Zhang, Y Ge, Y Xiang, YN Chang, P Oelschlaege, "Optimization of amino acid thioesters as inhibitors of metallo-β-lactamase L1", Bioorg. Med. Chem. Lett. 2016, 26(19), 4698-4671.

YL Zhang, YJ Zhang, WM Wang, KW Yang*, "Synthesis and inhibitory activity of acetamidephosphonic acids against metallo-β-lactamases", Phosphorus, Sulfur, and Silicon and the Related Elements, 2017, 192(1), 14-18.

LL Zhou, YQ Zhou, YL Tang, KW Yang, L Zhang, LX Gao, GF Zhang, ZW Gao, WQ Zhang, "Antibacterial Fischer Carbenoid CO-Releasing Molecules (Fc-CORMs)", Chin. J. Org. Chem. 2016, 36, 2695-2703.

XL Liu, Y Shi, JS Kang, P Oelschlaeger, KW Yang*, "Amino acid thioester derivatives: a highly promising scaffold for the development of metallo-β-lactamase L1 inhibitors", ACS Med. Chem. Lett. 2015, 6(6), 660–664.

SK Yang, JS Kang, P Oelschlaeger, KW Yang*, "Azolylthioacetamide: a highly promising scaffold for the development of metallo-β-lactamase inhibitors", ACS Med. Chem. Lett. 2015, 6(4), 455-460.

YL Zhang, KW Yang*, YJ Zhou, AE LaCuran, P Oelschlaeger, MW Crowder, "Diaryl-substituted azolylthioacetamides: inhibitor discovery of New Delhi metallo-β-lactamase-1 (NDM-1)", Chem Med Chem. 2014, 9(11), 2445-2448.

CC Liu, LS Zhou, JY Liu, JM Xiao, HZ Gao, KW Yang*, "Photoinactivation of vancomycin-resistant Enterococci and Bacillus subtilis by novel conjugate norvancomycin-rhodamine B", New J. Chem. 2013, 37, 575-580.

L Feng, KW Yang*, SK Yang, M Aitha, AE LaCuran, P Oelschlaeger, MW Crowder*, "New β-phospholactam as acarbapenem transition state analog: synthesis of broad-spectrum inhibitor of metallo-β-lactamases", Bioorg. Med. Chem. Lett. 2013, 23, 5855–5859.

LS Zhou, KW Yang*, L Feng, JM Xiao, CC Liu, YL Zhang, MW Crowder*, "Novel fluorescent risedronates: synthesis, photodynamic inactivation and imaging of Bacillus subtilis", Bioorg. Med. Chem. Lett. 2013, 23, 949-954.

YL Zhang, JM Xiao, JL Feng, KW Yang*, L Feng, LS Zhou, MW Crowder*, "A novel fluorogenic substrate for dinuclear Zn(II)-containing metallo-β-lactamases", Bioorg. Med. Chem. Lett. 2013, 23, 1676-1679.

X Yang, YJ Zhou, P He, YH Guo, CJ Liu, and KW Yang*, "Activation free energy of Zn(II), Co(II) binding to metallo-β-lactamase ImiS", Chi. Chem. Lett. 2014, 25, 1323–1326.

Y Shi, L Feng, Q Yang, YJ Zhou, KW Yang*, "Thermokinetic evaluation of pyrrolidinedicarboxylic acid inhibiting cefalexin hydrolysis with metallo-β-lactamase L1 from Stenotrophomonas maltophilia", Thermochimica Acta, 2013, 563, 46-50.

L Zhai, LS Zhou, CC Liu, Y Shi, YJ Zhou, KW Yang*, "Determination of thermodynamic parameters of benzylpenicillin hydrolysis by metallo-β-lactamase CcrA from Bacteroides fragilis", Thermochimica Acta, 2013, 556, 54-57.

CC Liu, XB Zhao, KW Yang*, KZ Xu, L Zhai, X Yang, HZ Gao, "Exploring antibiotic resistance based on enzyme hydrolysis by microcalorimetry IV: determination of thermokinetic parameters of d-ala-d-ala hydrolysis with dipeptidase VanX", J. Therm. Anal. Calorim. 2013, 111(3), 1663-1667.

L Zhai, KW Yang*, CC Liu, KZ Xu, X Yang, HZ Gao, Y Shi, L Feng, C Jia, LS Zhou, JM Xiao, "Exploring antibiotic resistance based on enzyme hydrolsis by microcalorimetryⅢ: determination of thermokinetic parameters of cefazolin hydrolysis with metallo-β-lactamase CcrA", J. Therm. Anal. Calorim. 2013, 111(3), 1657-1661.

CC Liu, L Zhai, Y Shi, KW Yang*, "Purification of metallo-β-lactamase CcrA from Bacteroides fragilis with salting-out method", Braz. Arch. Biol. Technol. 2013, 56(5), 811-816.

L Feng, KW Yang*, LS Zhou, JM Xiao, X Yang, L Zhai, YL Zhang, MW Crowder*, "N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria", Bioorg. Med. Chem. Lett. 2012, 22, 5185–5189.

C Jia, KW Yang*, CC Liu, L Feng, JM Xiao, LS Zhou, YL Zhang, "Synthesis,characterization and activity of new phosphonate dipeptides as potential inhibitors of VanX", Bioorg. Med. Chem. Lett. 2012, 22, 482-484.

L Zhai, KW Yang*, CC Liu, HZ Gao, X Yang, Y Shi, J Wen, "Thermokinetic characterization of imipenem hydrolysis with metallo-β-lactamase CcrA from Bacteroides fragilis", Thermochimica Acta. 2012, 539, 67-70.

X Yang, L Feng, KZ Xu, HZ Gao, C Jia, CC Liu, JM Xiao, L Zhai, LS Zhou, KW Yang*, "Exploring antibiotic resistant mechanism by microcalorimetry II:determination of thermokinetic parameters of imipenem hydrolysis with metallo-β-lactamase ImiS", J. Therm. Anal. Calorim. 2012, 110, 945-948.

HZ Gao, Q Yang, XY Yan, ZJ Wang, JL Feng, X Yang, SL Gao, L Feng, X Cheng, C Jia, KW Yang*, "Determination of thermodynamic carameters of penicillin Ghydrolysis catalyzed by metallo-β-lactamase L1 from Stenotrophomonas maltophilia", J. Therm. Anal. Calorim. 2012, 107, 321-324.

KW Yang*, X Cheng, C Zhao, CC Liu, C Jia, L Feng, JM Xiao, LS Zhou, HZ Gao, X Yang, L Zhai, "Synthesis and activity study of phosphonamidate dipeptides as potential inhibitors of VanX", Bioorg. Med. Chem. Lett. 2011, 21, 7224-7227.

HZ Gao, KW Yang*, "Antibiotic resistance in superbugs: research progress of the metallo-β-lactamases", Chin. Pharm. J. 2011, 47(5), 325-330.

XB Zhao, ZH Zhang, XX Yan, KW Yang*, "Research process and application of bisphosphonate drugs", Chin. J. Osteoporos, 2011, 17(10), 65-69.

Yan XY, Gao HZ, Feng JL, Yang X, Feng L, Cheng X, Jia C, Yang KW*, "Wild-type and Co(II)substituted metallo-β-lactamase L1: spectroscopic characterization and kinetic studies of catalyzing antibiotic hydrolysis", Chin. J. Antibiot. 2011, 36(5), 388-393.

Feng JL, Yang X, Yan XY, Gao HZ, Feng L, Cheng X, Jia C, Wu D, Yang KW*, "Expression,purification of ImiS and kinetic studies on hydrolysis of three type of β-lactam antibiotics catalyzed by ImiS", Chin. J. Antibiot. 2011, 36(3), 197-200.

A.L. Costello, G. Periyannan, K.W. Yang, M.W. Crowder*, D.L. Tierney, "Site selective binding of Zn(II)to metallo-β-lactamase L1 from Stenotrophomonas maltophilia", J. Biol. Inorg. Chem. 2006, 11(3), 351-358.

A.L. Costello, N.P. Sharma, K.W. Yang, M.W. Crowder*, D.L. Tierney, "X-ray absorption spectroscopy of the zinc-binding sites in the class B2 metallo-β-lactamase ImiS from Aeromonas veronii bv. sobria", Biochemistry, 2006, 45, 13650-13658.

G.R. Periyannan, A.L. Costello, D.L. Tierney, K.W. Yang, B. Bennett, M.W. Crowder*, "Sequential binding of cobalt(II)to metallo-β-lactamase CcrA", Biochemistry, 2006, 45, 1313-1320.

N.P. Sharma, C. Hajdin, S. Chandrasekar, B. Bennett, K.W. Yang, M.W. Crowder*, "Mechanistic studies on the mononuclear Zn(II)-containing metallo-β-lactamase ImiS from Aeromonas sobria", Biochemistry, 2006, 45, 10729-10738.

P.A. Crawford, K.W. Yang, N. Sharma, B. Bennett, M.W. Crowder*, "Spectroscopic studies on Co(II)-substituted metallo-β-lactamase ImiS from Aeromonas veronii bv.sobria", Biochemistry, 2005, 44, 5168-5176.

K.W. Yang, F.C. Golich, T.K. Sigdel, M.W.Crowder*, "Phosphinate,sulfonate and sulfonamidate dipeptides as potential inhibitors of aminopeptidase N", Bioorg. Med. Chem. Lett. 2005, 15, 5150-5153.

G.P. Marasinghe, I.M. Sander, B. Bennett, G. Periyannan, K.W. Yang, C.A. Makaroff, M.W. Crowder*, "Structural studies on amitochondrial glyoxalase II", J. Biol. Chem. 2005, 280, 40668-40675.

K.W. Yang and M.W. Crowder*, "A method for removing ethylenediaminetetraacetic acid from apo-proteins", Anal. Biochem. 2004, 329, 342-344.

K.W. Yang, D.N. Sobieski, A.L. Carenbauer, P.A. Crawford, C.A. Makaroff, M.W. Crowder*, "Explaining the inhibition of glyoxalase II by 9-fluorenylmethoxycarbonyl-protected glutathione derivatives", Arch. Biochem. Biophys. 2003, 414, 271-278.

M.W. Crowder*, K.W. Yang, A.L. Carenbauer, G. Periyannan, M.E. Seifert, N.E. Rude, T.R. Walsh, "The problem of asolvent exposable disulfide when preparing Co(II)-substituted metallo-β-lactamase L1 from Stenotrophomonas maltophilia", J. Biol. Inorg. Chem. 2001, 6, 91-99.

K.W. Yang, J.J. Brandt, L.L. Chatwood, M.W. Crowder*, "Phosphonamidate and phosphothioate dipeptides as potential inhibitors of VanX", Bioorg. Med. Chem. Lett. 2000, 10, 1085-1087.

K.W. Yang, M.W. Crowder*, "Inhibition studies on the metallo-β-lactamase L1 rom Stenotrophomonas maltophilia", Arch. Biochem. Biophys. 1999, 368, 1-6.

J.J. Brandt, L.L. Chatwood, K.W. Yang, M.W. Crowder*, "Continuous assay for VanX,the D-ala-D-ala dipeptidase required for high-level vancomycin resistance", Anal. Biochem. 1999, 272, 94-99.

M.W. Crowder*, S. McMannus-Munoz, A.L. Carenbauer, M.Seifert, K.W. Yang, "Structure/function studies on metal-β-lactamase L1 from S.maltophilia. J. Inorg. Biochem. 1999, 74, 106.

K.W. Yang, Y.Z. Wang, Z.X. Huang*, J.Sun, "Active site model of carbonic anhydrase:synthesis and crystal structure of functional tetrahedral zinc complex with hydrotris(3-phenyl-5-methylpyrazol-1-yl)borate", Polyhedron, 1997, 16, 109-112.

K.W. Yang, Y.Z. Wang, Z.X. Huang*, J.Sun, "Synthesis,characterization and x-ray crystal structure of Zn(II)complex with poly-nitrogen ligand[(3-HB(3,5-Me2pz)3]2Zn2C6H5CH3", Polyhedron, 1997, 16, 1297-1300.

Yang K.W., Yin Y.Q., Wang Y.Z., Huang Z.X.*, "Studies on synthesis,characterization and quantum chemistry of carbonic anhydrase active site model compounds[(3-HB(3-Phpz)3ZnX](X=Cl,Br,Iand NO3)", “Acta Chimia Sinica, 1997, 55, 209-214.

K.W. Yang, Y.Q. Yin, Z.X. Huang*, Y.H. Wang, "Synthesis and crystal structure of zinc complex[Zn(P(py)3)2][Zn(NCS)4(MeCN)]", Polyhedron, 1996, 15, 79-81.

K.W. Yang, Y.Q. Yin*, D.S. Jin, "An active site model for carbonic anhydrase-synthesis and crystal structure of[(3-HB(3-Phpz)3]ZnBr", Polyhedron, 1995, 14, 1021-1023.

K.W. Yang, Y.Q. Yin*, D.S. Jin, "Preparation of copper(I)complexes with novel pyrazolyl borates", Chi. Chem. Lett. 1994, 5, 341-342.

Yang K.W., Wu J.G., Wang L.F.*, Yang Z.Y., "Determination of stability constants of rare earth(III)complexes by hypersensitive transition method", J. Lanzhou Uni.(Nat.Sci), 1994, 30, 49-52.

Yang Z.Y., Wang L.F.*, Wu J.G., Yang K.W., Zhu Y., "Studies on synthesis,characterization and electrical conductivity of complexes of 3d transition metal with 2-oxo-propionic acid(4-pyridinecarbonyl)hydrazone", Acta Chimia Sinica, 1993, 51, 184-190.

Yang K.W., Wu J.G., Wang L.F.*, Dong F., "Determination of stability constants of Nd(III)complexes with pantothenate by absorption spectroscopy", Chi. J. Inorg. Chem. 1993, 9, 271-274.

Wang L.F.*, Yang K.W., Wu J.G., "Determination of thermodynamical functions of neodymium pyridoxol complexes by hypersensitive transition method", Chi. J. Appl. Chem. 1993, 10, 84-86.

Yang Z.Y., Ai J., Wang L.F.*, Wu J.G., Yang K.W., "Studies on the synthesis characterization and antitumor activity of the temary complexes of rare earth(III)with schiff base", J. Lanzhou Uni.(Nat.Sci.), 1993, 29, 162-166.

Yang Z.Y., Wang L.F.*, Wu J.G., Li X.Y., Yang K.W., Wang Q., "Studies on anticancer activity of some rare earth(III) complexes with schif base", Chi. Sci. Bull. 1992, 9, 813-816.

K.W. Yang, L.F. Wang*, J.G. Wu, F. Dong, "Synthesis, characterization and antioxidative activity of new vitamin B6 triethanolamine rare earth(III) complexes", J. Inorg. Biochem. 1993, 52, 145-150.

K.W. Yang, L.F. Wang*, J.G. Wu, Z.Y. Yang, X. Gao, "Synthesis, characterization and antioxidative activity of vitamin B6 rare earth(III) complexes", J. Inorg. Biochem. 1993, 52, 151-155.